Abstract: A tooling apparatus for applying a tape material to a pre-formed insert is provided. The tooling apparatus comprises at least one guiding element coupled to an apparatus frame. An attachment shaft defines a rotational axis and extends through the guiding element. The attachment shaft includes an attachment element for securing the pre-formed insert thereto. An activation element is operatively engaged with the attachment shaft to rotate the pre-formed insert about the rotational axis at a predetermined rotation rate. A tape control assembly is spaced from the attachment shaft for axial translation along a tape control axis at a predetermined translation rate. Rotation of the pre-formed insert about the rotational axis and translation of the tape control element at the predetermined translation rate causes the material to be drawn under tension from the tape control assembly and applied to the pre-formed insert in a plurality of layers.

Abstract: A portable coffee press assembly, grinder and accessories. The portable coffee press assembly can be of a double-walled stainless steel design to improve insulative properties and facilitate manual handling during pressing. The portable grinder can be of a generally cylindrical design that fits into an open cavity of the piston of the press assembly. The grinder can include a removeable crank arm positionable in a storage configuration along the grinder body or in a grinding configuration extending laterally to facilitate manual grinding. The crank arm handle can be of generally circular shape to align along the top of the grinder and be magnetic to releasably secure to the grinder body. Portable accessories can further include a cup and lid with integrated filter storage, and a double-walled glass mug.

Abstract: Disclosed is a method of navigating an autonomous vehicle (AV) including recognizing a scene and commanding the AV based on a template configured for the scene. A system includes a processor configured for the method.

Abstract: A tooling apparatus for applying a tape material to a pre-formed insert is provided. The tooling apparatus comprises at least one guiding element coupled to an apparatus frame. An attachment shaft defines a rotational axis and extends through the guiding element. The attachment shaft includes an attachment element for securing the pre-formed insert thereto. An activation element is operatively engaged with the attachment shaft to rotate the pre-formed insert about the rotational axis at a predetermined rotation rate. A tape control assembly is spaced from the attachment shaft for axial translation along a tape control axis at a predetermined translation rate. Rotation of the pre-formed insert about the rotational axis and translation of the tape control element at the predetermined translation rate causes the material to be drawn under tension from the tape control assembly and applied to the pre-formed insert in a plurality of layers.

Abstract: A handrail return for a handrail is provided. The hollow body can include a first end, a second end, a rib, and a projection. The first end can include a first projection and a first aperture. The first projection can have a first height. The first aperture can be disposed through the first end and the exterior surface. The first aperture can permit for coupling between the hollow body and the handrail. The rib can be disposed along a portion of the interior surface. The projection can be disposed on the interior surface between the first protrusion and the second end. The projection can have a projection height being greater than the first height and configured to interact with the handrail to limit a depth of the handrail within the hollow body.

Abstract: An in vitro method of preparing a population of hypoimmune mammalian stem cells includes providing a population of isolated mammalian stem cells, wherein the isolated mammalian stem cells express a cell adhesion molecule; and modifying the expression of the cell adhesion molecule in the population of isolated mammalian stem cells to decrease or knockout expression of the cell adhesion molecule and provide the population of hypoimmune mammalian cells. The population of isolated mammalian stem cells can be pluripotent stem cells, or embryonic stem cells, and can be human or non-human stem cells.

Abstract: An inflatable wading boots including a boots assembly and an inflatable assembly. The boots assembly includes wading boots integrated to waders. The inflatable assembly includes a bladder, and a bulb. The bladder is an inflatable bladder. The bulb is an air pump. The bladder is connected to the pump. The bladder and the pump are mounted to each of the boots. The bladder is inflated to secure the boots to the feet of a user preventing the boots from getting off of the feet. The waders has bladders at a waist portion, a back portion and shoulder portion to inflate and prevent sinking.

Abstract: In an aspect, a method of making a humanized animal includes providing an immune-deficient animal lacking mature T cells, B cells and NK cells; and injecting a population of human thymocytes into the immune-deficient animal to provide the humanized animal; wherein the population of human thymocytes are thymocytes collected from human thymus or thymus tissue; and wherein the humanized animal includes mature human T cells expressing human CD8 and human CD4. In another aspect, also included is a humanized animal prepared by the foregoing method.