Abstract: Embodiments of the invention provide systems and methods for testing acoustic systems. According to one embodiment, a method for testing an acoustic system can comprise receiving a signal from the acoustic system at a testing device coupled with the acoustic system via one of a plurality of channels between the acoustic system and the testing device. The signal can include a pattern of pulses including Doppler pulses. At least one Doppler pulse from the pattern pulses of the signal can be detected with the testing device. A response to the signal from the acoustic system can be provided by generating an echo pulse with the testing device based on the detected at least one Doppler pulse wherein the echo pulse is frequency shifted from the detected at least one Doppler pulse and mimics a response to the detected at least one Doppler pulse for a selected acoustic probe.

Abstract: Embodiments of the invention provide for testing acoustic systems. According to one embodiment, testing an acoustic system can comprise receiving a signal from the acoustic system at a testing device via one of a plurality of channels between the acoustic system and the testing device. At least one pulse from a pattern pulses of the signal can be detected with the testing device by matching the pattern of pulses to an expected pulse pattern for the acoustic system. For example, matching the pattern of pulses to an expected pulse pattern can comprise determining whether the pulse pattern includes a first pulse type. If the pulse pattern includes the first pulse type, a determination can be made whether the pulse pattern further includes a second pulse type. If the pulse pattern further includes the second pulse type, a subsequent pulse of the second pulse type can be identified and detected.

Abstract: Embodiments of the invention provide systems and methods for testing acoustic systems. According to one embodiment, a method for testing an acoustic system can comprise receiving a signal from the acoustic system at a testing device coupled with the acoustic system via one of a plurality of channels between the acoustic system and the testing device. The signal can include a pattern of pulses. At least one pulse from the pattern of pulses of the signal can be detected with the testing device. A response to the signal from the acoustic system can be provided by generating an echo pulse with the testing device based on the detected at least one pulse. The echo pulse can mimic a response to the detected at least one pulse for a selected acoustic probe.

Abstract: Embodiments of the invention provide systems and methods for testing acoustic systems. According to one embodiment, a method for testing an acoustic system can comprise receiving a signal from the acoustic system at a testing device coupled with the acoustic system via one of a plurality of channels between the acoustic system and the testing device. The signal can include a pattern of pulses. At least one pulse from the pattern of pulses of the signal can be detected with the testing device. A response to the signal from the acoustic system can be provided by generating an echo pulse with the testing device based on the detected at least one pulse. The echo pulse can mimic a response to the detected at least one pulse for a selected acoustic probe.

Abstract: Embodiments of the invention provide for testing acoustic systems. According to one embodiment, testing an acoustic system can comprise receiving a signal from the acoustic system at a testing device via one of a plurality of channels between the acoustic system and the testing device. At least one pulse from a pattern pulses of the signal can be detected with the testing device by matching the pattern of pulses to an expected pulse pattern for the acoustic system. For example, matching the pattern of pulses to an expected pulse pattern can comprise determining whether the pulse pattern includes a first pulse type. If the pulse pattern includes the first pulse type, a determination can be made whether the pulse pattern further includes a second pulse type. If the pulse pattern further includes the second pulse type, a subsequent pulse of the second pulse type can be identified and detected.

Abstract: Embodiments of the invention provide systems and methods for testing acoustic systems. According to one embodiment, a method for testing an acoustic system can comprise receiving a signal from the acoustic system at a testing device coupled with the acoustic system via one of a plurality of channels between the acoustic system and the testing device. The signal can include a pattern of pulses including Doppler pulses. At least one Doppler pulse from the pattern pulses of the signal can be detected with the testing device. A response to the signal from the acoustic system can be provided by generating an echo pulse with the testing device based on the detected at least one Doppler pulse wherein the echo pulse is frequency shifted from the detected at least one Doppler pulse and mimics a response to the detected at least one Doppler pulse for a selected acoustic probe.

Abstract: The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.

Abstract: The present invention provides nucleic acid molecules, polypeptides, antibodies and methods for the diagnosis and/or treatment of psoriasis.

Abstract: This invention provides certain crystallized, protein kinase-ligand complexes, in particular P38-ligand complexes, and their structure coordinates. The structure coordinates are based on the structure of a phosphorylated P38&ggr; complex which has now been solved and which reveals new structural information useful for understanding the activated states of other, related kinase proteins as described herein. The key structural features of the proteins, particularly the shape of the substrate binding site, are useful in methods for designing or identifying selective inhibitors of the protein kinases, particularly P38&ggr; and in solving the structures of other proteins with similar features. The structure coordinates may be encoded in a data storage medium for use with a computer for graphical three-dimensional representation of the structure and for computer-aided molecular design of new inhibitors.

Abstract: This invention provides certain crystallized, protein kinase-ligand complexes, in particular P38-ligand complexes, and their structure coordinates. The structure coordinates are based on the structure of a phosphorylated P38&ggr; complex which has now been solved and which reveals new structural information useful for understanding the activated states of other, related kinase proteins as described herein. The key structural features of the proteins, particularly the shape of the substrate binding site, are useful in methods for designing or identifying selective inhibitors of the protein kinases, particularly P38&ggr; and in solving the structures of other proteins with similar features. The structure coordinates may be encoded in a data storage medium for use with a computer for graphical three-dimensional representation of the structure and for computer-aided molecular design of new inhibitors.