Patents by Inventor Matthew Buschman

Matthew Buschman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Innate Immunity Killer Cells Targeting PSMA Positive Tumor Cells
    Publication number: 20230096410
    Abstract: The present disclosure provides an innate immunity cell such as a gamma delta T (gdT) cell, Natural Killer (NK) cell, or macrophage having 2-[3-(1,3-dicarboxypropyl)ureido] pentanedioic acid (DUPA) chemically conjugated to the cell surface. The DUPA-conjugated cells provided herein demonstrate increased cytotoxicity toward cancer cells expressing PSMA. DUPA-conjugated cells can be primary cells or cells of a cell line. Also provided are methods of conjugating DUPA to the surface of NK cells, gamma delta T (gdT) cells, or macrophages and methods of treating cancer using DUPA-conjugated NK cells, gamma delta T (gdT) cells, or macrophages.
    Type: Application
    Filed: March 5, 2021
    Publication date: March 30, 2023
    Applicant: Sorrento Therapeutics, Inc.
    Inventors: Yanwen Fu, Reyna Lim, Daniel Lee, Matthew Buschman, Tong Zhu, Alisher B. Khasanov