Abstract: Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with myocardial infarction (MI) and revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto one or more percutaneous transluminal vascular intervention (PTVI) devices during the revascularization procedure. In one embodiment, a PTVI device releases a conductive liquid to provide a conductive medium between a pacing electrode and tissue of pacing site.

Abstract: A delivery device and method for deploying a stent-graft within a body lumen of a patient are provided. According to one embodiment, the delivery device includes a tubular member lock that couples an outer tubular member of the device with an inner tubular member, such that as the outer tubular member is retracted to deploy the stent-graft, the distal-most end of the delivery device is also retracted. In one embodiment, the delivery device also includes a stent lock disposed on an intermediate tubular member that is configured to releasably couple the stent-graft and the intermediate tubular member. The inner tubular member and the outer tubular member are configured to be coupled to one another such that movement of the outer tubular member results in movement of the inner tubular member with respect to the intermediate tubular member so as to deploy the stent-graft.

Abstract: A medical device delivery system comprises an inner tube, a medical device disposed about a portion of the distal region of the inner tube, a medical device sheath disposed about the medical device, a medical device sheath retraction device extending proximally from the medical device sheath and an outer sheath disposed about a portion of the medical device sheath retraction device. The distal end of the outer sheath terminates at least one medical device length proximal of the medical device. The medical device sheath is movable relative to the outer sheath and relative to the inner tube.

Abstract: A medical device delivery system comprises an inner tube, a medical device disposed about a portion of the distal region of the inner tube, a medical device sheath disposed about the medical device, a medical device sheath retraction device extending proximally from the medical device sheath and an outer sheath disposed about a portion of the medical device sheath retraction device. The distal end of the outer sheath terminates at least one medical device length proximal of the medical device. The medical device sheath is movable relative to the outer sheath and relative to the inner tube.

Abstract: Embodiments of the present invention provide devices and methods for treating various target sites. For example, one exemplary device includes a tubular structure having proximal and distal ends and at least one layer of braided material configured to facilitate thrombosis. The tubular structure includes an end section at the proximal or distal end having a cross-sectional dimension that is larger than that of an opening of the target site. The device also includes a stiffener wire coupled to the tubular structure, wherein the wire is configured to extend at least partially through the opening and facilitate securing the end section over the opening. The tubular structure and stiffener wire include respective preset, expanded configurations and are configured to be constrained to respective reduced configurations for delivery to the target site and to at least partially return to their respective preset, expanded configurations at the target site when unconstrained.

Abstract: Embodiments of the present invention provide medical devices and methods for treating a target site within the body. For example, a medical device includes a multi-layered structure comprising an inner layer disposed within an outer layer, wherein each of the inner and outer layers has respective inner and outer surfaces. The multi-layered structure further comprises at least offset located between the inner and outer layers or formed in the inner and/or outer layers to define at least one gap therebetween such that a majority of the outer surface of the inner layer is spaced apart from the inner surface of the outer layer. The multi-layered structure is configured to be deployed within a lumen such that at least a portion of the outer layer is configured to engage the lumen and the at least one gap is configured to promote thrombosis between the inner and outer layers.

Abstract: Embodiments of the present invention provide medical devices and methods for treating a target site within the body, such as for treating vascular abnormalities. For example, one embodiment provides a stent graft including an occlusive material having a preset, overlapping configuration comprising at least three inverted overlapping layers that are folded over one another. The at least three inverted overlapping layers are configured to be separated and disposed within a catheter in a non-overlapping configuration and return to the preset, overlapping configuration when deployed from the catheter.

Abstract: Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with myocardial infarction (MI) and revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through a plurality of pacing leads introduced into a patient's body through a percutaneous transluminal vascular intervention (PTVI) catheter have a plurality of exit ports. In one embodiment, the exit ports are arranged for the pacing leads to enter multiple specified blood vessels.

Abstract: Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with myocardial infarction (MI) and revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto one or more percutaneous transluminal vascular intervention (PTVI) devices during the revascularization procedure. In one embodiment, a PTVI device includes an expandable distal end to provide a stable electrical contact between a pacing electrode and the vascular wall of a blood vessel when the distal end is placed in the blood vessel.

Abstract: Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with myocardial infarction (MI) and revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto one or more percutaneous transluminal vascular intervention (PTVI) devices during the revascularization procedure. In one embodiment, a PTVI device releases a conductive liquid to provide a conductive medium between a pacing electrode and tissue of pacing site.

Abstract: Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with myocardial infarction (MI) and revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through pacing electrodes incorporated onto percutaneous transluminal vascular intervention (PTVI) devices during the revascularization procedure. Examples of the PTVI devices include a guide catheter, a guide wire, and an angioplasty catheter such as a balloon catheter used in the revascularization procedure. The pacing electrodes are incorporated onto such PTVI devices in various ways.

Abstract: A multi-layer occluder for treating a target site within the body is provided. The occluder may include first and second layers. For example, the first layer may include braided strands of metallic material, and the second layer may include braided strands of polymeric material. At least one of the first or second layers may be configured to facilitate thrombosis.

Abstract: For weld bonding polymeric components, a bond monitoring device is utilized to sense emissivity from a bonding site to preferably determine the temperature of the material at the surface of the bonding site, in order to provide feedback information to a current generator that controls the thermal energy that is transferred to the bonding site. The bond monitoring device preferably comprises an infrared detector or pyrometer that determines the temperature at the surface of the bonding site by sensing the infrared radiation, which information is used to control current generation. The current generation device preferably comprises a radio-frequency current generator, which RF current is controllably used to create a magnetic field within a magnetic flux concentrator. When used with an mandrel of magnetically permeable material that is positioned close to the magnetic flux concentrator, the mandrel can generate resistive heat based directly on the supply of RF current.

Abstract: For weld bonding polymeric components, a bond monitoring device is utilized to sense emissivity from a bonding site to preferably determine the temperature of the material at the surface of the bonding site, in order to provide feedback information to a current generator that controls the thermal energy that is transferred to the bonding site. The bond monitoring device preferably comprises an infrared detector or pyrometer that determines the temperature at the surface of the bonding site by sensing the infrared radiation, which information is used to control current generation. The current generation device preferably comprises a radio-frequency current generator, which RF current is controllably used to create a magnetic field within a magnetic flux concentrator. When used with an mandrel of magnetically permeable material that is positioned close to the magnetic flux concentrator, the mandrel can generate resistive heat based directly on the supply of RF current.

Abstract: A medical device delivery system comprises an inner tube, a medical device disposed about a portion of the distal region of the inner tube, a medical device sheath disposed about the medical device, a medical device sheath retraction device extending proximally from the medical device sheath and an outer sheath disposed about a portion of the medical device sheath retraction device. The distal end of the outer sheath terminates at least one medical device length proximal of the medical device. The medical device sheath is movable relative to the outer sheath and relative to the inner tube.