Abstract: A dual nuclear MR transmission line resonator is capable of operating on 1X pairs, with X being 31P, 23Na, 3He, or 129Xe. The resonator avoids many of the problems inherent in conventional dual nuclear designs. No LC trap is used, and the coil has substantially the same spatial profile on both nuclei. In the resonator, an augmented MR tune/match circuit, includes a conventional capacitive L circuit, with the L circuit shunted at a match point by a notch filter tuned to a frequency of a companion nucleus. Also disclosed is a method for simultaneously resonating conductive loops of surface coils or conductive elements of volume coils simultaneously on both 1H and X with hybrid transmission line termination elements bonded to the resonator loop or conductive elements in shunt with respect to one another.

Abstract: A dual nuclear MR transmission line resonator is capable of operating on 1X pairs, with X being 31P, 23Na, 3He, or 129Xe. The resonator avoids many of the problems inherent in conventional dual nuclear designs. No LC trap is used, and the coil has substantially the same spatial profile on both nuclei. In the resonator, an augmented MR tune/match circuit, includes a conventional capacitive L circuit, with the L circuit shunted at a match point by a notch filter tuned to a frequency of a companion nucleus. Also disclosed is a method for simultaneously resonating conductive loops of surface coils or conductive elements of volume coils simultaneously on both 1H and X with hybrid transmission line termination elements bonded to the resonator loop or conductive elements in shunt with respect to one another.

Abstract: An RF coil assembly for an MRI system includes a resonator formed by a cylindrical shield and pairs of opposing conductive legs disposed symmetrically around a central axis and extending the axial length of the shield. Drive circuitry for each pair of opposing conductive legs includes a current balun that maintains substantially equal and opposite currents in the two conductive legs. Terminal susceptance elements are used to maintain maximum currents and minimum voltage at the midpoints of the conductive legs. Multinuclear measurements can be made simultaneously at different Larmor frequencies.

Abstract: An RF coil assembly for an MRI system includes a resonator formed by a cylindrical shield and pairs of opposing conductive legs disposed symmetrically around a central axis and extending the axial length of the shield. One set of conductive leg pairs is tuned to operate at the Larmor frequency of 13C and another set is tuned to operate at the Larmor frequency of 1H. Drive circuitry operates the RF coil assembly to produce 1H spin magnetization which is transferred to 13C magnetization by the nuclear overhauser effect and to acquire MR data from the 13C spins. Multinuclear measurements can be made simultaneously at different Larmor frequencies.

Abstract: An RF coil assembly for an MRI system includes a resonator formed by a cylindrical shield and pairs of opposing conductive legs disposed symmetrically around a central axis and extending the axial length of the shield. One set of conductive leg pairs is tuned to operate at the Larmor frequency of 13C and another set is tuned to operate at the Larmor frequency of 1H. Drive circuitry operates the RF coil assembly to produce 1H spin magnetization which is transferred to 13C magnetization by the nuclear overhauser effect and to acquire MR data from the 13C spins. Multinuclear measurements can be made simultaneously at different Larmor frequencies.

Abstract: Disclosed are methods for making surface plasmon resonance-capable arrays wherein molecules, such as proteins or nucleic acids, or cells, are adhered to a metal substrate. The metal substrates are modified by depositing an ?-modified alkanethiol monolayer to the substrate and then contacting the ?-modified monolayer with a heterobifunctional linking compound. Biomolecules or cells can then be attached to the heterobifunctional linking compound. Also disclosed are arrays wherein glutathione-containing molecules are immobilized on the substrate and GST-containing molecules are then specifically immobilized onto the substrate, taking advantage of the affinity between glutathione and GST.

Abstract: Disclosed are methods for making surface plasmon resonance-capable arrays wherein molecules, such as proteins or nucleic acids, or cells, are adhered to a metal substrate. The metal substrates are modified by depositing an &ohgr;-modified alkanethiol monolayer to the substrate and then contacting the &ohgr;-modified monolayer with a heterobifunctional linking compound. Biomolecules or cells can then be attached to the heterobifunctional linking compound. Also disclosed are arrays wherein glutathione-containing molecules are immobilized on the substrate and GST-containing molecules are then specifically immobilized onto the substrate, taking advantage of the affinity between glutathione and GST.