Abstract: A MAP and applicator system can include a MAP and an applicator. The MAP can include a backing and a plurality of microneedles extending from the backing. The microneedles can include tips with a GLP-1 agonist; and a water-soluble base configured to at least partially dissolve upon contact with a bodily fluid of a subject causing the tip to be released below the skin. The applicator is configured to maintain the MAP; in response to an activation mechanism being activated, release a piston downward into the MAP; and push, via the piston, the MAP downward onto the skin surface of the subject such that the plurality of microneedles penetrate the skin surface and are delivered. Apexes of the microneedles are delivered to the subject at a depth of at least about 600 ?m and at least about 70% of the GLP-1 is delivered after release of tips of the microneedles.

Abstract: Dispensable formulations, microneedles, microarray patches (MAPs), and systems that can facilitate simple, substantially pain-free, and consistent delivery of a wide range of active pharmaceutical ingredients (APIs) and doses, as well as methods of manufacturing and using the same are described herein.

Abstract: A MAP and applicator system can include a MAP and an applicator. The MAP can include a backing and a plurality of microneedles extending from the backing. The microneedles can include tips with a GLP-1 agonist; and a water-soluble base configured to at least partially dissolve upon contact with a bodily fluid of a subject causing the tip to be released below the skin. The applicator is configured to maintain the MAP; in response to an activation mechanism being activated, release a piston downward into the MAP; and push, via the piston, the MAP downward onto the skin surface of the subject such that the plurality of microneedles penetrate the skin surface and are delivered. Apexes of the microneedles are delivered to the subject at a depth of at least about 600 ?m and at least about 70% of the GLP-1 is delivered after release of tips of the microneedles.

Abstract: Dispensable formulations, microneedles, microarray patches (MAPs), and systems that can facilitate simple, substantially pain-free, and consistent delivery of a wide range of active pharmaceutical ingredients (APIs) and doses, as well as methods of manufacturing and using the same are described herein.

Abstract: Patch applicator devices are provided. The devices can include a reusable or single-use system for applying a push-through or breakaway patch to a patient's skin. The devices can improve application and effectiveness of microneedle based patches.

Abstract: Dispensable formulations, microneedles, microarray patches (MAPs), and systems that can facilitate simple, substantially pain-free, and consistent delivery of a wide range of active pharmaceutical ingredients (APIs) and doses, as well as methods of manufacturing and using the same are described herein.

Abstract: Patch applicator devices are provided. The devices can include a reusable or single-use system for applying a push-through or breakaway patch to a patient's skin. The devices can improve application and effectiveness of microneedle based patches.

Abstract: Microneedle and microneedle devices including implantable tips (e.g., silk-based tips) for sustained dermal delivery of a coronavirus and/or influenza vaccine, kits, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for controlled- or sustained-administration of a coronavirus vaccine and/or an influenza vaccine to provide improved immunogenicity and/or broad-spectrum immunity to a subject are also described.

Abstract: Microneedle and microneedle devices including, e.g., silk fibroin-based microneedles tips for sustained dermal delivery of an anti-cancer agent and/or an immunomodulatory agent, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for burst-release or sustained-release administration of an anti-cancer agent and/or an immunomodulatory agent to provide an improved immune response to a cancer in a subject are described.

Abstract: Fluidic devices and methods are provided.

Abstract: The present invention generally relates to the collection, storage, and stabilization of biological samples (e.g., bodily fluids, such as whole blood, blood serum, and blood plasma), and analytes thereof. More particularly, the present invention relates to polymer-based biological sample collection devices, and methods of making and using the same.

Abstract: Microneedle and microneedle devices including implantable silk-based tips for sustained dermal delivery of a vaccine, kits, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for controlled- or sustained-administration of a vaccine (e.g., an influenza vaccine) to provide improved immunogenicity and/or broad-spectrum immunity to a subject are also described.

Abstract: Articles and methods for collecting and/or facilitating transfer of fluids are generally provided. In some embodiments, an article comprises a fluid collection region for introducing a fluid, such as a sample (e.g., blood sample) or a reagent, into a fluidic system. The articles and methods described herein may be useful for facilitating the filling of relatively small channels with a fluid, such as channels of a microfluidic device. The articles and methods may, for example, interface with a patient sample (e.g., a droplet of blood), or with a macroscopic fluid source such as a pipette or syringe. In certain embodiments, articles and methods described herein may increase the ease of collecting a fluidic sample from a patient, prevent or reduce spillage of the fluidic sample, reduce contamination of a fluidic sample, and/or prevent or reduce air from entering a fluidic sample or device compared to certain existing fluid collection devices.

Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may comprise an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In some embodiments, fluidic devices for performing a vitamin D assay are provided.

Abstract: Articles and methods for collecting and/or facilitating transfer of fluids are generally provided. In some embodiments, an article comprises a fluid collection region for introducing a fluid, such as a sample (e.g., blood sample) or a reagent, into a fluidic system. The articles and methods described herein may be useful for facilitating the filling of relatively small channels with a fluid, such as channels of a microfluidic device. The articles and methods may, for example, interface with a patient sample (e.g., a droplet of blood), or with a macroscopic fluid source such as a pipette or syringe. In certain embodiments, articles and methods described herein may increase the ease of collecting a fluidic sample from a patient, prevent or reduce spillage of the fluidic sample, reduce contamination of a fluidic sample, and/or prevent or reduce air from entering a fluidic sample or device compared to certain existing fluid collection devices.

Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.

Abstract: Fluidic devices and methods are provided.

Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may include an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In certain embodiments, the detection channel may be used to provide feedback on the extent of incubation and/or mixing. Based on the feedback, one or more component of the fluidic system may be regulated to allow the requisite degree of mixing and/or incubation to be achieved.