Abstract: Some embodiments of the disclosure disclose manifolds, microfluidic systems and methods that provide control over fluid flow distribution to an array of bio-scaffolds contained within the manifolds. In some embodiments, multiple perfusates may be injected into the manifold via multiple inlets where the manifold contains a bio-assembly with a substrate having a bio-scaffold disposed thereon. Biological investigations of the perfusates may then be conducted in the vascular components and chambers of the bio-scaffold.

Abstract: A bio-assembly, a kit for a bio-assembly and methods of using the same are provided. The bio-assembly includes a substrate and a bio-scaffold affixed to the substrate. In accordance with various embodiments, a loader plate having a partition or a loader and a plate having a partition are provided. In accordance with various embodiments, the loader plate includes a partition outlet and a partition inlet, wherein the partition outlet and the partition inlet in fluid communication with the gel. In accordance with various embodiments, the partition comprising an internal volume and shaped to receive the bio-scaffold, and the loader includes a loader inlet and a loader outlet in fluid communication with the gel. In accordance with various embodiments, a bio-compatible adhesive positioned between the substrate and the loader plate or plate. In accordance with various embodiments, a fluid mixture is injected into the bio-scaffold.

Abstract: A massage therapy device having a roller and detachable thermal cover is disclosed. The roller has a series of unique ridges that optimize the application of therapeutic pressure to portions of a user's body. The thermal cover contains thermal retention material that can be heated or cooled. When the thermal cover is detachably connected to the roller, thermal therapy can be applied to muscle and other tissue in conjunction with the pressure therapy applied with the ridges of the roller. The configuration, temperature, and pressure application angle of the device can be varied to maximize the versatility of the device and provide individualized treatment.

Abstract: A massage therapy device having a roller and detachable thermal cover is disclosed. The roller has a series of unique ridges that optimize the application of therapeutic pressure to portions of a user's body. The thermal cover contains thermal retention material that can be heated or cooled. When the thermal cover is detachably connected to the roller, thermal therapy can be applied to muscle and other tissue in conjunction with the pressure therapy applied with the ridges of the roller. The configuration, temperature, and pressure application angle of the device can be varied to maximize the versatility of the device and provide individualized treatment.