Patents by Inventor Matthew D. Scharff

Matthew D. Scharff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutations caused by activation-induced cytidine deaminase
    Publication number: 20110143440
    Abstract: Methods for causing mutations in genes expressed in eukaryotic cells are provided. The methods involve expressing an activation-induced cytidine deaminase (AID) in the cells. The mutated genes can be any gene that is operably linked to a promoter, where the gene is within about 2 kilobases of the promoter. Examples include antibody genes. Also provided are cells expressing AID. The cells can be from any eukaryote, and include hybridoma cells and myeloma fusion partners.
    Type: Application
    Filed: July 13, 2010
    Publication date: June 16, 2011
    Inventors: Alberto Martin, Matthew D. Scharff
  • Peptides for detecting anti-double stranded DNA antibody and uses thereof
    Patent number: 7517657
    Abstract: The present invention provides a method for identifying a peptide which binds to an anti-double stranded DNA antibody. The present invention also provides a class of peptides identified by the method of the present invention which bind to anti-double stranded DNA antibodies and compositions containing these peptides. The present invention also provides methods for the diagnosis and treatment of systemic lupus erythematosus utilizing the peptides of the present invention.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: April 14, 2009
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Bruce D. Gaynor, Betty A. Diamond, Matthew D. Scharff, Philippe Valadon
  • Peptides for the treatment and diagnosis of systemic lupus erythematosus
    Patent number: 6932970
    Abstract: The present invention provides a method for identifying a peptide which binds to an anti-double stranded DNA antibody. The present invention also provides a class of peptides identified by the method of the present invention which bind to anti-double stranded DNA antibodies and compositions containing these peptides. The present invention also provides methods for the diagnosis and treatment of systemic lupus erythematosus utilizing the peptides of the present invention.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: August 23, 2005
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Bruce D. Gaynor, Betty A. Diamond, Matthew D. Scharff, Philippe Valadon
  • Antibodies to polysaccharide of C. neoformans
    Publication number: 20030103977
    Abstract: This invention relates to monoclonal antibodies which bind to non-enhancing protective epitopes on serotype A, B, C and D strains of C. neoformans, such protective epitopes containing acetyl groups in the polysaccharide of the epitopes. Other monoclonal antibodies of this invention are serotype specific, and bind to acetyl groups on polysaccharide capsule protective epitopes of serotype D strain C. neoformans only. This invention further relates to methods for producing these monoclonal antibodies. These monoclonal antibodies may be passively administered to treat and prevent cryptococcal infection, such as Cryptococcal meningitis, in immunosuppressed patients. These monoclonal antibodies may also be used for detection of fungal infection, for the development of diagnostic serotyping of clinical isolates, and as therapeutic adjuncts to anti-fungal antibiotic therapy.
    Type: Application
    Filed: September 24, 2002
    Publication date: June 5, 2003
    Inventors: Arturo Casadevall, Matthew D. Scharff, Jean Mukherjee
  • Peptides which bind to anti-double stranded DNA antibody
    Patent number: 6001964
    Abstract: The present invention provides a method for identifying a peptide which binds to an anti-double stranded DNA antibody. The present invention also provides a class of peptides identified by the method of the present invention which bind to anti-double stranded DNA antibodies and compositions containing these peptides. The present invention also provides methods for the diagnosis and treatment of systemic lupus erythematosus utilizing the peptides of the present invention.
    Type: Grant
    Filed: September 20, 1995
    Date of Patent: December 14, 1999
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Bruce D. Gaynor, Betty A. Diamond, Matthew D. Scharff, Philippe Valadon