Abstract: The disclosure is directed to a monoclonal antibody. or an antigen-binding fragment thereof. directed against fibrils of amyloid beta (A?) peptides, as well as a method of treating and diagnosing neurodegenerative diseases using the monoclonal antibody.

Abstract: A method of detecting passage of a particle into a target location includes receiving a sample on a die including a microfluidic chamber, the microfluidic chamber including a microfluidic path coupling a reservoir to a foyer, and moving the sample from the reservoir to the foyer by firing a nozzle fluidically coupled to the foyer. The method further includes detecting passage of a particle of the sample from the reservoir to the foyer via a first sensor disposed within the microfluidic path, and detecting passage of the particle into the target location via a second sensor disposed between the first sensor and the nozzle. The method includes recording in a dispense map, an indication of whether the target location includes a single particle or multiple particles based on signals measured by the first sensor and the second sensor.

Abstract: A vehicle has an engine, an exhaust aftertreatment system, an electric machine, and a controller configured to, in response to an actual engine torque output being less than an inferred engine torque, shut down the engine. A vehicle has an engine, an exhaust aftertreatment system, an electric machine, and a controller configured to, in response to an actual engine torque output being less than a first threshold and a torque request to the engine being greater than a second threshold, set a diagnostic code. A method includes receiving an actual engine torque output, receiving an engine torque request, and shutting down the engine when the actual engine torque output is less than a first threshold and the engine torque request is greater than a second threshold for a predetermined time period to limit temperature increase of a catalyst.

Abstract: Embodiments herein disclose a system for enabling purchases spanning multiple categories of offerings in a common purchase made with the system. The system splits or separates a common purchase spanning multiple categories of offerings into purchase orders directed to individual categories of offerings and forwards the purchase orders to respective entities providing the offerings for fulfillment.

Abstract: Methods and systems are provided for mitigating loss of engine torque due to cavitation in a fuel pump. One example approach is adjusting engine operation or fuel pump operation based on ambient conditions and a measured engine torque being lower than a desired engine torque after a pre-determined duration. The ambient conditions may include one or more of ambient temperature being higher than a temperature threshold, barometric pressure lower than a threshold pressure, and fuel volatility higher than a threshold volatility.

Abstract: A vehicle has an engine, an exhaust aftertreatment system, an electric machine, and a controller configured to, in response to an actual engine torque output being less than an inferred engine torque, shut down the engine. A vehicle has an engine, an exhaust aftertreatment system, an electric machine, and a controller configured to, in response to an actual engine torque output being less than a first threshold and a torque request to the engine being greater than a second threshold, set a diagnostic code. A method includes receiving an actual engine torque output, receiving an engine torque request, and shutting down the engine when the actual engine torque output is less than a first threshold and the engine torque request is greater than a second threshold for a predetermined time period to limit temperature increase of a catalyst.

Abstract: A control system for a compressor is provided. The control system includes a controller and first and second control portions. The first control portion is configured to assess an actual temperature of an evaporator and a target temperature of the evaporator and to generate a first compressor speed command signal. The second control portion includes a pressure calibration value and is configured to receive a pressure reading of the climate system, to compare the pressure reading to the pressure calibration value and to generate a second compressor speed command signal. The controller device includes data and is configured to receive the first compressor speed command signal and the second compressor speed command signal and to transmit a control signal to the compressor for causing the compressor to operate at a commanded compressor speed based on the first compressor speed command signal, the second compressor speed command signal, and the data.

Abstract: A control system and method for controlling a hybrid electric vehicle powertrain with mechanical and electro-mechanical power sources that use an intelligent controller adapted to reduce driveline oscillations while minimizing hybrid vehicle battery limit violations. Damping of driveline torque oscillations is accomplished and violations of battery power limits are avoided by filtering estimated engine power.

Abstract: A vehicle has an engine, an exhaust aftertreatment system, an electric machine, and a controller configured to, in response to an actual engine torque output being less than an inferred engine torque, shut down the engine. A vehicle has an engine, an exhaust aftertreatment system, an electric machine, and a controller configured to, in response to an actual engine torque output being less than a first threshold and a torque request to the engine being greater than a second threshold, set a diagnostic code. A method includes receiving an actual engine torque output, receiving an engine torque request, and shutting down the engine when the actual engine torque output is less than a first threshold and the engine torque request is greater than a second threshold for a predetermined time period to limit temperature increase of a catalyst.

Abstract: Methods and systems are provided for mitigating loss of engine torque due to cavitation in a fuel pump. One example approach is adjusting engine operation or fuel pump operation based on ambient conditions and a measured engine torque being lower than a desired engine torque after a pre-determined duration. The ambient conditions may include one or more of ambient temperature being higher than a temperature threshold, barometric pressure lower than a threshold pressure, and fuel volatility higher than a threshold volatility.

Abstract: A method includes receiving, at a computing device, vehicle condition data from a vehicle monitoring system of a vehicle. The method also includes analyzing the vehicle condition data based on a trigger table, and based on a determination that the vehicle condition data satisfies a particular trigger condition specified in the trigger table, adding an entry in an alert evaluation queue.

Abstract: Methods are provided for performing diagnostic routines in a hybrid vehicle. In one example approach, a method for operating a hybrid vehicle comprises inhibiting engine shutdown and enabling deceleration fuel shut off to perform a monitoring test while a vehicle speed is above a threshold speed.

Abstract: Methods and systems are provided for diagnosing an intake air temperature sensor in a hybrid electric vehicle. An engine temperature is compared to each of an intake air temperature sensed before an engine start but after sufficient engine soak, as well as an intake air temperature sensed after selected vehicle operating conditions have elapsed since the engine start. Based on discrepancies between the air temperature and the engine temperature, degradation of the sensor is determined.

Abstract: Methods are provided for holding an engine steady during a drive cycle to complete one or more diagnostic routines. The engine may be held steady while an operator torque demand varies if a sufficient number of diagnostic routines need to be completed and are enabled for completion. By holding the engine steady, an accuracy and completion of the diagnostic routines is improved.

Abstract: Methods are provided for performing diagnostic routines in a hybrid vehicle. In one example approach, a method for operating a hybrid vehicle comprises inhibiting engine shutdown and enabling deceleration fuel shut off to perform a monitoring test while a vehicle speed is above a threshold speed.

Abstract: Location information may be used to adjust the engine start/stop characteristics of a hybrid electric vehicle (HEV) in order to increase the amount of electric vehicle (EV) mode driving, particularly near a destination in which an ignition-off event may occur. Common ignition-off locations may be learned and stored in a database along with the number of ignition-off occurrences associated with each learned location. The vehicle may calculate current distance to a nearest ignition-off location stored in the database using positioning system coordinates and may determine whether to adjust one or more engine pull-ups based at least in part on the distance and the corresponding number of ignition-off occurrences.

Abstract: A method includes receiving, at a computing device, vehicle condition data from a vehicle monitoring system of a vehicle. The method also includes analyzing the vehicle condition data based on a trigger table, and based on a determination that the vehicle condition data satisfies a particular trigger condition specified in the trigger table, adding an entry in an alert evaluation queue.

Abstract: Systems and methods for aircraft cabin noise analysis are disclosed. In one embodiment, a computer based system to monitor vehicle conditions comprises a trigger table stored in a tangible computer readable memory which stores at least one set of logic conditions which may trigger directive to analyze if alert conditions exist. The system further comprises a trigger processor to receive one or more data streams comprising vehicle condition data for a monitored vehicle and transmit the directive to analyze alert logic to an alert evaluation queue when the vehicle condition data satisfies the at least one set of logic conditions in the trigger table, and an alert evaluation processor to execute a stand-alone program to analyze vehicle data and generate an alert when the vehicle condition data satisfies the at least one set of alert conditions. In some embodiments, the system may be implemented in a computing system or as logic instructions recorded on a computer readable medium.

Abstract: A vehicle has an engine, an exhaust aftertreatment system, an electric machine, and a controller configured to, in response to an actual engine torque output being less than an inferred engine torque, shut down the engine. A vehicle has an engine, an exhaust aftertreatment system, an electric machine, and a controller configured to, in response to an actual engine torque output being less than a first threshold and a torque request to the engine being greater than a second threshold, set a diagnostic code. A method includes receiving an actual engine torque output, receiving an engine torque request, and shutting down the engine when the actual engine torque output is less than a first threshold and the engine torque request is greater than a second threshold for a predetermined time period to limit temperature increase of a catalyst.

Abstract: Methods are provided for holding an engine steady during a drive cycle to complete one or more diagnostic routines. The engine may be held steady while an operator torque demand varies if a sufficient number of diagnostic routines need to be completed and are enabled for completion. By holding the engine steady, an accuracy and completion of the diagnostic routines is improved.