Abstract: The present disclosure describes various improvements for programmable nuclease-based detection assays. Also provided are compositions, methods, kits, systems, and devices for practicing the same. Such improvements include improved reporter designs to facilitate the cleavage of a reporter immobilized on a substrate by an activated programmable nuclease. Improved reporter designs may comprise various lengths and structures of the reporter. The substrate can also comprise immobilized guide nucleic acids and/or programmable nucleases.

Abstract: Systems, apparatuses, methods, and computer program products are disclosed for establishing shared trust between a client user and an agent user for a current communication. An example method includes providing a logon request for a client user account associated with a client user to a system device. The example method further includes generating a candidate authentication sequence code message using the mobile application in an instance in which the logon request was successfully authenticated and providing the candidate authentication sequence code message to a system device. The example method further includes receiving a shared trust decision message from the system device, wherein the shared trust decision message is indicative of the current communication verification status.

Abstract: Systems, apparatuses, methods, and computer program products are disclosed for establishing shared trust between a client user and an agent user for a current communication. An example method includes providing a logon request for a client user account associated with a client user to a system device. The example method further includes determining an authentication sequence code using the mobile application in an instance in which the logon request was successfully authenticated and causing the authentication sequence code to be provided to the agent device associated with the agent user. The example method further includes receiving a shared trust decision message from the system device, wherein the shared trust decision message is indicative of a verification status for the current communication.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for securely verifying an identity of a user of a client device based on a signal transmitted by the client device. For example, systems disclosed herein include registering a client device and facility device via a cloud computing system to enable the client device and facility device to securely communicate a signal via a wireless connection. The systems disclosed herein additionally include determining whether a trigger condition applies based on a position of the client device relative to the facility device. The systems disclosed herein further include maintaining and updating a subset of user verification information to include personal verification of a registered user of the client device. Using the subset of user verification information, a biometric scanning device may efficiently and accurately verify an identity of an individual associated with the client device.

Abstract: Improvements in image quality can be obtained by leveraging non-linear neural-network based feature recovery across multiple imaging modalities. Input imaging data is acquired, including first imaging data and second imaging data acquired using different imaging modalities. The first imaging data can have lower image quality and a larger FOV than the second imaging data. The first and second imaging data can be aligned and the aligned regions can be used to train a neural network to minimize the difference between the second imaging data and output data processed from the overlapping portion of the first imaging data. Once trained, the neural network can be used to generate improved image quality output from all of the first imaging data.

Abstract: A spray wand for use with a chemical or chemical formulation in solid form. The wand hose end has a wand hose end valve for control of water flow from a hose. A refill cartridge having a swirl chamber may be attached to the hollow tube. The refill cartridge has at least one nub, indent and/or external channel or groove on its external surface.

Abstract: A cutting head body for an agricultural machine, such as a mower or a trimmer, is configured to receive a cutting line for cutting weeds, grass, or other materials. The cutting head body includes an inlet area having a cavity with a node location configured to receive a node of a cutting line, and an outlet area having a cavity configured to open to an exterior of the cutting head body. The cutting head body may include a first passageway connecting the inlet area to the outlet area and a second passageway connecting the inlet area to the outlet area. The cutting head body is rotatable about a rotational axis to move the cutting line. In some embodiments, the cutting head body is fixed to a rotatable shaft. In some embodiments, the cutting head body rotates about a fixed shaft.

Abstract: A device may receive a first user interaction signal in response to a first user interaction with a first user interaction element. In response to the first user interaction signal, the device may provide a first instruction to the computing system to perform a first action with respect to the first indicator, wherein the first indicator is active. The device may receive a switch control signal in response to a second user interaction with a switch control element. The device may set the first indicator as the inactive indicator and the second indicator as the active indicator. The device may receive a second user interaction signal in response to a third user interaction with the first user interaction element and use the second controller to provide a second instruction to the computing system to perform a second action with respect to the second indicator.

Abstract: An interpolated flat-panel display comprises a display substrate and an array of clusters disposed on the display substrate. Each cluster comprises an exclusive group of display pixels and a cluster controller for controlling the display pixels. The cluster controller is operable to receive input data specifying a desired light output from one or more but fewer than all of the display pixels in the group of display pixels, calculate interpolated data at least in part from the input data, and drive the display pixels to emit light in response to the calculated interpolated data and received input data. The input data can correspond to an image pixel in an input image. The cluster controller can be operable to receive a parameter value describing attributes of a local portion of the input image including the image pixel and the interpolated data is calculated at least in part from the parameter value.

Abstract: An interpolated flat-panel display comprises a display substrate, pixel controllers disposed in a controller array over the display substrate, and pixels disposed in a pixel array over the display substrate. Each pixel controller is connected to one or more control lines and is operable to output pixel information. Each pixel is operable to emit light in response to pixel information received from a pixel controller. The pixel array is larger than the controller array, each pixel is connected to at least one pixel controller, and at least some pixels are interpolated pixels connected to at least two pixel controllers and are operable to emit light in response to pixel information received from the at least two pixel controllers.

Abstract: Improved (e.g., high-throughput, low-noise, and/or low-artifact) X-ray Microscopy images are achieved using a deep neural network trained via an accessible workflow. The workflow involves selection of a desired improvement factor (x), which is used to automatically partition supplied data into two or more subsets for neural network training. The neural network is trained by generating reconstructed volumes for each of the subsets. The neural network can be trained to take projection images or reconstructed volumes as input and output improved projection images or improved reconstructed volumes as output, respectively. Once trained, the neural network can be applied to the training data and/or subsequent data—optionally collected at a higher throughput—to ultimately achieve improved de-noising and/or other artifact reduction in the reconstructed volume.

Abstract: Apparatus includes a sample holder with a cavity and a plurality of devices configured to hold a curvature of a curved substrate in a fixed configuration. Apparatus includes two prisms with a viewing apparatus of the sample holder configured to translate therebetween. Methods can include disposing the curved substrate in the sample holder, transmitting a first beam, translating the sample holder, and transmitting a second beam. Alternatively, apparatus include a light scattering-polarimetry sub-system configured to emit a first beam to impinge an end surface of coupling prism and detect at least a portion of the first beam impinging the first surface of the coupling prism. The apparatus includes an evanescent prism coupling spectroscopy sub-system configured to emit a second beam to impinge a first surface of the coupling system and detect at least a portion of the second beam impinging the second surface of the coupling prism.

Abstract: A sheet of material that is marked with a pulsed laser, the sheet of material having an outer edge and an inner edge separated by a core. The distance from the outer edge to the inner edge is the sheet thickness. The sheet of material has a total concentration of TiO2 of less than about 1.00%. There is an exterior layer beginning at the outer edge and extending into the core, the thickness of the exterior layer is from about 10.00% to about 40.00% of the sheet thickness, and the exterior layer has an average concentration of from about 2.50% to about 10.00% TiO2.

Abstract: An exemplary wafer structure comprises a source wafer having a patterned sacrificial layer defining anchor portions separating sacrificial portions. A patterned device layer is disposed on or over the patterned sacrificial layer, forming a device anchor on each of the anchor portions. One or more devices are disposed in the patterned device layer, each device disposed entirely over a corresponding one of the one or more sacrificial portions and spatially separated from the one or more device anchors. A tether structure connects each device to a device anchor. The tether structure comprises a tether device portion disposed on or over the device, a tether anchor portion disposed on or over the device anchor, and a tether connecting the tether device portion to the tether anchor portion. The tether is disposed at least partly in the patterned device layer between the device and the device anchor.

Abstract: A method of enhancing a resolution of an EDS image of a sample includes generating an EDS image of the sample, generating a non-EDS image of the sample generating, using a machine learning algorithm, an enhanced resolution EDS image of the sample based on the generated feature map and based on the first EDS image, where a resolution of the enhanced resolution EDS image is higher than a resolution of the first EDS image.

Abstract: Provided are compounds of the Formula (IVB): or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.

Abstract: Data processing/GUIs for NFT block chain data to “tell the story” of ownership or highlight “cool” aspects of a computer game-related NFT in simplified way. Machine learning (ML) may be used to boil down the complexity of data to what people need or want to understand. The displayed timeline of ownership as presented in a GUI can be interactive. Types of metadata to encapsulate in the NFT are discussed.

Abstract: A surgical draping system includes an under-draping, an over-draping, and a connecting draping connected by the under-draping and the over-draping. The surgical draping system is used to establish and maintain a surgical corridor to a surgical site or sites on a patient supported by a surgical table. The surgical draping system can accommodate rotation of the patient on the surgical table, such that the sterile surgical corridor is maintained even during such rotation. The sterile surgical corridor extends through an aperture formed in the over-draping, through an enclosed passageway formed through the connecting draping, and through an aperture formed in the under-draping.