Patents by Inventor Matthew Angel

Matthew Angel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20200056207
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: October 16, 2019
    Publication date: February 20, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR NUCLEIC ACID PRODUCTION AND DELIVERY
    Publication number: 20200046807
    Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: September 6, 2019
    Publication date: February 13, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR TRANSFECTION
    Publication number: 20200048616
    Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
    Type: Application
    Filed: September 6, 2019
    Publication date: February 13, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • Cationic lipids and transfection methods
    Patent number: 10556855
    Abstract: The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: February 11, 2020
    Assignee: Factor Bioscience Inc.
    Inventors: Matthew Angel, Franklin Kostas, Christopher Rohde
  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20200040363
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: October 17, 2019
    Publication date: February 6, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20200040365
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: October 18, 2019
    Publication date: February 6, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20200040364
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: October 18, 2019
    Publication date: February 6, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20200032299
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: October 18, 2019
    Publication date: January 30, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20200032298
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: October 17, 2019
    Publication date: January 30, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20200032296
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: October 16, 2019
    Publication date: January 30, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20200032297
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: October 17, 2019
    Publication date: January 30, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20200032295
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: October 16, 2019
    Publication date: January 30, 2020
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR TRANSFECTING CELLS
    Publication number: 20190390174
    Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
    Type: Application
    Filed: September 11, 2019
    Publication date: December 26, 2019
    Inventors: Matthew ANGEL, Christopher ROHDE
  • Cationic lipids and transfection methods
    Patent number: 10501404
    Abstract: The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: December 10, 2019
    Assignee: Factor Bioscience Inc.
    Inventors: Matthew Angel, Franklin Kostas, Christopher Rohde
  • NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF
    Publication number: 20190365923
    Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
    Type: Application
    Filed: June 14, 2019
    Publication date: December 5, 2019
    Inventors: Matthew ANGEL, Christopher ROHDE
  • METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
    Publication number: 20190345519
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Application
    Filed: July 26, 2019
    Publication date: November 14, 2019
    Inventors: Matthew Angel, Christopher Rohde
  • Methods and products for transfecting cells
    Patent number: 10472611
    Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: November 12, 2019
    Assignee: Factor Bioscience Inc.
    Inventors: Matthew Angel, Christopher Rohde
  • Methods and products for transfection
    Patent number: 10443045
    Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: October 15, 2019
    Assignee: Factor Bioscience Inc.
    Inventors: Matthew Angel, Christopher Rohde
  • NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF
    Publication number: 20190307897
    Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
    Type: Application
    Filed: June 14, 2019
    Publication date: October 10, 2019
    Inventors: Matthew ANGEL, Christopher ROHDE
  • Methods and products for expressing proteins in cells
    Patent number: 10415060
    Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: September 17, 2019
    Assignee: Factor Bioscience Inc.
    Inventors: Matthew Angel, Christopher Rohde