Abstract: Disclosed herein are methods of treating a patient in need of therapy for prostate cancer comprising delivering a ?-radiation-emitting composition into the prostatic vasculature. In some embodiments, an absorbed dose of 60 Gy to 200 Gy is delivered to the prostate. In some embodiments, the ?-radiation-emitting composition is delivered into the arterial vasculature of the prostate via a catheter. In some embodiments, the ?-radiation-emitting composition comprises a suspension of the ?-radiation-emitting particles in an aqueous liquid.

Abstract: The present disclosure relates to, inter alia, improved methods for the treatment of solid tumors using embolic polymer microspheres, to embolic polymer microspheres that comprise a polymer and an inhibitor of the enzyme poly ADP ribose polymerase (PARP inhibitor) wherein the PARP inhibitor is held within the polymer microsphere and is elutable from the microsphere in aqueous media, and to methods of loading embolic polymer microspheres.

Abstract: The present invention relates to hydrogels comprising 1,2-diol or 1,3-diol groups acetalised with a radiopaque species of one or more covalently bound radiopaque halogens which are imageable during embolization therapy. The invention further relates to methods of making radiopaque polymers and radiopaque hydrogel microspheres to provide an imageable drug delivery system.

Abstract: Cyclized peptide compounds containing the NGR motif of formula (I) or a pharmaceutically-acceptable salt thereof are disclosed. Compositions comprising the cyclized peptide compounds and methods of their use are also disclosed.

Abstract: Cyclized peptide compounds containing the NGR motif of formula (I) or a pharmaceutically-acceptable salt thereof are disclosed. Compositions comprising the cyclized peptide compounds and methods of their use are also disclosed.

Abstract: A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.