Patents by Inventor Matthew C. Pelligrini

Matthew C. Pelligrini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods And Agents For Screening For Compounds Capable Of Modulating Gene Expression
    Publication number: 20150253304
    Abstract: The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.
    Type: Application
    Filed: May 22, 2015
    Publication date: September 10, 2015
    Applicant: PTC Therapeutics, Inc.
    Inventors: Liangxian Cao, Nikolai Naryshkin, Charles Romfo, Matthew C. Pelligrini, Anuradha Mehta, Panayiota Trifillis, Christopher R. Trotta
  • Cell Based Methods And Systems For The Identification Of Rna Regulatory Sequences And Compounds That Modulate Their Functions
    Publication number: 20080318222
    Abstract: The present invention is directed to an in vivo method for screening for and/or identifying RNA regulatory sequences involved in translational control. The method includes: culturing cells including: (i) a translational system; (ii) a reporter mRNA; and (iii) an RNA test sequence under suitable conditions for translation of the reporter mRNA, wherein the RNA test sequence is not attached to the reporter mRNA. The method also includes measuring the effect of the test sequence on the translation of the reporter mRNA, wherein a test sequence that modifies the translation of the reporter mRNA includes an RNA regulatory element. The invention also provides methods and systems for screening for and/or identifying test compounds that modulate the regulatory activity of an RNA regulatory sequence.
    Type: Application
    Filed: December 27, 2005
    Publication date: December 25, 2008
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Matthew C. Pelligrini, Christopher R. Trotta