Patents by Inventor Matthew Bottomley

Matthew Bottomley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified meningococcal fHbp polypeptides
    Patent number: 11939357
    Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHpb which can be modified to enhance their properties.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: March 26, 2024
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew Bottomley, Vega Masignani
  • Modified meningococcal fHbp polypeptides
    Patent number: 11932671
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: March 19, 2024
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew Bottomley, Enrico Malito, Manuele Martinelli, Maria Scarselli
  • MODIFIED CYTOMEGALOVIRUS PROTEINS AND STABILIZED COMPLEXES
    Publication number: 20230248820
    Abstract: Described are mutant, human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
    Type: Application
    Filed: April 18, 2018
    Publication date: August 10, 2023
    Inventors: Enrico Malito, Sumana Chandramouli, Andrea Carfi, Matthew Bottomley
  • MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES
    Publication number: 20220002355
    Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHpb which can be modified to enhance their properties.
    Type: Application
    Filed: June 14, 2021
    Publication date: January 6, 2022
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew BOTTOMLEY, Vega MASIGNANI
  • MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES
    Publication number: 20210253647
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 19, 2021
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew BOTTOMLEY, Enrico MALITO, Manuele MARTINELLI, Maria Scarselli
  • Modified meningococcal fHbp polypeptides
    Patent number: 11066450
    Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHbp which can be modified to enhance their properties.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: July 20, 2021
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew Bottomley, Vega Masignani
  • Modified meningococcal FHBP polypeptides
    Patent number: 11021522
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: June 1, 2021
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew Bottomley, Enrico Malito, Manuele Martinelli, Maria Scarselli
  • MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES
    Publication number: 20190315812
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Application
    Filed: July 1, 2019
    Publication date: October 17, 2019
    Inventors: Matthew BOTTOMLEY, Enrico MALITO, Manuele MARTINELLI
  • Modified meningococcal fHbp polypeptides
    Patent number: 10392424
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: August 27, 2019
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew Bottomley, Enrico Malito, Manuele Martinelli, Maria Scarselli
  • MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES
    Publication number: 20170226161
    Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHbp which can be modified to enhance their properties.
    Type: Application
    Filed: July 16, 2015
    Publication date: August 10, 2017
    Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
    Inventors: Matthew Bottomley, Vega Masignani
  • MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES
    Publication number: 20170008933
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Application
    Filed: February 27, 2015
    Publication date: January 12, 2017
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew BOTTOMLEY, Enrico MALITO, Manuele MARTINELLI, Maria SCARSELLI
  • STABILISED PROTEINS FOR IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS
    Publication number: 20150191513
    Abstract: Elimination of disulphide bond formation of cysteine-containing S. aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S. aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
    Type: Application
    Filed: August 29, 2013
    Publication date: July 9, 2015
    Inventors: Fabio Bagnoli, Matthew Bottomley, Guido Grandi, Mikkel Nissum, Michele Pallaoro, Silvana Savino