Patents by Inventor Matthew D. Rand

Matthew D. Rand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Activated amino- and carboxy-terminal forms of Notch
    Patent number: 8222213
    Abstract: The present invention is directed to methods for detecting or measuring Notch activation by observing or measuring the appearance of Notch on the cell surface or by observing or measuring Notch cleavage products that are indicative of Notch activation. The present invention is also directed to methods for detecting a molecule that modulates Notch activation by observing or measuring a change in the amount of Notch expressed on the cell surface or a change in the amount or pattern of Notch cleavage products. The present invention is also directed to a substantially purified activated heterodimeric form of Notch and components thereof and pharmaceutical compositions and kits thereof. The present invention is based, at least in part, on the discovery that Notch in its active form, i.e.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: July 17, 2012
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Huilin Qi, Matthew D. Rand
  • DEVICE AND NON-TOXIC COMPOSITIONS AND METHODS FOR PERMEABILIZATION OF DROSOPHILA EMBRYOS
    Publication number: 20120009590
    Abstract: The invention provides compositions and methods for permeabilizing insect embryos by removing the waxy layer of the shell using a solution containing a non-toxic cyclic terpene and a non-toxic surfactant, preferably a non-ionic surfactant. The invention further provides kits to practice the method of the invention. The invention also provides methods for toxicology and other high throughput screening method including the compositions and methods of embryo permeabilization provided herein.
    Type: Application
    Filed: January 11, 2010
    Publication date: January 12, 2012
    Applicant: The University of Vermont and State Agriculture College
    Inventor: Matthew D. Rand
  • Activated Forms Of Notch And Methods Based Thereon
    Publication number: 20110028383
    Abstract: The present invention is directed to methods for detecting or measuring Notch activation by observing or measuring the appearance of Notch on the cell surface or by observing or measuring Notch cleavage products that are indicative of Notch activation. The present invention is also directed to methods for detecting a molecule that modulates Notch activation by observing or measuring a change in the amount of Notch expressed on the cell surface or a change in the amount or pattern of Notch cleavage products. The present invention is also directed to a substantially purified activated heterodimeric form of Notch and components thereof and pharmaceutical compositions and kits thereof. The present invention is based, at least in part, on the discovery that Notch in its active form, i.e.
    Type: Application
    Filed: May 27, 2010
    Publication date: February 3, 2011
    Inventors: Spyridon Artavanis-Tsakonas, Huilin Qi, Matthew D. Rand
  • Methods for identifying modulators of Notch activation
    Patent number: 7727732
    Abstract: The present invention is directed to methods for detecting or measuring Notch activation by observing or measuring the appearance of Notch on the cell surface or by observing or measuring Notch cleavage products that are indicative of Notch activation. The present invention is also directed to methods for detecting a molecule that modulates Notch activation by observing or measuring a change in the amount of Notch expressed on the cell surface or a change in the amount or pattern of Notch cleavage products. The present invention is also directed to a substantially purified activated heterodimeric form of Notch and components thereof and pharmaceutical compositions and kits thereof. The present invention is based, at least in part, on the discovery that Notch in its active form, i.e.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: June 1, 2010
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Huilin Qi, Matthew D. Rand
  • Activated forms of notch and methods based thereon
    Patent number: 6692919
    Abstract: The present invention is directed to methods for detecting or measuring Notch activation by observing or measuring the appearance of Notch on the cell surface or by observing or measuring Notch cleavage products that are indicative of Notch activation. The present invention is also directed to methods for detecting a molecule that modulates Notch activation by observing or measuring a change in the amount of Notch expressed on the cell surface or a change in the amount or pattern of Notch cleavage products. The present invention is also directed to a substantially purified activated heterodimeric form of Notch and components thereof and pharmaceutical compositions and kits thereof. The present invention is based, at least in part, on the discovery that Notch in its active form, i.e.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: February 17, 2004
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Huilin Qi, Matthew D. Rand