Abstract: In accordance with various embodiments of the disclosed subject matter, a system, device, apparatus and method for calibrating a split bit digital readout to avoid misalignment of the least significant counter bit (i.e., the LSB of the M most significant bits) and most significant residual bit (i.e. the MSB of the N least significant bits). For example, various embodiments provide a field programmable gate array (FPGA), digital signal processing (DSP) function and the like configured to calibrate one or many split bit digital readouts such as may exist on a digital pixel sensor (DPS) or other device.