Patents by Inventor Matthew D. Layne

Matthew D. Layne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12139542
    Abstract: The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compostions, methods and kits comprising an inhibitor of a portion of the N-terminal pro-fibrotic domain (PFD) of Aortic Carboxypeptidase-Like Protein (ACLP), and in some embodiments, in combination with an inhibitor of the discoidin (DS) domain of ACLP, for use in methods for the treatment of fibroproliferative diseases and cancer, and inhibition of ACLP-mediated activation of a member of the TGF? receptor superfamily.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: November 12, 2024
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Matthew D. Layne, Kathleen E. Tumelty, Robert Lafyatis
  • Patent number: 7094878
    Abstract: The invention features a aortic carboxypeptidase-like polypeptide (ACLP), DNA encoding ACLP, and methods of detecting genetic alterations associated with abdominal wall defects.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: August 22, 2006
    Assignee: President and Fellows of Harvard College
    Inventors: Mu-En Lee, Matthew D. Layne, Shaw-Fang Yet
  • Publication number: 20030084464
    Abstract: The invention features a aortic carboxypeptidase-like polypeptide (ACLP), DNA encoding ACLP, and methods of detecting genetic alterations associated with abdominal wall defects.
    Type: Application
    Filed: September 10, 2002
    Publication date: May 1, 2003
    Inventors: Mu-En Lee, Matthew D. Layne, Shaw-Fang Yet
  • Patent number: 6468766
    Abstract: The invention features a aortic carboxypeptidase-like polypeptide (ACLP), DNA encoding ACLP, and methods of detecting genetic alterations associated with abdominal wall defects.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: October 22, 2002
    Assignee: President and Fellows of Harvard College
    Inventors: Mu-En Lee, Matthew D. Layne, Shaw-Fang Yet