Abstract: An ejector mechanism of a droplet delivery device includes a piezoelectric actuator coupled to an acoustic horn and an aperture plate including a plurality of openings. At least the fluid entrance side of one or more of the plurality of openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets such that at least about 50% of the droplets have an average ejected droplet diameter of less than about 6 microns during use. A sealing mechanism is provided at an interface of the aperture plate and a detachable fluid cartridge.

Abstract: A method of treating a lead zirconium titanate ceramic transducer, such as for use in droplet delivery devices, includes washing the lead zirconium titanate ceramic transducer with an HCl solution and coating the transducer with material that prevents lead from leaching into fluid contacting the transducer.

Abstract: A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.

Abstract: Embodiments of the present disclosure provide compositions and methods for administering cannabinoids to the respiratory system of a subject. Accordingly, embodiments herein include compositions comprising one or more cannabinoids and pharmaceutical compositions comprising one or more cannabinoids. Embodiments herein also include methods of making compositions herein, methods of delivering compositions herein, and methods of treating a subject by administering one or more compositions herein.

Abstract: A droplet delivery device includes an ejection channel and droplets outlet, a mesh positioned in the ejection channel and configured to produce an ejected stream of droplets through openings in the mesh, an airflow path in communication with the ejection channel and the mesh, and a heating element positioned in the airflow path.

Abstract: A droplet delivery device includes an ejector bracket including a mesh with a membrane operably coupled to a vibrating member tip that is coupled to an electronic transducer with the membrane between and contacting both the vibrating member tip and the mesh to produce droplets, such as for inhalation by a user of the droplet delivery device.

Abstract: A droplet delivery device includes an ejector mesh communicating with a fluid reservoir via a first pathway that includes wicking material and a second pathway that is free of wicking material with droplets produced by the mesh ejected out of a droplets outlet of the device.

Abstract: Embodiments of the present disclosure provide compositions and methods for administering nicotine to the respiratory system of a subject. Accordingly, embodiments herein include compositions comprising nicotine that includes nicotine in combination with L-lactic acid and water. Embodiments herein also include methods of making compositions herein, methods of delivering compositions herein, and methods of treating a subject by administering one or more compositions herein.

Abstract: A droplet delivery device includes a mesh with a plurality of opening supported by a mesh carrier in the airflow path of the droplet delivery device. The mesh is vibrated by an electronic transducer and produce droplets from a fluid supply with mesh carrier aiding the production of the droplets.

Abstract: A droplet delivery device includes a droplets outlet coupled to a one-piece and removable container assembly, wherein the container assembly includes a mesh and a membrane, and wherein the mesh includes a plurality of openings formed through the mesh's thickness, a reservoir in fluid communication with the container assembly and configured to supply a volume of fluid, and a vibrating member coupled to a power source and positioned to cooperate with the membrane and mesh to generate an ejected stream of droplets through the mesh.

Abstract: A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.

Abstract: A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.

Abstract: A droplet delivery device includes an ejector mechanism with an ejector mesh or similar substrate with apertures that is treated by one or more of coatings, roughening, metal layer deposition and laser ablation to provide desirable production and size of droplets, such as in an inhaled aerosol from the device.

Abstract: A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.

Abstract: An ejector mechanism, droplet delivery device and related methods or delivering small droplets to the respiratory system of a users disclosed. The ejector mechanism comprises a piezoelectric actuator and an aperture plate, the aperture plate having and a plurality of openings formed through its thickness, wherein at least the fluid entrance side of one or more of said openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets during use. The droplet delivery device is automatically breath actuated by a user when the differential pressure sensor senses a predetermined pressure change. The ejector mechanism is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range having a diameter of less than about 4 um so as to target the respiratory system of the user.