Patents by Inventor Matthew Bernasconi
Matthew Bernasconi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250011716Abstract: Knit scaffolds for culturing cells and aiding in the healing of functional tissue are provided. The knit scaffolds have properties aligned with specific tissues for providing optimal tissue growing surfaces including matched biomechanical properties. The scaffolds are made up of knitted material and do not require or utilize a support skeleton for function. Methods of making and using the knit scaffolds are also provided.Type: ApplicationFiled: December 21, 2023Publication date: January 9, 2025Applicant: Massachusetts Institute of TechnologyInventors: Steven R. Gillmer, Ming Guo, Erin Doran, Emily Holtzman, Ariel Sandberg, Matthew Bernasconi
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Publication number: 20240165868Abstract: Methods of manufacturing multi-material fibers having one or more electrically-connectable devices disposed therein are described. In certain instances, the methods include the steps of: positioning the electrically-connectable device(s) within a corresponding pocket provided in a preform material; positioning a first electrical conductor longitudinally within a first conduit provided in the preform material; and drawing the multi-material fiber by causing the preform material to flow, such that the first electrical conductor extends within the multi-material fiber along a longitudinal axis thereof and makes an electrical contact with a first electrode located on each electrically-connectable device. A metallurgical bond may be formed between the first electrical conductor and the first electrode while drawing the multi-material fiber and/or, after drawing the multi-material fiber, the first electrical conductor may be located substantially along a neutral axis of the multi-material fiber.Type: ApplicationFiled: January 29, 2024Publication date: May 23, 2024Inventors: Chia-Chun Chung, Jason Cox, Kristina McCarthy, Kristen Mulherin, Jimmy Nguyen, Michael Rein, Matthew Bernasconi, Lauren Cantley, Lalitha Parameswaran, Michael Rickley, Alexander Stolyarov, Joshua Deisenhaus
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Patent number: 11951672Abstract: Methods of manufacturing multi-material fibers having one or more electrically-connectable devices disposed therein are described. In certain instances, the methods include the steps of: positioning the electrically-connectable device(s) within a corresponding pocket provided in a preform material; positioning a first electrical conductor longitudinally within a first conduit provided in the preform material; and drawing the multi-material fiber by causing the preform material to flow, such that the first electrical conductor extends within the multi-material fiber along a longitudinal axis thereof and makes an electrical contact with a first electrode located on each electrically-connectable device. A metallurgical bond may be formed between the first electrical conductor and the first electrode while drawing the multi-material fiber and/or, after drawing the multi-material fiber, the first electrical conductor may be located substantially along a neutral axis of the multi-material fiber.Type: GrantFiled: April 21, 2021Date of Patent: April 9, 2024Assignees: Advanced Functional Fabrics of America, Inc., Massachusetts Institute of TechnologyInventors: Chia-Chun Chung, Jason Cox, Kristina McCarthy, Kristen Mulherin, Jimmy Nguyen, Michael Rein, Matthew Bernasconi, Lauren Cantley, Lalitha Parameswaran, Michael Rickley, Alexander Stolyarov
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Publication number: 20240052528Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawirg the multifilament, yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.Type: ApplicationFiled: October 20, 2023Publication date: February 15, 2024Applicant: Tepha, Inc.Inventors: Amit Ganatra, Fabio Felix, Bhavin Shah, Matthew Bernasconi, Said Rizk, David P. Martin, Simon F. Williams
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Patent number: 11828006Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.Type: GrantFiled: March 9, 2020Date of Patent: November 28, 2023Assignee: Tepha, Inc.Inventors: Amit Ganatra, Fabio Felix, Bhavin Shah, Matthew Bernasconi, Said Rizk, David P. Martin, Simon F. Williams
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Publication number: 20220096716Abstract: Methods to produce laminates including layers of constructs made from P4HB and copolymers thereof have been developed. These laminates may be used as medical implants, or further processed to make medical implants. The laminates are produced at a temperature equal to or greater than the softening points of the P4HB or copolymers thereof. The layers may include oriented forms of the constructs. Orientation can be preserved during lamination so that the laminate is also oriented, when the laminates are formed at temperatures less than the de-orientation temperatures of the layers. The laminate layers may include, for example, films, textiles, including woven, knitted, braided and non-woven textiles, foams, thermoforms, and fibers. The laminates preferably include one or more oriented P4HB films.Type: ApplicationFiled: September 22, 2021Publication date: March 31, 2022Applicant: Tepha, Inc.Inventors: Said Rizk, David P. Martin, Fabio Felix, Matthew Bernasconi, Bhavin Shah, Simon F. Williams
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Publication number: 20210362396Abstract: Methods of manufacturing multi-material fibers having one or more electrically-connectable devices disposed therein are described. In certain instances, the methods include the steps of: positioning the electrically-connectable device(s) within a corresponding pocket provided in a preform material; positioning a first electrical conductor longitudinally within a first conduit provided in the preform material; and drawing the multi-material fiber by causing the preform material to flow, such that the first electrical conductor extends within the multi-material fiber along a longitudinal axis thereof and makes an electrical contact with a first electrode located on each electrically-connectable device. A metallurgical bond may be formed between the first electrical conductor and the first electrode while drawing the multi-material fiber and/or, after drawing the multi-material fiber, the first electrical conductor may be located substantially along a neutral axis of the multi-material fiber.Type: ApplicationFiled: April 21, 2021Publication date: November 25, 2021Inventors: Chia-Chun Chung, Jason Cox, Joshua Deisenhaus, Kristina McCarthy, Kristen Mulherin, Jimmy Nguyen, Michael Rein, Matthew Bernasconi, Lauren Cantley, Lalitha Parameswaran, Michael Rickley, Alexander Stolyarov
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Patent number: 11154642Abstract: Methods to produce laminates including layers of constructs made from P4HB and copolymers thereof have been developed. These laminates may be used as medical implants, or further processed to make medical implants. The laminates are produced at a temperature equal to or greater than the softening points of the P4HB or copolymers thereof. The layers may include oriented forms of the constructs. Orientation can be preserved during lamination so that the laminate is also oriented, when the laminates are formed at temperatures less than the de-orientation temperatures of the layers. The laminate layers may include, for example, films, textiles, including woven, knitted, braided and non-woven textiles, foams, thermoforms, and fibers. The laminates preferably include one or more oriented P4HB films.Type: GrantFiled: December 18, 2014Date of Patent: October 26, 2021Assignee: Tepha, Inc.Inventors: Said Rizk, David P. Martin, Fabio Felix, Matthew Bernasconi, Bhavin Shah, Simon F. Williams
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Publication number: 20200240044Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.Type: ApplicationFiled: March 9, 2020Publication date: July 30, 2020Inventors: Amit Ganatra, Fabio Felix, Bhavin Shah, Matthew Bernasconi, Said Rizk, David P. Martin, Simon F. Williams
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Patent number: 10590566Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.Type: GrantFiled: March 19, 2018Date of Patent: March 17, 2020Assignee: Tepha, Inc.Inventors: Amit Ganatra, Fabio Felix, Bhavin Shah, Matthew Bernasconi, Said Rizk, David P. Martin, Simon F. Williams
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Patent number: 10227713Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.Type: GrantFiled: December 5, 2016Date of Patent: March 12, 2019Assignee: Tepha, Inc.Inventors: Amit Ganatra, Fabio Felix, Bhavin Shah, Matthew Bernasconi, Said Rizk, David P. Martin, Simon F. Williams
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Patent number: 10179189Abstract: Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.Type: GrantFiled: May 19, 2017Date of Patent: January 15, 2019Assignee: Tepha, Inc.Inventors: Matthew Bernasconi, Dennis Connelly, Said Rizk, David P. Martin, Simon F. Williams
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Publication number: 20180209073Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.Type: ApplicationFiled: March 19, 2018Publication date: July 26, 2018Inventors: Amit Ganatra, Fabio Felix, Bhavin Shah, Matthew Bernasconi, Said Rizk, David P. Martin, Simon F. Williams
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Publication number: 20170252481Abstract: Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.Type: ApplicationFiled: May 19, 2017Publication date: September 7, 2017Inventors: Matthew Bernasconi, Dennis Connelly, Said Rizk, David P. Martin, Simon F. Williams
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Patent number: 9687585Abstract: Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.Type: GrantFiled: August 20, 2014Date of Patent: June 27, 2017Assignee: Tepha, Inc.Inventors: Matthew Bernasconi, Dennis Connelly, Said Rizk, David P. Martin, Simon F. Williams
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Patent number: 9655609Abstract: Compositions and materials for making soft suture anchors comprising materials that improve osteointegration have been developed. These compositions and materials comprise bioceramics, resorbable materials, and combinations thereof. A preferred embodiment comprises a soft suture anchor comprising a resorbable ceramic and a resorbable suture.Type: GrantFiled: July 10, 2014Date of Patent: May 23, 2017Assignee: Tepha, Inc.Inventors: Said Rizk, David P. Martin, Matthew Bernasconi, Simon F. Williams
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Publication number: 20170081784Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.Type: ApplicationFiled: December 5, 2016Publication date: March 23, 2017Inventors: Amit Ganatra, Fabio Felix, Bhavin Shah, Matthew Bernasconi, Said Rizk, David P. Martin, Simon F. Williams
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Patent number: 9555155Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.Type: GrantFiled: December 10, 2015Date of Patent: January 31, 2017Assignee: Tepha, Inc.Inventors: Amit Ganatra, Fabio Felix, Bhavin Shah, Matthew Bernasconi, Said Rizk, David P. Martin, Simon F. Williams
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Publication number: 20160166727Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.Type: ApplicationFiled: December 10, 2015Publication date: June 16, 2016Inventors: Amit Ganatra, Fabio Felix, Bhavin Shah, Matthew Bernasconi, Said Rizk, David P. Martin, Simon F. Williams
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Patent number: 9149561Abstract: Compositions of P4HB and processes to injection mold these compositions have been developed. These compositions are prepared from P4HB polymers and blends having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g, moisture contents of less than 0.5% by weight, and more preferably less than 0.05% by weight, and using a polymer melt temperature during molding of at least 150° C. A preferred embodiment comprises a P4HB molding with an intrinsic viscosity of less than 3.2 dl/g that degrades rapidly in vivo.Type: GrantFiled: March 13, 2013Date of Patent: October 6, 2015Assignee: Tepha, Inc.Inventors: Said Rizk, Dennis W. Connelly, Matthew Bernasconi, Andrew J. Carter, David P. Martin, Simon F. Williams