Abstract: The present invention includes compounds of formula (I) and methods for its preparation and treatment of disorders with activated peroxisome preoliferator-activated receptor gamma (PPARG), particularly cancer.

Abstract: An electric snowmobile, has: a frame; a drive track assembly having a drive track and a sprocket; an electric motor mounted to the frame; and a transmission mounted to the frame, the transmission drivingly engaging the electric motor to the drive track, the transmission having an input drivingly engaged by the electric motor and an output drivingly engaging the sprocket, the transmission having a speed ratio defined as a rotational speed of the input to a rotational speed of the output, and wherein one or more of: a rotor-to-sprocket ratio ranging from 0.65 to 1.30, a rotor-to-transmission ratio ranging from 52 mm to 180 mm, a stator-to-sprocket ratio ranging from 0.20 to 0.58, and a rotor size-to-sprocket ratio ranging from 25 mm to 105 mm.

Abstract: An energy harvesting electronic primer (e-primer) system including smart ammunition with e-primer technology to enhance public safety from the discharge of a firearm by replacing conventional mechanical primers used for the activation of energetic materials with an electronic primer in center fire type ammunitions, grenades, bombs and other explosive devices wherein the ammunition includes an e-primer system having a firing pin, primer cup with a safety switch, antenna, piezo element, diode, capacitor, microcontroller, thermal wire, nanoenergetic and flash hole and radio transmitter circuitry wherein the mechanical force of the firing pin strikes a nanoenergetic material to activate the initial phase of an energetic train unless the e-primer is neutralized by a radio or acoustic signal captured by the antenna mounted within the ammunition where the radio signal includes a deactivation code to neutralize the ammunition. when located in a space specifically designed to receive the radio or acoustic signal.

Abstract: A method is disclosed of providing a graphical user interface (GUI) for simulating target detection and recognition. The method includes providing a user entry area for receiving user entered ground truth attributes defining one or more respective simulated physical objects, and providing a user entry area for receiving user entered collection attributes defining one or more collections, each collection being a simulation of automated target recognition applied to simulated sensor output associated with simulated sensing of the one or more simulated physical objects. The method further includes simulating detection of the one or more simulated physical objects and recognition based on the ground truth attributes and the collection attributes, generating detection data about at least one detected object based on the simulated target detection, and displaying the detection data.

Abstract: A simulator to simulate target detection and recognition is provided. The simulator includes a memory configured to store instructions and a processor disposed in communication with said memory. The processor upon execution of the instructions is configured to receive ground truth attributes defining one or more respective simulated physical objects and receive collection attributes defining one or more collections. Each collection is a simulation of automated target recognition applied to simulated sensor output associated with simulated sensing of the one or more simulated physical objects. The processor upon execution of the instructions is further configured to simulate detection of the one or more simulated physical objects and recognition based on the ground truth attributes and the collection attributes and output detection data about at least one detected object based on the simulation of target detection.

Abstract: A method to simulate target detection and recognition is provided. The method includes receiving ground truth attributes defining one or more respective simulated physical objects and receiving collection attributes defining one or more collections. Each collection is a simulation of automated target recognition applied to simulated sensor output associated with simulated sensing of the one or more simulated physical objects. The method further includes simulating detection of the one or more simulated physical objects and recognition based on the ground truth attributes and the collection attributes, generating detection data about at least one detected object based on the simulated target detection, and outputting the detection data.

Abstract: The generation of antigen specific T cells by controlled ex vivo induction or expansion can provide highly specific and beneficial T cell therapies. The present disclosure provides T cell manufacturing methods and therapeutic T cell compositions which can be used for treating subjects with cancer and other conditions, diseases and disorders personal antigen specific T cell therapy.

Abstract: The present invention relates to neoplasia vaccine or immunogenic composition administered in combination with other agents, such as checkpoint blockade inhibitors for the treatment or prevention of neoplasia in a subject

Abstract: The generation of antigen specific T cells by controlled ex vivo induction or expansion can provide highly specific and beneficial T cell therapies. The present disclosure provides T cell manufacturing methods and therapeutic T cell compositions which can be used for treating subjects with cancer and other conditions, diseases and disorders personal antigen specific T cell therapy.

Abstract: A subsystem of a tactical information system is provided that includes a memory configured to store instructions and a processor disposed in communication with the memory. The processor, upon execution of the instructions is configured to receive first standardized entity messages that include target information from multiple automatic target recognition (ATR) systems, parse the first standardized entity messages to extract the target information, provide the extracted target information to a fusion algorithm for fusion processing that determines whether to fuse the target information from different ATR systems and fuses the extracted target information to generate fused target information about a single target when determined to do so, receive fused target information about the single target, if any, from the fusion algorithm, and generate a second standardized entity message that includes the fused target information about the single target.

Abstract: A subsystem of a tactical information system is provided that includes a memory configured to store instructions and a processor disposed in communication with the memory. The processor, upon execution of the instructions is configured to receive first standardized entity messages that include target information from multiple automatic target recognition (ATR) systems, parse the first standardized entity messages to extract the target information, provide the extracted target information to a fusion algorithm for fusion processing that determines whether to fuse the target information from different ATR systems and fuses the extracted target information to generate fused target information about a single target when determined to do so, receive fused target information about the single target, if any, from the fusion algorithm, and generate a second standardized entity message that includes the fused target information about the single target.

Abstract: The generation of antigen specific T cells by controlled ex vivo induction or expansion can provide highly specific and beneficial T cell therapies. The present disclosure provides T cell manufacturing methods and therapeutic T cell compositions which can be used for treating subjects with cancer and other conditions, diseases and disorders personal antigen specific T cell therapy.

Abstract: A method to simulate target detection and recognition is provided. The method includes receiving ground truth attributes defining one or more respective simulated physical objects and receiving collection attributes defining one or more collections. Each collection is a simulation of automated target recognition applied to simulated sensor output associated with simulated sensing of the one or more simulated physical objects. The method further includes simulating detection of the one or more simulated physical objects and recognition based on the ground truth attributes and the collection attributes, generating detection data about at least one detected object based on the simulated target detection, and outputting the detection data.

Abstract: A simulator to simulate target detection and recognition is provided. The simulator includes a memory configured to store instructions and a processor disposed in communication with said memory. The processor upon execution of the instructions is configured to receive ground truth attributes defining one or more respective simulated physical objects and receive collection attributes defining one or more collections. Each collection is a simulation of automated target recognition applied to simulated sensor output associated with simulated sensing of the one or more simulated physical objects. The processor upon execution of the instructions is further configured to simulate detection of the one or more simulated physical objects and recognition based on the ground truth attributes and the collection attributes and output detection data about at least one detected object based on the simulation of target detection.

Abstract: A method is disclosed of providing a graphical user interface (GUI) for simulating target detection and recognition. The method includes providing a user entry area for receiving user entered ground truth attributes defining one or more respective simulated physical objects, and providing a user entry area for receiving user entered collection attributes defining one or more collections, each collection being a simulation of automated target recognition applied to simulated sensor output associated with simulated sensing of the one or more simulated physical objects. The method further includes simulating detection of the one or more simulated physical objects and recognition based on the ground truth attributes and the collection attributes, generating detection data about at least one detected object based on the simulated target detection, and displaying the detection data.

Abstract: A means and methods are provided to give a gift and simultaneously and unobtrusively record images and/or sound to capture the emotion and excitement of the gift recipient upon receipt of the gift and discovery of the gift-container contents. A gift container is combined with miniaturized video and/or audio recording technologies for use in conjunction with microelectronics and provides a means for recorded data transfer to external devices. Appropriate methods associated with related rentals, sales, and services to the consumer using the gift container are provided.