Patents by Inventor Matthew Beaver

Matthew Beaver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of KRAS G12C inhibitor compound
    Patent number: 12466825
    Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2,2?,2?-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-fluorophenol), useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: November 11, 2025
    Assignee: AMGEN INC.
    Inventors: Andrew T. Parsons, Matthew Beaver
  • Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof
    Patent number: 11708341
    Abstract: The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure Compound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: July 25, 2023
    Inventors: Matthew Beaver, Sheng Cui, Xiangqing Shi
  • IMPROVED SYNTHESIS OF KRAS G12C INHIBITOR COMPOUND
    Publication number: 20230192681
    Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2,2?,2?-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-fluorophenol), useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
    Type: Application
    Filed: November 13, 2020
    Publication date: June 22, 2023
    Inventors: Andrew T. PARSONS, Matthew BEAVER
  • Synthesis of (S)-2-Amino-4-Methyl-((R)-2-Methyloxirane-2-Yl)-Pentan-1-One and Pharmaceutically Acceptable Salts Thereof
    Publication number: 20210284617
    Abstract: The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure Compound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.
    Type: Application
    Filed: August 3, 2017
    Publication date: September 16, 2021
    Inventors: Matthew BEAVER, Sheng CUI, Xiangqing SHI
  • Paper Dunnage Apparatus
    Publication number: 20170100906
    Abstract: An apparatus for forming paper dunnage from rolled paper web includes a frame, a paper trough connected to the frame for supporting and retaining a paper roll, and a crumpling mechanism connected to the frame for drawing and receiving the paper web from the paper roll and crumpling the paper web to form paper dunnage. A paper guide is connected to the frame for receiving and guiding the paper web intermediate the paper trough and the crumpling mechanism. The paper guide is spring biased to maintain the paper web in tension between the paper roll and the crumpling mechanism. The paper guide can be a spring biased, pivotally mounted guide bar. Alternatively, the paper guide can be a cantilevered sheet of springy material having a free end that engages the paper web.
    Type: Application
    Filed: October 13, 2015
    Publication date: April 13, 2017
    Applicant: LINCOLN CODERS CORP.
    Inventors: Matthew Beaver, Luis DeVeyra, Robert Beaver