Abstract: The present disclosure relates to aerosol delivery devices, methods of forming such devices, and elements of such devices. In some embodiments, the present disclosure provides a heating member that can be formed of a heating element conformed to a heater substrate configured as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size. In some embodiments, the disclosure provides methods of forming an aerosol delivery device, which can include providing a shell, providing a heating member formed of a heating element conformed to a substrate, configuring the heating member as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size, and inserting the heating member within the shell.

Abstract: Synthetic ?v?6 integrin ligands of Formula I having serum stability and affinity for integrin ?v?6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin ?v?6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include ?v?6 integrin ligands and methods of use are also described.

Abstract: The present disclosure relates to aerosol delivery devices, methods of forming such devices, and elements of such devices. In some embodiments, the present disclosure provides a heating member that can be formed of a heating element conformed to a heater substrate configured as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size. In some embodiments, the disclosure provides methods of forming an aerosol delivery device, which can include providing a shell, providing a heating member formed of a heating element conformed to a substrate, configuring the heating member as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size, and inserting the heating member within the shell.

Abstract: Ovens, discharge nozzle plates for distribution of gas through an oven, and methods to operate an oven are disclosed. Example ovens include a heating system to heat gas, a substrate heating volume, and a plenum comprising a side wall having a plurality of passages formed therein, the plenum configured to direct heated gas into the substrate heating volume from the plurality of passages, each of the plurality of passages formed in the plenum having a respective tapered cross-sectional shape.

Abstract: A deployable working surface is provided for use in a reconfigurable passenger cabin of a personal automotive vehicle. The vehicle includes a first seat that can rotate to an inwardly-rotated position. The working surface is provided by a panel that is mounted on a second seat for movement between a stowed position and a working position. This movement includes vertical movement and rotational movement about a vertical axis. When the panel is in the working position, the working surface extends in a radial direction that is perpendicular to the direction the first seat is facing when in the rotated position and is positioned higher that an occupant seating surface of the first seat and in front of a backrest of the first seat.

Abstract: A vehicle seat with a seat bottom and backrest is configured for movement between a forward-facing position and an inwardly-rotated position in a reconfigurable vehicle passenger cabin. The movement includes rotation about a vertical axis located along an inboard side of the seat and a rear side of the seat bottom. The vertical axis can be located within an inboard quarter of the seat, rearward of an occupant seating surface of the seat bottom, forward or rearward of a rear side of a bottom end of the backrest, and various combinations of these locations. In addition to providing a seat occupant with additional freedom of movement within the passenger cabin, the inwardly-rotated position of the seat can also provide a safer condition for the seat occupant with respect to structural portions of the vehicle body.

Abstract: One embodiment is directed to an oven for heating fibers. The oven comprises a supply structure disposed within the oven between first and second ends of the oven. The supply structure comprises a plurality of plenums stacked one above each other with gaps therebetween. The plenums are in fluid communication with a heating system. At least one plenum comprises at least one side wall comprising a plurality of passages formed therein, said at least one plenum configured to direct at least a portion of the heated gas into an interior of the oven from the plurality of passages. Each of the plurality of passages formed in said at least one plenum has a respective tapered cross-sectional shape.

Abstract: A personal automotive vehicle includes a door with a door panel that partly defines a reconfigurable passenger cabin. The door panel presents an abrasion-resistant portion to the interior of the passenger cabin at an upper section of the door panel below the window. A seat is mounted in the passenger cabin and can be rotated inwardly to increase the available range of movement of the seat occupant. The abrasion-resistant portion of the door panel is located to prevent scuff-related damage to the door panel when the seat occupant crosses his legs. The abrasion-resistant portion of the door panel can be selectively covered and uncovered by a moveable portion of the door panel, which may include an armrest.

Abstract: A foot rest for use in a reconfigurable passenger cabin of a personal automotive vehicle is moveable between a first position and a second position. In the second position, a resting surface of the foot rest is inclined to face toward a seat when the seat is moved away from a forward-facing position to a rotated position. In the first position, the resting surface can be level with a floor of the passer cabin, facing toward a different seat, or facing toward the same seat as in the second position. The foot rest provides stability to a seat occupant when the seat is moved into unconventional positions, such as rotated or extreme rearward positions.

Abstract: One embodiment is directed to an oven for heating fibers. The oven comprises a supply structure disposed within the oven between first and second ends of the oven. The supply structure comprises a plurality of plenums. The plenums are in fluid communication with a heating system. Each of the plenums comprises a pair of side walls, a bottom wall, and a top wall. Each of the plenums is configured so that first openings are formed in the respective side walls of that plenum. At least one plenum is configured so that one or more second openings are formed in at least one of the top wall or the bottom wall of at least one plenum. The at least one plenum is configured to supply heated gas from the heating system into the chamber from the first openings and said one or more second openings of the plenum.

Abstract: A vehicle seat with a seat bottom and backrest is configured for movement between a forward-facing position and an inwardly-rotated position in a reconfigurable vehicle passenger cabin. The movement includes rotation about a vertical axis located along an inboard side of the seat and a rear side of the seat bottom. The vertical axis can be located within an inboard quarter of the seat, rearward of an occupant seating surface of the seat bottom, forward or rearward of a rear side of a bottom end of the backrest, and various combinations of these locations. In addition to providing a seat occupant with additional freedom of movement within the passenger cabin, the inwardly-rotated position of the seat can also provide a safer condition for the seat occupant with respect to structural portions of the vehicle body.

Abstract: A deployable working surface is provided for use in a reconfigurable passenger cabin of a personal automotive vehicle. The vehicle includes a first seat that can rotate to an inwardly-rotated position. The working surface is provided by a panel that is mounted on a second seat for movement between a stowed position and a working position. This movement includes vertical movement and rotational movement about a vertical axis. When the panel is in the working position, the working surface extends in a radial direction that is perpendicular to the direction the first seat is facing when in the rotated position and is positioned higher that an occupant seating surface of the first seat and in front of a backrest of the first seat.

Abstract: A foot rest for use in a reconfigurable passenger cabin of a personal automotive vehicle is moveable between a first position and a second position. In the second position, a resting surface of the foot rest is inclined to face toward a seat when the seat is moved away from a forward-facing position to a rotated position. In the first position, the resting surface can be level with a floor of the passer cabin, facing toward a different seat, or facing toward the same seat as in the second position. The foot rest provides stability to a seat occupant when the seat is moved into unconventional positions, such as rotated or extreme rearward positions.

Abstract: A personal automotive vehicle includes a door with a door panel that partly defines a reconfigurable passenger cabin. The door panel presents an abrasion-resistant portion to the interior of the passenger cabin at an upper section of the door panel below the window. A seat is mounted in the passenger cabin and can be rotated inwardly to increase the available range of movement of the seat occupant. The abrasion-resistant portion of the door panel is located to prevent scuff-related damage to the door panel when the seat occupant crosses his legs. The abrasion-resistant portion of the door panel can be selectively covered and uncovered by a moveable portion of the door panel, which may include an armrest.

Abstract: Ovens, discharge nozzle plates for distribution of gas through an oven, and methods to operate an oven are disclosed. Example ovens include a heating system to heat gas, a substrate heating volume, and a plenum comprising a side wall having a plurality of passages formed therein, the plenum configured to direct heated gas into the substrate heating volume from the plurality of passages, each of the plurality of passages formed in the plenum having a respective tapered cross-sectional shape.

Abstract: One embodiment is directed to an oven for heating fibers. The oven comprises a supply structure disposed within the oven between first and second ends of the oven. The supply structure comprises a plurality of plenums stacked one above each other with gaps therebetween. The plenums are in fluid communication with a heating system. At least one plenum comprises at least one side wall comprising a plurality of passages formed therein, said at least one plenum configured to direct at least a portion of the heated gas into an interior of the oven from the plurality of passages. Each of the plurality of passages formed in said at least one plenum has a respective tapered cross-sectional shape.

Abstract: One embodiment is directed to an oven for heating fibers. The oven comprises a supply structure disposed within the oven between first and second ends of the oven. The supply structure comprises a plurality of plenums. The plenums are in fluid communication with a heating system. Each of the plenums comprises a pair of side walls, a bottom wall, and a top wall. Each of the plenums is configured so that first openings are formed in the respective side walls of that plenum. At least one plenum is configured so that one or more second openings are formed in at least one of the top wall or the bottom wall of at least one plenum. The at least one plenum is configured to supply heated gas from the heating system into the chamber from the first openings and said one or more second openings of the plenum.

Abstract: Approaches for acquiring CT image data corresponding to a full scan, but at a reduced dose are disclosed. In one implementation, X-ray tube current modulation is employed to reduce the effective dose. In other implementations, acquisition of sparse views, z-collimation, and two-rotation acquisition protocols may be employed to achieve a reduced dose relative to a full-scan acquisition protocol.

Abstract: Approaches are described for addressing artifacts associated with iterative reconstruction of image data acquired using a cone-beam CT system. Such approaches include, but are not limited to, the use of asymmetric regularization during iterative reconstruction, the modulation of regularization strength for certain voxels, the modification of statistical weights, and/or the generation and use of synthesized data.

Abstract: The present disclosure relates to iterative reconstruction of images. In certain embodiments, a deconvolution filter is used to approximate the inversion of a Hessian matrix associated with the reconstruction. In one such embodiment, the desired image is not reconstructed directly in the iterative process. Instead, an image is reconstructed that yields the desired image when filtered by the deconvolution filter.