Patents by Inventor Matthew Giese

Matthew Giese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LINKERS FOR IMPROVING THE STABILITY OF BIOCONJUGATES AND THE SELECTIVITY OF PAYLOAD RELEASE
    Publication number: 20230158169
    Abstract: Disclosed herein are linker architectures for conjugates that do not rely on the SAR of the cleavable trigger or the large steric bulk of a closely positioned antibody to alter payload release. These linkers are expected to reduce off-target payload release facilitated by extracellular cathepsins, and may also be applicable to conjugates of antibody fragments that lack the steric protection from a full antibody. In addition, the linkers disclosed herein are expected to provide more selective intracellular payload release. Thus, these linkers can function synergistically with the targeting vector to confer differential payload release rates in vivo that improve the selectivity of intracellular payload release and reduce off target toxicity.
    Type: Application
    Filed: September 23, 2022
    Publication date: May 25, 2023
    Inventors: Matthew GIESE, Paul DAVIS
  • Linkers for improving the stability of bioconjugates and the selectivity of payload release
    Patent number: 11510994
    Abstract: Disclosed herein are linker architectures for conjugates that do not rely on the SAR of the cleavable trigger or the large steric bulk of a closely positioned antibody to alter payload release. These linkers are expected to reduce off-target payload release facilitated by extracellular cathepsins, and may also be applicable to conjugates of antibody fragments that lack the steric protection from a full antibody. In addition, the linkers disclosed herein are expected to provide more selective intracellular payload release. Thus, these linkers can function synergistically with the targeting vector to confer differential payload release rates in vivo that improve the selectivity of intracellular payload release and reduce off target toxicity.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: November 29, 2022
    Assignee: EqIP, LLC
    Inventors: Matthew Giese, Paul D. Davis
  • LINKERS FOR IMPROVING THE STABILITY OF BIOCONJUGATES AND THE SELECTIVITY OF PAYLOAD RELEASE
    Publication number: 20220265848
    Abstract: Disclosed herein are linker architectures for conjugates that do not rely on the SAR of the cleavable trigger or the large steric bulk of a closely positioned antibody to alter payload release. These linkers are expected to reduce off-target payload release facilitated by extracellular cathepsins, and may also be applicable to conjugates of antibody fragments that lack the steric protection from a full antibody. In addition, the linkers disclosed herein are expected to provide more selective intracellular payload release. Thus, these linkers can function synergistically with the targeting vector to confer differential payload release rates in vivo that improve the selectivity of intracellular payload release and reduce off target toxicity.
    Type: Application
    Filed: December 17, 2021
    Publication date: August 25, 2022
    Inventors: Matthew GIESE, Paul D. DAVIS
  • Breeding, production, processing and use of specialty cannabis
    Patent number: 9095554
    Abstract: The invention provides compositions and methods for the breeding, production, processing and use of specialty cannabis.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: August 4, 2015
    Assignee: Biotech Institute LLC
    Inventors: Mark Anthony Lewis, Michael D Backes, Matthew Giese
  • BREEDING, PRODUCTION, PROCESSING AND USE OF SPECIALTY CANNABIS
    Publication number: 20140287068
    Abstract: The invention provides compositions and methods for the breeding, production, processing and use of specialty cannabis.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Applicant: Biotech Institute LLC
    Inventors: Mark Anthony LEWIS, Michael D. Backes, Matthew Giese
  • Hat
    Patent number: D749306
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: February 16, 2016
    Inventors: Todd W. Benz, Matthew Giese