Patents by Inventor Matthew Ernest Piccini

Matthew Ernest Piccini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid
    Patent number: 10590477
    Abstract: Embodiments of the present invention are directed toward devices, systems, and methods for purifying nucleic acids to conduct polymerase chain reaction (PCR) assays. In one example, a method includes generating complexes of silica beads and nucleic acids in a lysis buffer, transporting the complexes through an immiscible fluid to remove interfering compounds from the complexes, further transporting the complexes into a density medium containing components required for PCR where the nucleic acids disassociate from the silica beads, and thermocycling the contents of the density medium to achieve PCR. Signal may be detected from labeling agents in the components required for PCR.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: March 17, 2020
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Chung-Yan Koh, Yooli Kim Light, Matthew Ernest Piccini, Anup K. Singh
  • METHOD AND APPARATUS FOR PURIFYING NUCLEIC ACIDS AND PERFORMING POLYMERASE CHAIN REACTION ASSAYS USING AN IMMISCIBLE FLUID
    Publication number: 20180037932
    Abstract: Embodiments of the present invention are directed toward devices, systems, and methods for purifying nucleic acids to conduct polymerase chain reaction (PCR) assays. In one example, a method includes generating complexes of silica beads and nucleic acids in a lysis buffer, transporting the complexes through an immiscible fluid to remove interfering compounds from the complexes, further transporting the complexes into a density medium containing components required for PCR where the nucleic acids disassociate from the silica beads, and thermocycling the contents of the density medium to achieve PCR. Signal may be detected from labeling agents in the components required for PCR.
    Type: Application
    Filed: September 27, 2017
    Publication date: February 8, 2018
    Inventors: Chung-Yan Koh, Yooli Kim Light, Matthew Ernest Piccini, Anup K. Singh
  • Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid
    Patent number: 9803238
    Abstract: Embodiments of the present invention are directed toward devices, systems, and methods for purifying nucleic acids to conduct polymerase chain reaction (PCR) assays. In one example, a method includes generating complexes of silica beads and nucleic acids in a lysis buffer, transporting the complexes through an immiscible fluid to remove interfering compounds from the complexes, further transporting the complexes into a density medium containing components required for PCR where the nucleic acids disassociate from the silica beads, and thermocycling the contents of the density medium to achieve PCR. Signal may be detected from labeling agents in the components required for PCR.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: October 31, 2017
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Chung-Yan Koh, Yooli Kim Light, Matthew Ernest Piccini, Anup K. Singh