Abstract: Systems, methods, and devices for a graphical user interface (GUI) builder for a heads-up display. A user may interface with the GUI builder to create a profile. The profile comprises a logical ordering of one or more screens, with each screen comprising at least one widget. The widgets may be configured to display data on the screen and may be configurable by the user. Profiles may be shared with other users. A software development kit may be provided for developing custom widgets. The heads-up display may be on a night vision device.

Abstract: The invention relates to RNA molecules encoding an E. coli fimbrial H antigen (FimH). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the prevention of E. coli infection, including urinary tract infection.

Abstract: A spheroid cell culture article including: a chamber including: an opaque side wall surface; a top aperture; and a gas-permeable, liquid impermeable bottom including at least one concave surface, wherein at least a portion of the bottom is transparent, wherein at least a portion of the bottom includes a low-adhesion or no-adhesion material in or on the at least one concave surface, and wherein the gas permeable, liquid impermeable bottom includes polystyrene.

Abstract: Provided herein are anti-CD21 antibodies or antigen binding fragments thereof and their use in the treatment of autoimmune diseases or disorders.

Abstract: Systems, methods, and devices for a graphical user interface (GUI) builder for a heads-up display. A user may interface with the GUI builder to create a profile. The profile comprises a logical ordering of one or more screens, with each screen comprising at least one widget. The widgets may be configured to display data on the screen and may be configurable by the user. Profiles may be shared with other users. A software development kit may be provided for developing custom widgets. The heads-up display may be on a night vision device.

Abstract: The present invention provides for CD80-Fc fusion proteins that have therapeutic and diagnostic use, and methods for making thereof. The present invention further relates to variant CD80 polypeptides. The present invention also provides for CD80-Fc fusion proteins for use in the treatment of cancer.

Abstract: Systems, methods, and devices for a graphical user interface (GUI) builder for a heads-up display. A user may interface with the GUI builder to create a profile. The profile comprises a logical ordering of one or more screens, with each screen comprising at least one widget. The widgets may be configured to display data on the screen and may be configurable by the user. Profiles may be shared with other users. A software development kit may be provided for developing custom widgets. The heads-up display may be on a night vision device.

Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: A training simulator provides an immersive virtual training environment depicting an operator performing healthcare tasks to a patient. The simulator includes a head-mounted display unit (HMDU). The HMDU includes a camera, a speaker, a display, and a sensor providing visual and audio output to the operator. The simulator also includes one or more controllers, each having a sensor. The controller sensors and the HMDU sensor output signals representing spatial positioning, angular orientation and movement data of the controllers relative to the patient. The simulator includes a data processing system that models and renders the patient including a condition of the patient, the operator, used healthcare equipment and supplies, changes to the condition of the patient and the used healthcare equipment and supplies, and sensory guidance as to the operator's performance of the healthcare tasks to simulate the virtual training environment and to evaluate the operator's performance.

Abstract: A visibility measurement device (10) comprising a camera (12) and a computing device (14) communicatively coupled to the camera and configured to: receive a first image from the camera; select a measurement feature in the first image, the measurement feature corresponding to a location within the field of view of the camera; measure an optical characteristic of the measurement feature to obtain a measured optical characteristic value for the location; and determine an ambient fog intensity value based on: the measured optical characteristic value; a reference optical characteristic value for the location; and a distance between the camera and the location, such that the ambient fog intensity value can be used to calculate the visibility in a direction between the camera and the location.

Abstract: A method and system for providing synchronized input feedback, comprising receiving an input event, encoding the input event in an output stream wherein the encoding of the input event is synchronized to a specific event and reproducing the output stream through an output device whereby the encoded input event in the reproduced output stream is imperceptible to the user

Abstract: A video game inventory coach AI model may suggest video game inventory items to discard, obtain, and/or use based on a user's gameplay style and clusters of other players. The inventory coach model may be turned on and off at a target player's discretion.

Abstract: A cell culture system for culturing cells is provided. The cell culture system including a cell culture vessel with a cell culture chamber for culturing cells, an inlet through which liquid can flow for filling the cell culture vessel, and an outlet through which fluid can exit the cell culture vessel. The system also includes at least one fill sensor arranged to detect liquid within the cell culture vessel reaching a fill level at a predetermined position of the cell culture vessel during filling of the cell culture vessel, where the at least one fill sensor can generate a detection signal when liquid within the cell culture vessel reaches the fill level. Also included is an actuator to change an orientation of the cell culture vessel in response to the detection signal.

Abstract: The present disclosure relates to RNA molecules encoding a varicella zoster virus (VZV). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the treatment or prevention of herpes zoster or shingles.

Abstract: A method and system for providing synchronized input feedback, comprising receiving an input event, encoding the input event in an output stream wherein the encoding of the input event is synchronized to a specific event and reproducing the output stream through an output device whereby the encoded input event in the reproduced output stream is imperceptible to the user.

Abstract: A video game inventory coach AI model may suggest video game inventory items to discard, obtain, and/or use based on a user's gameplay style and clusters of other players. The inventory coach model may be turned on and off at a target player's discretion.

Abstract: A real-time virtual reality welding system including a programmable processor-based subsystem, a spatial tracker operatively connected to the programmable processor-based subsystem, at least one mock welding tool capable of being spatially tracked by the spatial tracker, and at least one display device operatively connected to the programmable processor-based subsystem. The system is capable of simulating, in virtual reality space, a weld puddle having real-time molten metal fluidity and heat dissipation characteristics. The system is further capable of importing data into the virtual reality welding system and analyzing the data to characterize a student welder's progress and to provide training.

Abstract: The present disclosure provides processes for refining hydrocarbon feedstocks and apparatus thereof. In at least one embodiment, a process includes hydroprocessing a mineral hydrocarbon feedstock in the presence of a first catalyst in a first reactor, and removing a first reactor effluent from the first reactor. The process includes hydroprocessing a biocomponent feedstock in the presence of a second catalyst in a second reactor, and removing a second reactor effluent from the second reactor. The process includes mixing the first reactor effluent and the second reactor effluent to form a mixture. The process includes introducing the mixture to a separation unit to form a fuel product. In at least one embodiment, an apparatus includes a first hydroprocess reactor. The apparatus includes a second hydroprocess reactor coupled with the first hydroprocess reactor. The apparatus includes a separation unit coupled with the second hydroprocess reactor.

Abstract: A spheroid cell culture article including: a frame having a chamber including: an opaque side wall surface; a top aperture; a gas-permeable, transparent bottom; and optionally a chamber annex surface and second bottom, and at least a portion of the transparent bottom includes at least one concave arcuate surface, is disclosed. Methods of making and using the article are also disclosed.

Abstract: A real-time virtual reality welding system including a programmable processor-based subsystem, a spatial tracker operatively connected to the programmable processor-based subsystem, at least one mock welding tool capable of being spatially tracked by the spatial tracker, and at least one display device operatively connected to the programmable processor-based subsystem. The system is capable of simulating, in virtual reality space, a weld puddle having real-time molten metal fluidity and heat dissipation characteristics. The system is further capable of importing data into the virtual reality welding system and analyzing the data to characterize a student welder's progress and to provide training.