Abstract: The present invention provides a method of treating a disease or disorder caused by and/or associated with ABCD1 dysfunction in a human patient, the method comprising administering to the patient in need thereof an effective amount of a compound that increases the activity of triggering receptor expressed on myeloid cells 2 (TREM2). In some embodiments, compound that increases the activity of TREM2 is an agonist of TREM2. In some embodiments, the agonist of TREM2 is a small molecule agonist of TREM2 or an antibody agonist of TREM2.

Abstract: The present invention provides a method of treating a disease or disorder caused by and/or associated with CSF1R dysfunction in a human patient, the method comprising administering to the patient in need thereof an effective amount of a compound that increases the activity of triggering receptor expressed on myeloid cells 2 (TREM2). In some embodiments, compound that increases the activity of TREM2 is an agonist of TREM2. In some embodiments, the agonist of TREM2 is a small molecule agonist of TREM2 or an antibody agonist of TREM2.

Abstract: This invention relates to a cyclone for dense medium separation that includes an inverted conical shaped cyclone body which provides an interior space having an inner wall surface a vortex finder including a lower end that extends longitudinally into an upper region of the interior space of the cyclone body an overflow outlet associated with an upper end of the vortex finder a feed inlet that is in fluid communication with the upper region of the interior space of the cyclone body an outlet associated with a lower region of the interior space and the inner wall surface of the interior space curves inwardly and downwardly from the upper region curves inwardly and downwardly from the upper region of the interior space to the lower region of the interior space.

Abstract: This invention relates to a cyclone for dense medium separation that includes an inverted conical shaped cyclone body which provides an interior space having an inner wall surface a vortex finder including a lower end that extends longitudinally into an upper region of the interior space of the cyclone body an overflow outlet associated with an upper end of the vortex finder a feed inlet that is in fluid communication with the upper region of the interior space of the cyclone body an outlet associated with a lower region of the interior space and the inner wall surface of the interior space curves inwardly and downwardly from the upper region curves inwardly and downwardly from the upper region of the interior space to the lower region of the interior space.

Abstract: A payments gateway operable to receive a payments file from an originating entity. The payments gateway then invokes a policy associated with the originating entity, with the policy comprising references to at least a subset of a plurality of receiving entities. The payments file is parsed into a plurality of payment records, with each record associated with a particular one of the plurality of receiving entities. The payments gateway identifies a first receiving entity associated with one of the payment records and referenced in the policy and automatically provides a dashboard view to the identified receiving entity with the dashboard view presenting information on the one or more associated payment records.

Abstract: A printing device (2) for printing an image on an image receiving medium which includes a controller for generating a control signal defining the value of at least one parameter for controlling the device which has at least one characteristic in accordance with which a desired value of the parameter is selected. A keyboard matrix having a plurality of key connectors arranged in rows and columns with keys (6) arranged at intersections of the rows and columns is provided. The keys (6) can be actuated by a user to input to the controller data for controlling the printing device. Intersections each have an activated state when the associated key (6) is actuated and an inactive state when the associated key (6) is not actuated. An addiitional connector is provided which defines a set of intersections with said rows or said columns of key connectors so that at least one of said set of intersections is maintained in an activated state.