Abstract: The present technology relates to compositions and methods for modulating expression of genes which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.

Abstract: An engine lubricating oil exhibiting a fuel economy improvement is disclosed. The engine oil composition meets at least one of ILSAC GF-4, API CI-4, API CJ4, ACEA A1, ACEA A5, ACEA B1, ACEA B5, ACEA C1, ACEA C2, ACEA C3, ACEA C4A, and JASO DL-1 performance specifications. The composition comprises at least an isomerized base oil comprising a consecutive number of carbon atoms and having a CCS Viscosity at ?35° C. of less than or equal to 7000 mPa, a T95-T5 boiling range distribution of less than or equal to 200° C., a ratio of weight percent molecules with monocycloparaffinic functionality to weight percent molecules with multicycloparaffinic functionality of greater than 15, and an Oxidator BN of greater than 30 hours; and 0.05 to 40 wt %. of at least an additive selected from the group of metal detergents, dispersants, wear inhibitors, anti-oxidants, friction modifiers, viscosity modifiers, corrosion inhibitors, seal swelling agents, metal deactivators, anti-foamants, and mixtures thereof.

Abstract: A multi-grade engine oil composition meeting required specifications of manufacturers is provided. In one embodiment, the engine oil composition contains a sufficient amount of a Pour Point Reducing Blend Component for the engine oil to have cold crank simulator viscosity at ?20° C. of less than have a cold crank simulator viscosity at ?20° C. of less than 9000 cP and a mini rotary viscometer (MRV) viscosity at ?20° C. of less than 60,000 cP. The Pour Point Reducing Blend Component is selected from 1) an isomerized Fischer-Tropsch derived bottoms product; 2) a bottoms product prepared from an isomerized highly waxy mineral oil, or 3) an isomerized oil having a kinematic viscosity at 100° C. of at least about 8 mm2/s made from polyethylene plastic.