Patents by Inventor Matthew F. Brown

Matthew F. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monobactams
    Publication number: 20150148326
    Abstract: The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 28, 2015
    Inventors: Matthew F. Brown, Mark J. Mitton-Fry, Seungil Han, Manjinder Lall, Mark Plummer, Hud Lawrence Risley, Veerabahu Shanmugasundaram, Jeremy Starr
  • Hydroxamic acid derivatives useful as antibacterial agents
    Patent number: 8722686
    Abstract: The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II); and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B. L1-L4 A, B, R1-R4 and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: May 13, 2014
    Assignee: Pfizer Inc.
    Inventors: Matthew F. Brown, Charles F. Donovan, Edmund L. Ellsworth, Denton W. Hoyer, Timothy A. Johnson, Manjinder S. Lall, Chris Lim-Berakis, Sean T. Murphy, Debra A. Sherry, Clarke B. Taylor, Joseph S. Warmus
  • Fluoro-pyridinone derivatives useful as antibacterial agents
    Patent number: 8624034
    Abstract: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: January 7, 2014
    Assignee: Pfizer Inc.
    Inventors: Usa Reilly, Michael Melnick, Matthew F. Brown, Mark S. Plummer, Justin Montgomery, Ye Che, Loren Price
  • Monobactams
    Publication number: 20130252935
    Abstract: The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.
    Type: Application
    Filed: February 27, 2013
    Publication date: September 26, 2013
    Applicant: PFIZER INC.
    Inventors: Matthew F. Brown, Mark J. Mitton-Fry, Seungil Han, Manjinder Lall, Mark Plummer, Hud Lawrence Risley, Veerabahu Shanmugasundaram, Jeremy Starr
  • MONOBACTAMS
    Publication number: 20120302542
    Abstract: The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.
    Type: Application
    Filed: November 29, 2011
    Publication date: November 29, 2012
    Inventors: Matthew F. Brown, Mark J. Mitton-Fry, Seungil Han, Manjinder Lall, Mark Plummer, Hud Lawrence Risley, Veerabahu Shanmugasundaram, Jeremy Starr
  • FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
    Publication number: 20120232083
    Abstract: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
    Type: Application
    Filed: March 7, 2012
    Publication date: September 13, 2012
    Inventors: Usa REILLY, Michael MELNICK, Matthew F. BROWN, Mark S. PLUMMER, Justin MONTGOMERY, Ye CHE, Loren PRICE
  • Hydroxamic Acid Derivatives Useful as Antibacterial Agents
    Publication number: 20110178042
    Abstract: The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II); and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B. L1-L4 A, B, R1-R4 and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.
    Type: Application
    Filed: September 1, 2009
    Publication date: July 21, 2011
    Applicant: Pfizer Inc.
    Inventors: Matthew F. Brown, Charles F. Donovan, Edmund L. Eilsworth, Denton W. Hoyer, Timothy A. Johnson, Manjinder S. Lall, Chris Lim-Berakis, Sean T. Murphy, Debra A. Sherry, Clarke B. Taylor, Joseph S. Warmus
  • CYCLOALKYLAMINO ACID DERIVATIVES
    Publication number: 20100234435
    Abstract: The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: May 13, 2010
    Publication date: September 16, 2010
    Inventors: Samit K. Bhattacharya, Matthew F. Brown, Peter H. Dorff, Susan D. LaGreca, John W. Mickelson, Joseph A. Cornicelli, David L. Brown, Jennings Rex, John K. Walker, Rita Huff, Joseph W. Strohbach, Robert J. Maguire
  • Pyrrolo[2,3-d]pyrimidine compounds
    Patent number: 7687507
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: March 30, 2010
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Todd A. Blumenkopf, Mark E. Flanagan, Matthew F. Brown
  • CYCLOALKYLAMINO ACID DERIVATIVES
    Publication number: 20090227641
    Abstract: The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: November 7, 2008
    Publication date: September 10, 2009
    Inventors: Samit K. Bhattacharya, Matthew F. Brown, Peter H. Dorff, Susan D. LaGreca, John W. Mickelson, Joseph A. Cornicelli, David L. Brown, Rex Jennings, John K. Walker, Rita Huff, Joseph W. Strohbach, Robert J. Maguire
  • Pyrrolo[2,3-d]pyrimidine compounds
    Patent number: 7569569
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type 1 diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: August 4, 2009
    Assignee: Pfizer Inc.
    Inventors: Todd A. Blumenkopf, Mark E. Flanagan, Matthew F. Brown, Paul S. Changelian
  • Piperazine derivatives
    Patent number: 7098212
    Abstract: The present invention relates to compounds of the formula I and the pharmaceutically acceptable forms thereof; wherein X, Y, a, b, c, d, R1, R2, R3, R4 and R5 are as defined herein. Moreover, the present invention is also directed at pharmaceutical compositions comprising a compound of the formula I and a pharmaceutically acceptable carrier. Furthermore, the present invention is directed at methods of using the herein described compounds and compositions for treating or preventing a disorder or condition that can be treated or prevented by antagonizing the CCR1 receptor in a mammal.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: August 29, 2006
    Inventors: Laura C. Blumberg, Matthew F. Brown, Matthew M. Hayward, Gregory D. Lundquist, Christopher S. Poss, Andrei Shavnya
  • Pyrrolo [2,3-D] pyrimidine compounds
    Patent number: 6890929
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: May 10, 2005
    Assignee: Pfizer, Inc.
    Inventors: Todd A. Blumenkopf, Mark E. Flanagan, Matthew F. Brown, Paul S. Changelian
  • Novel phosphorus-containing derivatives
    Publication number: 20040127465
    Abstract: A compound of the Formula I 1
    Type: Application
    Filed: December 12, 2003
    Publication date: July 1, 2004
    Applicant: Pfizer Inc
    Inventors: Matthew F. Brown, Matthew M. Hayward
  • Methods of using sulfonic acid derivatives
    Publication number: 20040116441
    Abstract: The present invention relates to methods of using CCR1 antagonists as immunomodulatory agents.
    Type: Application
    Filed: October 16, 2003
    Publication date: June 17, 2004
    Applicant: Pfizer Inc
    Inventors: Matthew F. Brown, Anderson S. Gaweco, Ronald P. Gladue, Matthew M. Hayward
  • Heteroaryl-hexanoic acid amide derivatives as immonomodulatory agents
    Publication number: 20040097554
    Abstract: The present invention relates to compounds of the formula (I) 1
    Type: Application
    Filed: October 16, 2003
    Publication date: May 20, 2004
    Applicant: Pfizer Inc
    Inventors: Matthew F. Brown, Anderson S. Gaweco, Ronald P. Gladue, John C. Kath, Christopher S. Poss
  • Methods of using piperazine derivatives
    Publication number: 20040092529
    Abstract: The present invention relates to compounds of the formula I 1
    Type: Application
    Filed: October 16, 2003
    Publication date: May 13, 2004
    Applicant: Pfizer Inc
    Inventors: Laura C. Blumberg, Matthew F. Brown, Anderson S. Gaweco, Ronald P. Gladue, Matthew M. Hayward, Gregory D. Lundquist, Christopher S. Poss, Andrei Shavnya
  • Methods of using CCR1 antagonists as immunomodulatory agents
    Publication number: 20040087571
    Abstract: The present invention relates to methods of using CCR1 antagonists as immunomodulatory agents.
    Type: Application
    Filed: October 16, 2003
    Publication date: May 6, 2004
    Applicant: Pfizer Inc
    Inventors: Matthew F. Brown, Anderson S. Gaweco, Ronald P. Gladue, John C. Kath, Christopher S. Poss
  • Novel piperidine derivatives
    Publication number: 20040063688
    Abstract: A compound of the formula 1
    Type: Application
    Filed: July 8, 2003
    Publication date: April 1, 2004
    Applicant: Pfizer Inc.
    Inventors: Laura C. Blumberg, Matthew F. Brown, Matthew M. Hayward, Christopher S. Poss
  • Novel piperidine derivatives
    Publication number: 20040063759
    Abstract: A compound of the formula 1
    Type: Application
    Filed: July 8, 2003
    Publication date: April 1, 2004
    Applicant: Pfizer Inc.
    Inventors: Laura C. Blumberg, Matthew F. Brown, Matthew M. Hayward, Christopher S. Poss