Abstract: In various aspects and embodiments, the present invention provides hemostatic products and methods for treating wounds, including cavity wounds and non-compressible hemorrhage. In various embodiments, the invention employs hydrophobically-modified polymer foams, gels, or pastes.

Abstract: Methods, systems and software products for video editing systems are disclosed herein. The software product includes a computer readable medium storing instructions which, when executed by a processors, cause the processor to display a graphical user interface for a video editing system, the graphical user interface including first and second spaced apart timelines, and responsive to detecting a user interaction with one of the timelines, apply a corresponding interaction to the other timeline.

Abstract: A video editing system includes an import manager for importing media files into the video editing system; a user interface; and a synchronization engine for detecting imported media files having one or more common attributes and causing a display in the user interface of an indicia for each detected media file.

Abstract: A software product includes a non-transitory computer readable medium storing instructions which, when executed by a processor, cause the processor to display a graphical user interface for a video editing system, the user interface including a media bin displaying one or more media elements imported into the video editing system; a viewing window for viewing a selected one of the media elements; a timeline; and a concatenator element; and responsive to a user actuating the concatenator element, concatenates the media elements present in the media bin together into a single media element and loads the single media element into the viewing window.

Abstract: Disclosed herein is a polymer composition comprising an effective amount of a hydrophobically-modified polymer having functional groups along the backbone occupied by a fatty anhydride moiety. The polymer composition has a potent hemostatic action by gelling blood upon contact, and is suitable for treating internal and external bleeds. As disclosed herein, the modified polymer can be generated without the use of toxic reagents that would require removal from the product. Further, compositions are shelf stable even in a flowable form. That is, the hydrophobic grafts are not lost under product storage conditions (e.g., room temperature storage).

Abstract: Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: In part, the invention provides a new combination comprising (1) a GLP-1R agonist and (2) an ACC inhibitor or a DGAT2 inhibitor, or a KHK inhibitor or FXR agonist. The invention further provides new methods for treating diseases and disorders, for example, fatty liver, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, nonalcoholic steatohepatitis with liver fibrosis, nonalcoholic steatohepotitis with cirrhosis, and nonalcoholic steatohepatitis with cirrhosis and with hepatocellular carcinoma or with a metabolic-related disease, obesity, and type 2 diabetes, for example, using the new combination described herein.

Abstract: The present invention relates to a video editing system including: an import manager for importing media files into the video editing system; a user interface; and a synchronisation engine for detecting imported media files having one or more common attributes and causing the display in the user interface of an indicia for each detected media file.

Abstract: A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.

Abstract: Methods, systems and software products for video editing systems are disclosed herein. The software product includes a computer readable medium storing instructions which, when executed by a processors, cause the processor to display a graphical user interface for a video editing system, the graphical user interface including first and second spaced apart timelines, and responsive to detecting a user interaction with one of the timelines, apply a corresponding interaction to the other timeline.

Abstract: A software product includes a non-transitory computer readable medium storing instructions which, when executed by a processor, cause the processor to display a graphical user interface for a video editing system, the user interface including a media bin displaying one or more media elements imported into the video editing system; a viewing window for viewing a selected one of the media elements; a timeline; and a concatenator element; and responsive to a user actuating the concatenator element, concatenates the media elements present in the media bin together into a single media element and loads the single media element into the viewing window.

Abstract: A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.

Abstract: Disclosed herein is a polymer composition comprising an effective amount of a hydrophobically-modified polymer having functional groups along the backbone occupied by a fatty anhydride moiety. The polymer composition has a potent hemostatic action by gelling blood upon contact, and is suitable for treating internal and external bleeds. As disclosed herein, the modified polymer can be generated without the use of toxic reagents that would require removal from the product. Further, compositions are shelf stable even in a flowable form. That is, the hydrophobic grafts are not lost under product storage conditions (e.g., room temperature storage).

Abstract: A device for manipulating the temperature of a surface may include a heat transfer surface including active portions and a passive portion. The passive portion may include an inner passive portion disposed between each of the active portions and/or may include an outer passive portion that may surround each of the active portions. The active portions may form 40-90% of a total surface area of the heat transfer surface, where total surface area includes active portions and an inner passive portion. The passive portion(s) may have a thermal conductivity less than the active portion. A processor may be in electrical communication with thermoelectric modules defining or forming the active portions to generate a heat flux through the heat transfer surface. The heat flux through the active portions may be between 500 and 15,000 W/m2 during nominal operation of the device.

Abstract: Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic nature of the putty is tunable by the composition and enables the putty to conform to a variety of wound topographies. Likewise, a hemostatic polymer, for example chitosan or hydrophobically modified chitosan, is included in this matrix to impart hemostatic properties and tissue adhesive on the putty. The hemostatic polymers disclosed prevent microbial infection and are suitable for oxygen transfer required during normal wound metabolism.