Abstract: A method of therapy escalation for patients with diabetes includes receiving glucose data of a user from an in vivo glucose monitoring device, receiving first therapy information of a first therapy, wherein the first therapy includes basal insulin, calculating one or more glucose metrics based on the received glucose data, titrating a dose of the basal insulin based on the one or more glucose metrics, and determining overbasalization based on one or more of the glucose data and the first therapy information. Advantageously the system can regularly monitor glucose control of a user, detect overbasalization, provide frequent therapy intervention and adjustment, decrease a duration of intervention, and increase user adherence, outcomes, and satisfaction.

Abstract: The invention provides an insertion device for insertion of conduits into a body that, before and following deployment of the conduit into the body, has no components that require insertion into or removal from the device. Additionally, the device includes a component that not only prevents re-use or reopening of the device once it is activated, but also provides feedback to the user in the form of a resistance force to activation that must be overcome by the user to deploy the conduit.

Abstract: The invention relates to a mechanical drive system for a medical infusion device. The disclosed drive system employs a flexible tape with recesses or holes that are configured to mate with tabs or protrusions on a gear to advance the rotation of the gear at a rate determined by the pattern of recesses or holes on the flexible tape.