Patents by Inventor Matthew G. Beaver

Matthew G. Beaver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesizing apremilast
    Patent number: 12351555
    Abstract: Provided herein are processes for synthesizing apremilast comprising reacting 3-acetamidophthalic anhydride and (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine or a salt thereof to form apremilast. Also provided are processes for isolating apremilast from the reaction mixture, as described herein.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: July 8, 2025
    Assignee: AMGEN INC.
    Inventors: Matthew G. Beaver, Carolyn Cohen, Neil Fred Langille, Simone Spada
  • SYNTHESIS OF KRAS G12C INHIBITOR COMPOUND
    Publication number: 20250179068
    Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2,2?,2?-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-fluorophenol), useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
    Type: Application
    Filed: December 19, 2024
    Publication date: June 5, 2025
    Applicant: AMGEN INC.
    Inventors: Andrew T. PARSONS, Matthew G. BEAVER
  • PROCESS FOR RACEMIZING AND ISOLATING ATROPISOMERS OF 7-CHLORO-6-FLUORO-1-(2-ISOPROPYL-4-METHYLPYRIDIN-3-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE
    Publication number: 20250122197
    Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.
    Type: Application
    Filed: December 19, 2024
    Publication date: April 17, 2025
    Applicant: AMGEN INC.
    Inventors: Matthew G. BEAVER, Michael T. CORBETT, Yuanqing FANG, David D. FORD, Andrew T. PARSONS, Gabrielle ST-PIERRE, Reem TELMESANI
  • PROCESS FOR RACEMIZING AND ISOLATING ATROPISOMERS OF 7-CHLORO-6-FLUORO-1-(2-ISOPROPYL-4-METHYLPYRIDIN-3-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE
    Publication number: 20230391771
    Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.
    Type: Application
    Filed: October 6, 2021
    Publication date: December 7, 2023
    Applicant: AMGEN INC.
    Inventors: Matthew G. BEAVER, Michael T. CORBETT, Yuanqing FANG, David D. FORD, Andrew T. PARSONS, Gabrielle ST-PIERRE, Reem TELMESANI
  • DIOL DESYMMETRIZATION BY NUCLEOPHILIC AROMATIC SUBSTITUTION
    Publication number: 20230365588
    Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound Y that can be used to prepare them where the variable R1 is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof, compound A2, and salts and solvates thereof, and compound A3 and salts and solvates thereof.
    Type: Application
    Filed: September 1, 2021
    Publication date: November 16, 2023
    Applicant: AMGEN INC.
    Inventors: MATTHEW G. BEAVER, JOSEPH MICHAEL DENNIS, PETER DORNAN, STEVEN MENNEN, JASON S. TEDROW, NEIL F. LANGILLE, CAROLYN MICHELLE COHEN, ANDREAS RENE ROTHELI
  • Ring Closing Synthesis of Macrocyclic MCL-1 Inhibitor Intermediates
    Publication number: 20230167130
    Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
    Type: Application
    Filed: May 5, 2021
    Publication date: June 1, 2023
    Applicant: AMGEN INC.
    Inventors: Austin G. SMITH, Jason S. TEDROW, Gabrielle ST-PIERRE, Oliver Ralf THIEL, Liang HUANG, Philipp C. ROOSEN, John T. COLYER, Kyle D. BAUCOM, Ari ERICSON, Matthew G. BEAVER, Rahul P. SANGODKAR, Michael A. LOVETTE, Robert Ronald MILBURN, Alan H. CHERNEY, Sheng CUI
  • PROCESS FOR SYNTHESIZING APREMILAST
    Publication number: 20220348542
    Abstract: Provided herein are processes for synthesizing apremilast comprising reacting 3-acetamidophthalic anhydride and (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine or a salt thereof to form apremilast. Also provided are processes for isolating apremilast from the reaction mixture, as described herein.
    Type: Application
    Filed: April 25, 2022
    Publication date: November 3, 2022
    Inventors: Matthew G. Beaver, Carolyn Cohen, Neil Fred Langille, Simone Spada