Abstract: This invention is directed to genetically engineered B cells, wherein the B cell expresses and bears on its surface a chimeric B cell receptor, and wherein the genetically engineered B cell further expresses and secretes an antibody or cytokine.

Abstract: This invention provides multispecific antibodies that neutralize SARS-CoV2 and methods of use thereof. The antibodies described herein can be used to treat SARS-CoV2 infections and symptoms thereof.

Abstract: A computing system including a processor and a memory configured to: receive incoming data related to one or more quality assurance business processes; analyze the incoming data to determine data meeting flagging criteria for flagging the incoming data as flagged data, wherein the data meeting flagging criteria indicates that additional context is necessary with respect to the flagged data the incoming data includes a number of quality assurance reports generated within a given period and the flagging criteria includes a threshold number of quality assurance reports generated within the given period such that the incoming data is flagged if the number of reports generated within the given period exceeds the threshold; and automatically generate a context report based on the flagged data, wherein the context report includes, at least, the flagged data and context data that indicates specific flagging criteria of the flagged data.

Abstract: Conventional high performance computer connections are electron-based systems, which require the memory packages to be as close as mechanically possible to the computation engine. Low power and high bandwidth communication, e.g. photonic, links can drastically change the architecture of high-performance computers by eliminating the bottlenecks in communication and augment existing memory systems to allow them to be both high capacity and high bandwidth simultaneously.

Abstract: The present invention provides monoclonal antibodies that neutralize SARS-CoV2 and methods of use thereof. The antibodies described herein can be used to treat SARS-CoV2 infections and symptoms thereof.

Abstract: A snow blower including an auger housing, an auger rotatably positioned within the auger housing and configured to blow snow, a shaft attached to the auger and the auger housing, a chute attached to the auger housing and configured to direct the snow blown by the auger away from the snow blower, and at least one sensor configured to detect at least one of a rotational speed of the auger or the shaft and a load, torque, and/or thrust on the shaft or the auger housing. The data collected by the at least one sensor is used to determine an instantaneous flow rate of snow.

Abstract: An apparatus and method for a sleeve for use with a phacoemulsification handpiece, the sleeve having a body portion suitable for engaging a handpiece is disclosed. The tip portion of the sleeve may comprise at least one aspiration port and at least one rounded portion which may be suitable for use for surgery of the eye, and, more particularly, for use around the edge of a capsular bag.

Abstract: The present invention is directed to human monoclonal antibodies that bind to the cell-surface receptor, PDL-1 (programmed death ligand 1). The antibodies can be used to treat cancer and chronic viral infections.

Abstract: Biological research requires isolation and analysis of material, for example, RNA, DNA and protein, from tissue samples. The methods and compositions described herein allow for high resolution imaging of large and intact tissue samples, and subsequent isolation of material in a precise and location dependent-manner. The methods and compositions described herein may be used, for example, for biomarker discovery, identification of cell populations, pathology analysis, and generation of expression data in specific regions of interest.

Abstract: MUC1 is overexpressed in many cancers, including those of the lung, colon, breast, ovary, and pancreas. Aspects of the invention are directed towards the discovery of monoclonal antibodies and fragments thereof, such as a human single chain variable fragment (scFv), that recognizes human MUC1-SEA.

Abstract: The present invention is directed to human monoclonal antibodies that bind to the cell-surface receptor, PD-1 (programmed death 1). The antibodies can be used to treat cancer and chronic viral infections.

Abstract: The present invention is directed to human multispecific antibodies that bind to the cell-surface receptor, PD-1 (programmed death 1). The antibodies can be used to treat cancer and chronic viral infections.

Abstract: A digital-to-analog converter (DAC) system preferably includes one or more optical modulators and can optionally include one or more electronic DAC arrays. A method for digital-to analog conversion preferably includes receiving digital inputs and providing analog optical outputs. The method for digital-to analog conversion is preferably performed using the DAC system.

Abstract: This invention is directed to chimeric antigen receptors and cells comprising the same, wherein the cells further secrete monoclonal antibodies locally at a tumor site.

Abstract: A digital-to-analog converter (DAC) system preferably includes one or more optical modulators and can optionally include one or more electronic DAC arrays. A method for digital-to analog conversion preferably includes receiving digital inputs and providing analog optical outputs. The method for digital-to analog conversion is preferably performed using the DAC system.

Abstract: A digital-to-analog converter (DAC) system preferably includes one or more optical modulators and can optionally include one or more electronic DAC arrays. A method for digital-to analog conversion preferably includes receiving digital inputs and providing analog optical outputs. The method for digital-to analog conversion is preferably performed using the DAC system.

Abstract: A system for generating a storage-efficient data structure representing a plurality of inter-related data tables and adapted for use in data processing. The system configured to receive input data and generate a graph database having edges and vertices. Each inter-related data table of a plurality of inter-related data tables is received as input data and defines a corresponding vertex of the vertices. The edges defining pairwise relationships between the vertices based on one or more common elements of a corresponding pair of data tables. A reduced graph database is generated, as well as its connected-components. A partition defined by an equivalence relation on the graph database is used to generate the reduced graph database. Each set of the plurality of sets of the partition is represented by a single vertex of the corresponding set. An output data structure indicative of the connected-components, or additionally or alternatively, the irreducible generators, is generated.