Abstract: An electronic device, while displaying a representation of a piece of music, detects a first input event at a location corresponding to the representation of the piece of music, and in response, provides tactile feedback that corresponds to at least a subset of beats of the piece of music. Subsequently, in response to detecting a second input event at the location corresponding to the representation of the piece of music, the electronic device ceases to provide the tactile feedback that corresponds to the beats of the piece of music.

Abstract: Embodiments of the invention include systems, apparatus, and methods for detecting copy number variation (CNV) in the genomes of one or more patients. Samples of DNA may be taken from several patients, and then sections of the patients' DNA may be sequenced, e.g., through a process that may include, for each patient, one or more of: purifying, concentrating, fragmenting, labeling, filtering, and amplifying that patient's DNA. Fragments from several patients may be pooled, and the fragments in the pool may be sequenced. The sequencing data is then subjected to analysis, which includes several normalization steps. The normalized data are then examined to identify CNV, which is reported.

Abstract: Embodiments of the invention include systems, apparatus, and methods for detecting copy number variation (CNV) in the genomes of one or more patients. Samples of DNA may be taken from several patients, and then sections of the patients' DNA may be sequenced, e.g., through a process that may include, for each patient, one or more of: purifying, concentrating, fragmenting, labeling, filtering, and amplifying that patient's DNA. Fragments from several patients may be pooled, and the fragments in the pool may be sequenced. The sequencing data is then subjected to analysis, which includes several normalization steps. The normalized data are then examined to identify CNV, which is reported.

Abstract: Embodiments of the invention include systems, apparatus, and methods for detecting copy number variation (CNV) in the genomes of one or more patients. Samples of DNA may be taken from several patients, and then sections of the patients' DNA may be sequenced, e.g., through a process that may include, for each patient, one or more of: purifying, concentrating, fragmenting, labeling, filtering, and amplifying that patient's DNA. Fragments from several patients may be pooled, and the fragments in the pool may be sequenced. The sequencing data is then subjected to analysis, which includes several normalization steps. The normalized data are then examined to identify CNV, which is reported.

Abstract: A steam generator system for a pressurized water reactor which employs an external to containment steam drum and recirculation loop piping. The steam generator system changes the arrangement of a typical pressurized water reactor recirculation steam generator by relocating the functions of steam separation and feedwater preheating outside of the reactor coolant system. The steam generator system and thermal hydraulic conditions are selected in order to minimize the size of the steam generator heat exchanger component volume inside of the containment. The external steam drum component can be isolated in accident conditions when desired and is used as a source of secondary fluid inventory for improved decay heat removal capability and tolerance for loss of feedwater events. Thus, the steam generator component volume inside of the containment is reduced and the amount of maintenance required for the reactor coolant system components are similarly reduced.

Abstract: A steam generator system for a pressurized water reactor which employs an external to containment steam drum and recirculation loop piping. The steam generator system changes the arrangement of a typical pressurized water reactor recirculation steam generator by relocating the functions of steam separation and feedwater preheating outside of the reactor coolant system. The steam generator system and thermal hydraulic conditions are selected in order to minimize the size of the steam generator heat exchanger component volume inside of the containment. The external steam drum component can be isolated in accident conditions when desired and is used as a source of secondary fluid inventory for improved decay heat removal capability and tolerance for loss of feedwater events. Thus, the steam generator component volume inside of the containment is reduced and the amount of maintenance required for the reactor coolant system components are similarly reduced.

Abstract: A song audio is played and a graphical representation of a musical instrument contributing to the audio is displayed. A fingering display is overlayed on the graphical representation of the instrument during the playing of song. The fingering display is synchronized to the song audio. During the playing of the song audio, the tempo of the song is adjusted. The pitch of the song is substantially preserved in real-time despite the tempo adjustment. In addition, the synchronization between the fingering display and the audio are maintained in real-time in view of the adjusted tempo.