Abstract: Disclosed herein are methods and materials for treating cancer. The present disclosure further provides methods and materials for using one or more antigen binding proteins (for example anti-B-cell maturation antigen (BCMA) antigen binding proteins) and one or more cereblon E3 ligase modulators (CELMODs) for treating a subject having cancer.

Abstract: A method of operating a vehicle includes a vehicle controller receiving a key-on command to turn on the vehicle. A touchscreen display interface mounted to a central hub of a steering wheel assembly of the vehicle's steering system displays a wheel angle indicator at a first location and a soft touch controls set at a second location. A position sensor generates sensor data indicative of a steering angle of a front vehicle wheel and/or a position of a user's hand on a handwheel of the steering wheel assembly. The touchscreen display interface displays: the wheel angle indicator moved to a new orientation responsive to the sensor data indicating the front vehicle wheel's steering angle is a non-zero angle, and/or the soft touch controls set moved to a new location responsive to the sensor data indicating the user's hand position moved to a new position on the steering wheel assembly's handwheel.

Abstract: Disclosed herein are methods and materials for treating cancer. The disclosure further provides methods and materials for using one or more antigen binding proteins (for example anti-B-cell maturation antigen (BCMA) antigen binding proteins) and one or more T cell engagers for treating a subject having cancer.

Abstract: A method at a computing device, the method including obtaining, from a global work queue, a marker containing an identifier for an ordered job queue and determining whether the ordered job queue is blocked. The method further including selectively processing the marker based on whether the ordered job queue is blocked. When the ordered job queue is blocked, the selective processing the marker including placing the marker back on the global work queue; and obtaining from the global work queue another job. When the ordered job queue is not blocked, the selective processing the marker including blocking the ordered job queue; obtaining a job from the ordered job queue; processing the job; and upon completing the processing of the job, unblocking the ordered job queue.

Abstract: A suspension control system includes: an acceleration module configured to determine a predicted lateral acceleration of a vehicle in the future based on a radius of curvature of a road a predetermined distance in front of the vehicle; and at least one of: a damping module configured to, before the vehicle reaches the curvature, selectively adjust damping coefficients of adjustable dampers of the vehicle based on the predicted lateral acceleration; and an active roll control (ARC) control module configured to, before the vehicle reaches the curvature, selectively adjust stiffness of ARC devices of the vehicle based on the predicted lateral acceleration.

Abstract: A suspension control system includes: an acceleration module configured to determine a predicted lateral acceleration of a vehicle in the future based on a radius of curvature of a road a predetermined distance in front of the vehicle; and at least one of: a damping module configured to, before the vehicle reaches the curvature, selectively adjust damping coefficients of adjustable dampers of the vehicle based on the predicted lateral acceleration; and an active roll control (ARC) control module configured to, before the vehicle reaches the curvature, selectively adjust stiffness of ARC devices of the vehicle based on the predicted lateral acceleration.

Abstract: A method for determining a physical characteristic on a punctual location inside a medium, comprising the steps of: sending an emitted sequence comprising emitted pulses having different amplitudes, receiving a received sequence comprising received pulses corresponding to echoes of emitted pulses, calculating a phase difference between the received pulses relative to the emitted pulses, and determining the physical characteristic on the bases of a phase difference.

Abstract: A method for determining a physical characteristic on a punctual location inside a medium, comprising the steps of: sending an emitted sequence comprising emitted pulses having different amplitudes, receiving a received sequence comprising received pulses corresponding to echoes of said emitted pulses, calculating a phase difference between the received pulses relative to the emitted pulses, and determining the physical characteristic on the bases of said phase difference.

Abstract: The method of the invention determines a physical characteristic on a punctual location inside a medium, and includes including the steps of sending an emitted sequence having emitted pulses that have different amplitudes, receiving a received sequence having received pulses corresponding to echoes of the emitted pulses, calculating a phase difference between the received pulses relative to the emitted pulses, and determining the physical characteristic on the punctual location on the bases of said the phase difference.

Abstract: A method for determining a physical characteristic on a punctual location inside a medium, comprising the steps of: sending an emitted sequence comprising emitted pulses having different amplitudes, receiving a received sequence comprising received pulses corresponding to echoes of said emitted pulses, calculating a phase difference between the received pulses relative to the emitted pulses, and determining the physical characteristic on the bases of said phase difference.

Abstract: An ultrasound imaging system (10) is disclosed for creating simultaneous needle and vascular blood flow color Doppler imaging. A B mode image of an anatomical area of interest is created. A first set of Doppler image data optimized for the visualization of vascular blood flow is created along one Doppler image processing path. A second set of Doppler image data optimized for the visualization of a needle or other invasive device is created along another, parallel Doppler image processing path. A color Doppler image is created, and then displayed, by combining some or all of the B mode image, the first Doppler image data and the second Doppler image data based on a plurality of user selectable modes.

Abstract: A method and system of imaging is provided. The system can include an imaging system (10) having at least one probe (120) for transmitting imaging energy into a region (150) of a body (50) and receiving response energy; a display device (170); and a processor (100) operably coupled to the at least one probe and the display device. The processor can generate a first image based on the response energy. The processor can present the first image on the display device. The processor can present on the display device a second image of the same plane or volume as the first image. The first image is different from the second image. The processor can retrieve a designation of a region of interest from a clinician that is associated with one of the first and second images. The processor can compare the first image with the second image for graphical differences, and the processor can present the region of interest on the other of the second image based at least in part on the graphical differences.

Abstract: A method and a device for conducting perfusion studies on myocardial tissues with contrast agents is provided. In accordance with the method, ultrasound pulses are transmitted (111) into a patient, and ultrasound echoes of the pulses are received (113) which correspond to both myocardial tissue blood and chamber blood within said patient. The received ultrasound echoes are converted (115) into image data which corresponds to essentially only the myocardium perfusion.

Abstract: Significant liver growths such as HCC lesions are detected during a contrast agent ultrasound exam by their early reception of contrast and brightening following a bolus injection, as compared with surrounding normal tissue and benign growths. A pixel classifier looks for and identifies pixel or voxel regions where this early wash-in of contrast occurs and denotes these pixel or voxel locations in a parametric image. The pixel classifier analyzes pixel or voxel values from a sequence of images and identifies suspicious regions in an image by uniquely coding the points in a parametric liver image where early wash-in occurs.

Abstract: A method and device for imaging contrast agents which oscillate nonlinearly in a nondestructive mode at an MI in excess of 0.1 is described. Three transmit pulses are transmitted in each beam direction which are differently modulated. In an illustrated embodiment the transmit pulses are symmetrically differently phase modulated at 0°, 120° and 240°. The echoes received in response to each transmit pulse are stored and combined by a pulse inversion processor. Pulse inversion processing results in separation of the third harmonic to the relative exclusion of the first and second harmonic signal components. Third harmonic images of the contrast image are formed which exhibit a relatively low tissue background.

Abstract: An ultrasonic diagnostic imaging method and system produce diagnostic contrast images depicting both tissue perfusion and flow velocity in larger vessels by utilizing both linear and nonlinear imaging techniques. A sequence of echoes from differently modulated transmit pulses is received and processed in different ways to detect nonlinear signals from microbubble-perfused tissue and Doppler blood flow in larger vessels. The Doppler flow signals may be either linear or nonlinear or a mixture of both. A decision circuit classifies the detected signals for display pixels in a perfusion and/or flow and/or tissue image. Separate perfusion and flow images can be simultaneously displayed or an image of both perfusion and flow can be displayed.

Abstract: An ultrasonic imaging method and apparatus are described for imaging the coronary arteries of the heart. The vascular system is infused with an ultrasonic contrast agent. A volumetric region of the heart wall including a coronary artery is three dimensionally scanned. A projection image of the volumetric region is produced from the scanning, providing a two dimensional contrast image of the coronary artery with the appearance of an angiogram. Preferably the coronary artery signals are segmented from contrast signals emanating from the myocardium and the heart blood pool so that the coronary arteries are clearly highlighted and distinct in the ultrasonic angiogram.

Abstract: An ultrasonic diagnostic imaging system and method are presented to determine low rates of blood flow using contrast agents. Pairs of differently modulated pulses are transmitted in several beam directions to acquire echoes which can be combined to separate harmonic frequencies by pulse inversion. The pulses of each pair are transmitted in rapid succession to minimize motional artifacts. The transmission in the different beam directions is time-interleaved, resulting in the sampling of each beam direction over a long ensemble time for the detection of low rates of flow.

Abstract: Apparatus and methods are disclosed for the detection and imaging of ultrasonic contrast agents. Ultrasonic apparatus is provided for coherent imaging of ultrasonic contrast agents, and for detecting harmonic contrast agents. The inventive apparatus includes a dual display for simultaneously viewing a real time image which displays the location of the contrast agent and a triggered contrast image. Methods of contrast agent detection and imaging include the measurement of perfusion rate characteristics, multizone contrast imaging, multifrequency contrast imaging, tissue perfusion display, and high PRF contrast image artifact elimination.

Abstract: Apparatus and methods are disclosed for the detection and imaging of ultrasonic contrast agents. Ultrasonic apparatus is provided for coherent imaging of ultrasonic contrast agents, and for detecting harmonic contrast agents. The inventive apparatus includes a dual display for simultaneously viewing a real time image which displays the location of the contrast agent and a triggered contrast image. Methods of contrast agent detection and imaging include the measurement of perfusion rate characteristics, multizone contrast imaging, multifrequency contrast imaging, tissue perfusion display, and high PRF contrast image artifact elimination.