Patents by Inventor Matthew D. Weitzman

Matthew D. Weitzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein VII Fragments and Methods of Use Thereof for the Treatment of Inflammatory Disorders
    Publication number: 20190276499
    Abstract: Compositions and methods for treating inflammation are disclosed. More specifically, the invention provides biologically active fragments of protein VII from human adenovirus serotypes useful for reducing inflammatory symptoms.
    Type: Application
    Filed: June 22, 2017
    Publication date: September 12, 2019
    Inventors: Matthew D. Weitzman, Daphne C. Avgousti, Christin Herrmann, Andrew J. Paris, G. Scott Worthen
  • Methods of using adeno-associated virus rep protein
    Patent number: 6821511
    Abstract: A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep protein (or a nucleic acid sequence encoding an adeno-associated virus rep protein) and a genetic construct including at least one DNA sequence encoding a protein or polypeptide or genetic transcript of interest and a promoter controlling the at least one DNA sequence. The genetic construct also includes a first adeno-associated virus ITR or protein or derivative thereof and a second adeno-associated virus ITR or a portion or derivative thereof. The first and second adeno-associated virus ITRs or portions or derivatives thereof flank the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest and the promoter controlling the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: November 23, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert M. Kotin, Brian Safer, John A. Chiorini, Matthew D. Weitzman, Roland A. Owens, Stephen M. Wiener
  • Method of identifying cellular regulators of adeno-associated virus (AAV)
    Publication number: 20020182595
    Abstract: The present invention relates to a genetic screening assay to identify molecules that interact with a viral regulatory element. The viral regulatory element may be derived from an adeno associated virus (AAV), and may optionally contain at least one inverted terminal repeats (ITR) or one or more regions thereof. The construct containing the viral regulatory sequence is linked to a reporter gene so that the reporter gene will be expressed in the presence of proteins or other molecules that bind to the viral regulatory element. The assay is beneficial for analyzing molecules that bind to viral regulatory regions, and may be also useful as an assay kit to examine such interactions.
    Type: Application
    Filed: April 29, 2002
    Publication date: December 5, 2002
    Inventors: Matthew D. Weitzman, Anton J. Cathomen
  • Lipid vesicles containing adeno-associated virus Rep protein for transgene integration and gene therapy
    Publication number: 20020012997
    Abstract: A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep protein (or a nucleic acid sequence encoding an adeno-associated virus rep protein) and a genetic construct including at least one DNA sequence encoding a protein or polypeptide or genetic transcript of interest and a promoter controlling the at least one DNA sequence. The genetic construct also includes a first adeno-associated virus ITR or protein or derivative thereof and a second adeno-associated virus ITR or a portion or derivative thereof. The first and second adeno-associated virus ITRs or portions or derivatives thereof flank the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest and the promoter controlling the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest.
    Type: Application
    Filed: August 3, 2001
    Publication date: January 31, 2002
    Inventors: Robert M. Kotin, Brian Safer, John A. Chiorini, Matthew D. Weitzman, Roland A. Owens, Stephen M. Wiener
  • Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
    Patent number: 6342390
    Abstract: A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep protein (or a nucleic acid sequence encoding an adeno-associated virus rep protein) and a genetic construct including at least one DNA sequence encoding a protein or polypeptide or genetic transcript of interest and a promoter controlling the at least one DNA sequence. The genetic construct also includes a first adeno-associated virus ITR or protein or derivative thereof and a second adeno-associated virus ITR or a portion or derivative thereof. The first and second adeno-associated virus ITRs or portions or derivatives thereof flank the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest and the promoter controlling the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: January 29, 2002
    Assignee: The United States of America as represented by the Secretary of Health and Human Services
    Inventors: Stephen M. Wiener, John A. Chiorini, Brian Safer, Robert M. Kotin, Matthew D. Weitzman, Roland A. Owens