Patents by Inventor Matthew B. Wheeler
Matthew B. Wheeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11774454Abstract: The present disclosure provides non-invasive methods for determining the gender of an embryo during in vitro embryo culture.Type: GrantFiled: May 12, 2023Date of Patent: October 3, 2023Assignee: The Board of Trustees of the University of IllinoisInventors: Marcello Rubessa, Matthew B. Wheeler, Andrea Ambrosi, Scott E. Denmark, Dianelys Gonzalez-Pena
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Publication number: 20210055303Abstract: The present disclosure provides non-invasive methods for determining the gender of an embryo during in vitro embryo culture.Type: ApplicationFiled: August 24, 2020Publication date: February 25, 2021Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Marcello RUBESSA, Matthew B. WHEELER, Andrea AMBROSI, Scott E. DENMARK, Dianelys GONZALEZ-PENA
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Patent number: 9157550Abstract: Microfluidic systems and methods. A microfluidic device for in vitro fertilization comprises a substrate and a plurality of microchannels disposed in the substrate, including an inlet of at least two of the plurality of microchannels arranged on the substrate to align with a fluid-handling device. Another microfluidic system for assaying a plurality of cells comprises a substrate and a plurality of microfluidic channels comprising a source channel, a sink channel, and a cell chamber. An insert for a microfluidic system comprises a substrate configured to be inserted into a dish and a plurality of microscale wells disposed in the substrate. A microfluidic channel comprises a substrate and at least one microchannel having an open inlet, an open outlet, a channel, and an opening in the substrate disposed over a portion of the channel.Type: GrantFiled: January 5, 2010Date of Patent: October 13, 2015Assignee: The Board of Trustees of the University of IllinoisInventors: Matthew B. Wheeler, Dongshin Kim, David J. Beebe
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Publication number: 20100234674Abstract: Microfluidic systems and methods. A microfluidic device for in vitro fertilization comprises a substrate and a plurality of microchannels disposed in the substrate, including an inlet of at least two of the plurality of microchannels arranged on the substrate to align with a fluid-handling device. Another microfluidic system for assaying a plurality of cells comprises a substrate and a plurality of microfluidic channels comprising a source channel, a sink channel, and a cell chamber. An insert for a microfluidic system comprises a substrate configured to be inserted into a dish and a plurality of microscale wells disposed in the substrate. A microfluidic channel comprises a substrate and at least one microchannel having an open inlet, an open outlet, a channel, and an opening in the substrate disposed over a portion of the channel.Type: ApplicationFiled: January 5, 2010Publication date: September 16, 2010Inventors: Matthew B. Wheeler, Dongshin Kim, David J. Beebe
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Patent number: 7371922Abstract: Provided is a method for the production of transgenic animals, especially pigs, by the use of nuclear transfer from genetically modified or other embryonic stem cells to either enucleated oocytes which were matured in vivo or in vitro and activated or to enucleated zygotes.Type: GrantFiled: July 31, 2003Date of Patent: May 13, 2008Assignee: The Board of Trustees of the University of IllinoisInventors: Matthew B. Wheeler, Brett R. White
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Patent number: 7169963Abstract: The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase activity. The present invention thus provides a method of facilitating piglet development and decreasing piglet mortality.Type: GrantFiled: September 30, 2003Date of Patent: January 30, 2007Assignee: Board of Trustees of the University of IllinoisInventors: Matthew B. Wheeler, Sharon M. Donovan, Gregory T. Bleck, Marcia Monaco-Siegel
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Patent number: 7071373Abstract: Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric ungulates confirmed by genetic markers which have germ cells comprising the exogenous genetic material. The chimeric ungulates are bred to provide transgenic ungulates. The transgenic animals of the invention may show improved qualities and can be used to provide human proteins or peptide hormones or can be used as xenograft donors.Type: GrantFiled: March 24, 1995Date of Patent: July 4, 2006Assignee: The Board of Trustees of the University of IllinoisInventor: Matthew B. Wheeler
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Publication number: 20040107454Abstract: Provided is a method for the production of transgenic animals, especially pigs, by the use of nuclear transfer from genetically modified or other embryonic stem cells to either enucleated oocytes which were matured in vivo or in vitro and activated or to enucleated zygotes.Type: ApplicationFiled: July 31, 2003Publication date: June 3, 2004Inventors: Matthew B. Wheeler, Brett R. White
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Publication number: 20040064841Abstract: The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase activity. The present invention thus provides a method of facilitating piglet development and decreasing piglet mortality.Type: ApplicationFiled: September 30, 2003Publication date: April 1, 2004Applicant: Board of Trustees of the University of IllinoisInventors: Matthew B. Wheeler, Sharon M. Donovan, Gregory T. Bleck, Marcia Monaco-Seigel
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Patent number: 6695765Abstract: Microfluidic embryo scaled channels for handling and positioning embryos provide the opportunity to evaluate and treat embryos in improved manners Fluid flow is used to move and position embryos within microfluidic channels and channel geometries may be used to place embryos at specific locations. Surface properties and compliance (deformation) properties of embryos are evaluated as a predictor of viability. The microfluidic channels provide the opportunity for fine controls of pressure to conduct various evaluations at forces slightly below which damage to embryos is known to occur.Type: GrantFiled: May 12, 2000Date of Patent: February 24, 2004Assignee: The Board of Trustees of the University of IllinoisInventors: David J. Beebe, Ian K. Glasgow, Matthew B. Wheeler, Henry Zeringue
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Patent number: 6677500Abstract: The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase activity. The present invention thus provides a method of facilitating piglet development and decreasing piglet mortality.Type: GrantFiled: August 15, 2001Date of Patent: January 13, 2004Assignee: Board of Trustees of the University of IllinoisInventors: Matthew B. Wheeler, Sharon M. Donovan, Gregory T. Bleck, Marcia Monaco-Seigel
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Publication number: 20020144296Abstract: The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also relates to methods for increasing piglet weight gain and intestinal lactase activity. The present invention thus provides a method of facilitating piglet development and decreasing piglet mortality.Type: ApplicationFiled: August 15, 2001Publication date: October 3, 2002Inventors: Matthew B. Wheeler, Sharon M. Donovan, Gregory T. Bleck, Marcia Monaco-Seigel
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Patent number: 6193647Abstract: A microfluidic embryo handling device and method in which biological rotating of embryos is simulated. Fluid flow is used to move and position embryos without assistance of electrical stimulus or other means which may produce undesired heating of biological medium used as the fluid for transporting and position. Continuous or pulsed flow is maintained around an embryo or embryos in the device. The device provides an excellent simulation of biological conditions and may be used for culturing, sorting, testing, evaluating, fertilizing and other similar typical handling operations. An embryo may be parked at a desired location to carry out such a typical operation, while the microfluidic handling device maintains fluid flow around the embryo.Type: GrantFiled: April 8, 1999Date of Patent: February 27, 2001Assignee: The Board of Trustees of the University of IllinoisInventors: David J. Beebe, Ian K. Glasgow, Matthew B. Wheeler
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Patent number: 5942435Abstract: Transgenic swine, and compositions and methods for making and using same, are provided. Central to the invention are porcine (Sus scrofa) embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric swine, which have germ cells comprising the exogenous genetic material. The chimeric swine are bred to provide transgenic swine. Transgenic swine of the invention can be used to provide human proteins or peptide hormones or can be used as xenograft donors.Type: GrantFiled: June 6, 1995Date of Patent: August 24, 1999Assignees: The Board of Trustees of the University of Illinois, Biotechnology Research and Development Corp.Inventor: Matthew B. Wheeler
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Patent number: 5523226Abstract: Transgenic swine, and compositions and methods for making and using same, are provided. Central to the invention are porcine (Sus scrofa) embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric swine, which have germ cells comprising the exogenous genetic material. The chimeric swine are bred to provide transgenic swine. Transgenic swine of the invention can be used to provide human proteins or peptide hormones or can be used as xenograft donors.Type: GrantFiled: May 14, 1993Date of Patent: June 4, 1996Assignees: Biotechnology Research and Development Corp., Board of Trustees of the University of IllinoisInventor: Matthew B. Wheeler