Abstract: The present disclosure relates generally to methods of using modulators of COT (cancer Osaka thyroid) for treating, stabilizing, or lessening the severity or progression of liver disease, in particular, Nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).

Abstract: A safety razor includes an elongated handle having an open end, a cartridge head having adjacent angled sections, and first and second blade sets arranged facing away from each other on the adjacent angled sections. The first and second blade sets are orientated generally in parallel with a longitudinal axis of the elongated handle, and the cartridge head has a generally V-shape. The cartridge head is releasable secured to the open end of the elongated handle. In addition, an elastic flexure bearing extends along an apex between the angled sections and joins together the adjacent angled sections. The elastic flexure bearing is comprised of a type of material different than the adjacent angled sections of the cartridge head. The cartridge head includes a base having an upper surface and a lower surface, and a plurality of latching pins coupled to, and extending away from the lower surface of the base.

Abstract: A safety razor includes a handle assembly elongated along a longitudinal axis, a blade head assembly pivotably connected to the handle assembly and having a first blade set thereon, the first blade set extending generally in parallel with the longitudinal axis. The blade head assembly can be releasably connected to the handle assembly to facilitate replacement. The blade head assembly can include a second blade set, the second blade set extending generally in parallel with the longitudinal axis, the first and second blade sets arranged facing away from each other such that the shaving direction of the blade head assembly can be altered by rotating the safety razor about the longitudinal axis. The safety razor can further include a biasing element for resisting pivotal motion of the blade assembly about the longitudinal axis and a control mechanism operable to selectively limit the pivotal motion of the blade head assembly.

Abstract: A safety razor includes a handle assembly elongated along a longitudinal axis, a blade head assembly pivotably connected to the handle assembly and having a first blade set thereon, the first blade set extending generally in parallel with the longitudinal axis. The blade head assembly can be releasably connected to the handle assembly to facilitate replacement. The blade head assembly can include a second blade set, the second blade set extending generally in parallel with the longitudinal axis, the first and second blade sets arranged facing away from each other such that the shaving direction of the blade head assembly can be altered by rotating the safety razor about the longitudinal axis. The safety razor can further include a biasing element for resisting pivotal motion of the blade assembly about the longitudinal axis and a control mechanism operable to selectively limit the pivotal motion of the blade head assembly.

Abstract: A safety razor includes a handle assembly elongated along a longitudinal axis, a blade head assembly pivotably connected to the handle assembly and having a first blade set thereon, the first blade set extending generally in parallel with the longitudinal axis. The blade head assembly can be releasably connected to the handle assembly to facilitate replacement. The blade head assembly can include a second blade set, the second blade set extending generally in parallel with the longitudinal axis, the first and second blade sets arranged facing away from each other such that the shaving direction of the blade head assembly can be altered by rotating the safety razor about the longitudinal axis. The safety razor can further include a biasing element for resisting pivotal motion of the blade assembly about the longitudinal axis and a control mechanism operable to selectively limit the pivotal motion of the blade head assembly.

Abstract: A lazer rangefinder employs time-of-flight measurements for providing high resolution when measuring range and intensity in a system for accurately mapping and classifying agriculture foliage. Profiles and parameters of the foliage and trees are measured and calculated for classifying the tree, controlling mechanical devices for applying only a pre-selected amount of treatment materials to the tree, and estimating production yeilds. Using a global positioning receiver, a global location for the center of each tree, whether fully grown, juvenile, or dead is identified and used in mapping the measured trees.

Abstract: A self-adjusting contact mechanism is provided for a belt drive system which mechanism includes a contact shoe having a low friction surface in contact with the belt and a mechanism for biasing the low friction surface of the contact shoe against the belt with a controlled force profile which may be constant or may vary within a selected range over the permitted movement for the shoe. The shoe is preferably mounted to a lever arm through a pivot joint to permit the shoe to remain substantially parallel to the belt and in contact with the belt over the entire low friction surface of the shoe regardless of lever arm position. Force on the lever arm is provided by a compression mechanism which may include a pair of counterbalancing springs, with the spring biasing the lever arm toward the belt being stronger than the counterbalancing spring and preferably with the force for at least one of the springs being adjustable.

Abstract: A sorting and conveying system has a longitudinally extending conveyor having at least one tilt tray, but preferably a plurality, on the conveyor for diverting selected articles from the conveyor. There is at least one hanger for holding a plurality of bags. A chute extends between the tilt tray and the hanger. A flexible sheet diverter has an entrance near the top adjacent the chute and an exit near the bottom adjacent the bags, so that articles diverted from the conveyor will be delivered to the exit. Cylinders are provided for moving the sheet diverter so that the exit is positioned to deliver a selected article into a selected bag on the hanger. There are a plurality of tilt trays along the conveyor and a plurality of hangers so that a selected article on the conveyor may be delivered from a selected tilt tray to a selected bag. Mounts are provided for mounting the flexible sheet diverter for shaped movement, and there are air cylinders for moving the flexible sheet diverter.

Abstract: A sorting and conveying system has a longitudinally extending conveyor having at least one tilt tray, but preferably a plurality, on the conveyor for diverting selected articles from the conveyor. There is at least one hanger for holding a plurality of bags. A chute extends between the tilt tray and the hanger. A movable bowl diverter has an entrance opening near the top adjacent the chute and an exit opening near the bottom, so that articles diverted from the conveyor will be delivered to the exit opening. Means are provided for moving the bowl diverter so that the exit opening is positioned to deliver a selected article into a selected bag on said hanger. There are a plurality of tilt trays along the conveyor and a plurality of hangers so that a selected article on the conveyor may be delivered from a selected tilt tray to a selected bag. Means are provided for mounting the bowl diverter for rotational movement, and there is a drive for rotating the bowl diverter.

Abstract: A sorting and conveying system has a longitudinally extending conveyor having at least one tilt tray, but preferably a plurality, on the conveyor for diverting selected articles from the conveyor. There is at least one hanger for holding a plurality of bags. A chute extends between the tilt tray and the hanger. A movable bowl diverter has an entrance opening near the top adjacent the chute and an exit opening near the bottom, so that articles diverted from the conveyor will be delivered to the exit opening. Means are provided for moving the bowl diverter so that the exit opening is positioned to deliver a selected article into a selected bag on said hanger. There are a plurality of tilt trays along the conveyor and a plurality of hangers so that a selected article on the conveyor may be delivered from a selected tilt tray to a selected bag. Means are provided for mounting the bowl diverter for rotational movement, and there is a drive for rotating the bowl diverter.