Patents by Inventor Matthew D. Phaneuf
Matthew D. Phaneuf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200276379Abstract: A tissue compression cuff comprises a first fastening portion defining one or more openings and at least one band. The at least one band comprises a first end extending from the first fastening portion at a first end, and an opposing second end, the at least one band defining a first diameter at the first end and a second diameter at the second end. The first diameter is larger than the second diameter. A second fastening portion is positioned at the opposing second end of the at least one band. The second end of the at least one band is configured to be inserted through the one or more openings of the first fastening portion. The tissue compression cuff is sized and configured to reduce blood flow through an arteriovenous fistula and made from an electrospun textile made up of biocompatible nanofibers.Type: ApplicationFiled: February 27, 2020Publication date: September 3, 2020Inventors: Matthew D. Phaneuf, Dirk Hentschel, John Lucas, III
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Patent number: 10441550Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment.Type: GrantFiled: February 18, 2016Date of Patent: October 15, 2019Assignees: BIOSURFACES, INC., RHODE ISLAND BOARD OF EDUCATION, CLEMSON UNIVERSITYInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Patent number: 10328032Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: GrantFiled: June 2, 2014Date of Patent: June 25, 2019Assignees: BIOSURFACES, INC., RHODE ISLAND BOARD OF EDUCATION, CLEMSON UNIVERSITYInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Publication number: 20160158160Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment.Type: ApplicationFiled: February 18, 2016Publication date: June 9, 2016Applicants: BioSurfaces, Inc., Clemson University, Rhode Island Board of EducationInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Publication number: 20140271795Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: ApplicationFiled: June 2, 2014Publication date: September 18, 2014Applicants: BioSurfaces, Inc., Clemson University, Rhode Island Board of EducationInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Patent number: 8771582Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: GrantFiled: November 23, 2011Date of Patent: July 8, 2014Assignees: BioScurfaces, Inc., Clemson University, Rhode Island Board of EducationInventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Patent number: 8691543Abstract: The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.Type: GrantFiled: November 26, 2010Date of Patent: April 8, 2014Assignee: Worcester Polytechnic InstituteInventors: Glenn Gaudette, Matthew D. Phaneuf, Syed Ali, Brian Almeida, Helena Alfonzo, Katie Flynn
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Publication number: 20140054828Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: ApplicationFiled: November 23, 2011Publication date: February 27, 2014Inventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Publication number: 20120068384Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.Type: ApplicationFiled: November 23, 2011Publication date: March 22, 2012Inventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Publication number: 20110142804Abstract: The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.Type: ApplicationFiled: November 26, 2010Publication date: June 16, 2011Applicant: Worcester Polytechnic InstituteInventors: Glenn Gaudette, Matthew D. Phaneuf, Syed Ali, Brian Almeida, Helena Alfonzo, Katie Flynn
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Patent number: 7413575Abstract: The present invention provides a bioactive, small-diameter (typically less than 6 mm in internal diameter) vascular graft prosthesis, and is a textile conduit preferably manufactured using a novel electrospinning perfusion methodology. One preferred embodiment is a nanofibrous biocomposite textile conduit which comprises a prepared liquid admixture of polyester (Dacron), a biodurable implantable synthetic polymer, and Type IV collagen, an extracellular matrix protein. This prepared admixture and blending of diverse fibrous matter is utilized in a novel electrospinning perfusion process to form a small-diameter (less than 6 mm) fabricated textile conduit, a discrete article of manufacture, which then serves as an antecedent tangible workpiece for a subsequently-made prosthetic vascular graft construct.Type: GrantFiled: August 25, 2005Date of Patent: August 19, 2008Inventors: Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
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Patent number: 7037527Abstract: The invention features a method of treating polyester material to generate functional carboxylic acid and amine groups. These functional groups can be used as sites for covalent bond formation to attach chemical or biological moieties. This bifunctionalized polyester polymer can be used in any medical application in which biocompatible polymers are used.Type: GrantFiled: January 27, 2003Date of Patent: May 2, 2006Assignees: University of Rhode Island, Beth Israel Deaconess Medical Center, BioMod SurfacesInventors: Martin J. Bide, Matthew D. Phaneuf, William C. Quist, Donald J. Dempsey, Frank W. LoGerfo
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Publication number: 20040202700Abstract: The present invention provides a method for making an infection-preventive fabric article which is suitable for a non-invasive or topical usage as a medical treatment fabric, or as a health care product, or as a protective appliance. The method of manufacture applies broadly to any and all non-woven and woven fabrics including any and all cloths, gauzes, and/or films comprised in whole or in part of fibrous matter matrices or of discrete fibers; and provides prophylactic and protective antimicrobial/anti-fungal articles for use in a wide range and variety of biomedical, environmental, and safety-hazard applications.Type: ApplicationFiled: September 4, 2003Publication date: October 14, 2004Inventors: Matthew D. Phaneuf, William C. Quist, Martin J. Bide, Frank LoGerfo
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Patent number: 6743253Abstract: Provided is a biocompatible device which has been coated or sealed with a polyether or polyether/carbonate based urethane polymer that contains functional groups (e.g. carboxylic acid groups) which are capable of serving as anchor sites for protein binding.Type: GrantFiled: February 28, 2001Date of Patent: June 1, 2004Assignees: BioMod Surfaces, Beth Israel Deaconess Medical CenterInventors: Matthew D. Phaneuf, Donald J. Dempsey, William C. Quist, Frank W. Logerfo
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Publication number: 20040091604Abstract: The present invention is a broadly applicable methodology for making a bioactive titanium surface which would be clinically-acceptable and effective as either an anti-thrombin, thrombolytic or growth promoting surface coating, or any combination of these. The bioactive surface can be prepared using any material comprising titanium in whole or in part; is suitable for inclusion upon the exposed surfaces of surgically implantable prostheses comprising titanium; offers a means for avoiding systemic anticoagulation therapy to reduce thrombus formation and thromboembolism in the living subject receiving a surgically implanted prosthesis; and provides a means to induce cellular attachment and proliferation onto the titanium surface of the implant.Type: ApplicationFiled: May 15, 2003Publication date: May 13, 2004Inventors: Donald J. Dempsey, William C. Quist, Lori M. Anderson, Matthew D. Phaneuf, Frank W. LoGerfo
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Publication number: 20030216524Abstract: The invention features a method of treating polyester material to generate functional carboxylic acid and amine groups. These functional groups can be used as sites for covalent bond formation to attach chemical or biological moieties. This bifunctionalized polyester polymer can be used in any medical application in which biocompatible polymers are used.Type: ApplicationFiled: January 27, 2003Publication date: November 20, 2003Inventors: Martin J. Bide, Matthew D. Phaneuf, William C. Quist, Donald J. Dempsey, Frank W. LoGerfo
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Patent number: 6592885Abstract: The present invention provides a method for making an infection-resistant fabricated textile article which is suitable for any in-vivo usage either as a topical bandage, on an implantable configured construct, or as part of a prosthetic mechanical appliance. The method of manufacture applies broadly to any and all fabrics, cloths, gauzes, and/or films comprised in whole or in part of fibers; and provides an infection-resistant textile of valued use in a wide range and variety of medical applications.Type: GrantFiled: June 7, 2001Date of Patent: July 15, 2003Inventors: Matthew D. Phaneuf, William C. Quist, Martin J. Bide, Frank W. LoGerfo
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Publication number: 20030091616Abstract: The present invention provides a method for making an infection-resistant fabricated textile article which is suitable for any in-vivo usage either as a topical bandage, on an implantable configured construct, or as part of a prosthetic mechanical appliance. The method of manufacture applies broadly to any and all fabrics, cloths, gauzes, and/or films comprised in whole or in part of fibers; and provides an infection-resistant textile of valued use in a wide range and variety of medical applications.Type: ApplicationFiled: June 7, 2001Publication date: May 15, 2003Inventors: Matthew D. Phaneuf, William C. Quist, Martin J. Bide, Frank W. LoGerfo
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Publication number: 20010053933Abstract: Provided is a biocompatible device which has been coated or sealed with a polyether or polyether/carbonate based urethane polymer that contains functional groups (e.g. carboxylic acid groups) which are capable of serving as anchor sites for protein binding.Type: ApplicationFiled: February 28, 2001Publication date: December 20, 2001Inventors: Matthew D. Phaneuf, Donald J. Dempsey, William C. Quist, Frank W. Logerfo
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Publication number: 20010049422Abstract: The invention provides urethane polymers bonded to therapeutically active compounds, such as antibiotics. The invention also features methods of applying therapeutically active compounds to polyurethane polymers using textile dyeing. These polymers may be used in a variety of clinical applications.Type: ApplicationFiled: April 13, 2001Publication date: December 6, 2001Inventors: Matthew D. Phaneuf, William C. Quist, Michael Szycher, Martin J. Bide, Frank W. LoGerfo