Abstract: An authentication system may receive a request signature corresponding to a user request to view secure user information on a user device and generate a server-side signature matching the request signature to authenticate the user device to receive the secure user information without authenticating the user. The request signature may include a device identifier corresponding to the device, a token code generated by the authentication system and stored by the user device, a timestamp corresponding to the transmission time of the request signature, and a version of the device identifier, the token code, and the timestamp encrypted using a signature key provided to the user device by the authentication system. The authentication system may generate the server-side signature using the timestamp and stored copies of the device identifier, the token code, and the signature key.

Abstract: A substrate table for supporting a substrate includes a surface and coarse burls. Each of the coarse burls includes a burl-top surface and fine burls. The coarse burls are disposed on the surface of the substrate table. The fine burls are disposed on the burl-top surface. The fine burls contact the substrate when the substrate table supports the substrate.

Abstract: Described here are devices, systems, and methods for applying pulsed or modulated electric fields to tissue. In some variations, a device may comprise a first elongate body comprising a lumen, a second elongate body at least partially positioned within the lumen, and an expandable member rolled about the second elongate body. The expandable member may comprise an inner end coupled to the second elongate body, an outer end coupled to the first elongate body, and an electrode array.

Abstract: Systems and methods are disclosed herein for training machine learning models using precision data based on movement and timing of data collection. The system trains the machine learning model to predict object locations in an environment. The training data includes location data, timing data, and motion data, collection of which is triggered by a user input indicating that a particular object was located. The system generates precision parameters for the locations by assigning initial values to entries within the training data and may lower precision parameters based on the timing data indicating that an object was located faster than a threshold time or based on the motion data indicating that a rate of motion exceeded a threshold rate when a corresponding object was located. The system may update the training data with the lowered precision parameters and train the machine learning model to predict the object locations within the environment.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least section wise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A traffic sensor includes an imaging unit that generates a recognition record by image recognition processing a captured image of a vehicle. The recognition record includes personal-identification data useable to identify the vehicle owner, and additional data not useable to identify the vehicle owner. The traffic sensor also includes an obfuscation unit that generates an obfuscated record from the recognition record by converting the personal-identification data into a unique-identifier. The obfuscated record includes the unique-identifier and the additional data. The traffic sensor further includes a transceiver configured to transmit the obfuscated record to a first off-site server without transmitting the recognition record to the first off-site server.

Abstract: An enhanced routing system determines a service provider best suited to fulfill a user's request to interact and establishes a communication session between the user's client device and a device of the service provider. The enhanced routing system may use user characteristics and behavior to select the service provider. For example, the enhanced routing system receives a request to connect to a customer service system from a user who has recently started a new job and has been accessing a banking application on his mobile phone. The enhanced routing system may determine that a payroll service provider is best suited to fulfill the user's request. For example, the enhanced routing system uses a machine learning model that has been trained on previously fulfilled requests. In this way, the enhanced routing system improves upon systems that continuously prompt the user for information by selecting a service provider without overburdening the user.

Abstract: An intelligent item receptacle, system, and method for providing supplemental media content in response to depositing an item having media indicia disposed thereon. An intelligent item receptacle includes an item receptacle securely enclosing an interior volume, an item sensor configured to detect an inserted item, a camera within the interior volume configured to capture an image of the item, and an output configured to play audio or visual content to bystanders outside the item receptacle. Processing circuitry within the item receptacle analyzes the image to determine if the media indicia are present on the item and, if present, causes the output to play the audio or visual content associated with the media indicia.

Abstract: Oral care based imaging computer-implemented systems and methods for determining perceived attractiveness of a facial image portion of at least one person depicted in a digital image. The method has the following steps: a) obtaining a digital image comprising at least one oral feature of at least one person, wherein the digital image includes a facial image portion of the at least one person, the facial image portion having both positive and negative attributes as defined by pixel data of the digital image; b) analyzing the facial image portion; c) generating an Attractiveness Score indicative of a perceived attractiveness of the facial image portion based on the analyzed facial image portion in the obtained digital image; d) further generating an image description that identifies at least one area in said facial image portion based on the Attractiveness Score; and e) presenting the image description to a use.

Abstract: A package including an outer box and inner tray. The inner tray slidable into and out of the outer box. The outer box including a first tab, a second tab, and a lip. The first and second tabs movable toward an interior of the outer box when force is applied. The inner tray including a first flap and a second flap, the first and second flaps movable toward an interior of the inner tray when force is applied. When the inner tray is slid into the outer box and the first and second tabs are in a first position, the first and second flaps are engaged with the lip and the inner tray is locked to the outer box. When the first and second tabs are in a second position the first and second flaps are disengaged with the lip and the inner tray is slideable out of the outer box.

Abstract: Various embodiments are drawn to systems and methods for detecting an analyte of interest in a sample including an optical sensor, a capture probe attached to a surface of the optical sensor wherein the capture probe is capable of binding to the analyte to form a duplex or complex, and an antibody capable of binding to the analyte, duplex, or complex. In several embodiments, systems and methods further include a particle attached to the antibody or capable of binding to the antibody. In several embodiments, systems and methods for analyte detection feature one or more of the following: high detection sensitivity and specificity, scalability and multiplex capacity, ability to analyze large analytes, and ability to detect or measure multiple individual binding events in real-time.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: Transparently providing a virtualization feature to an unenlightened guest operating system (OS). A guest partition, corresponding to a virtual machine, is divided into a first guest privilege context and a second guest privilege context. A compatibility component executes within the first guest privilege context, while a guest OS executes within the second guest privilege context. The compatibility component is configured to intercept input/output (I/O) operations associated with the guest operating OS. Based on the compatibility component intercepting an I/O operation associated with the guest OS, the compatibility component processes the I/O operation using a virtualization feature that is unsupported by the guest OS. Examples of the virtualization feature include accelerated access to a hardware device and virtual machine guest confidentiality.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Non-combustible aerosol provision device 100 for generating an aerosol from an aerosol-generating material comprised in a consumable for being received by the device. The device comprises a chamber 102 for receiving the consumable, wherein the device is configured to generate the aerosol from the aerosol-generating material when the consumable is received in the chamber 102. The device 100 further comprises a consumable holder 500 for holding the consumable in the chamber 102, wherein the consumable holder 500 comprises at least two selectively engageable gripping members which are spaced from one another in an axial direction of the chamber 102 to grip different respective points on the consumable, such that the consumable holder is capable of holding, by use of the selectively engageable gripping members, one at a time, each of a plurality of differently-dimensioned consumables at a desired position in the chamber 102.

Abstract: A recoil device is provided for a gun having a barrel with a breech. The device includes a breech nut, a brake assembly, a pneumatic spring and a counter-recoil buffer. The breech nut has first and second adjacent sides. The brake assembly includes a brake cylinder that mounts to the breech nut on the first side. The pneumatic spring mounts to the breech nut on the second side. The counter-recoil buffer attaches to the pneumatic spring. The brake cylinder and the pneumatic spring internally push fluids for recoil absorption and return in response to firing the gun.

Abstract: A non-combustible aerosol provision device for generating an aerosol from an aerosol-generating material is disclosed. The non-combustible aerosol provision device includes a chamber for receiving a consumable including aerosol-generating material to enable the non-combustible aerosol provision device to generate an aerosol from the aerosol-generating material, wherein the chamber is configured to accommodate, one at a time, a first consumable comprising aerosol-generating material at a first axial position in the chamber and a second consumable including aerosol-generating material having different dimensions to those of the first consumable at a second axial position in the chamber.

Abstract: A composition, workout/exercise supplement, treatment method for conditions associated with vasoconstriction, and method of extracting galloylated procyanidins. The composition includes galloylated procyanidins having a preponderance of (?)-epicatechins. The treatment methods include administering a therapeutically effective amount of galloylated procyanidins having a preponderance of (?)-epicatechins. The extraction methods include isolating galloylated procyanidins having a preponderance of (?)-epicatechins from a sample that contains polyphenols, catechins, epicatechins, and galloylated epicatechins.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.