Abstract: An extendable sled device for transporting luggage or other bulky objects up sets of stairs with less effort. The extendable sled device is integrated with, or attached to, the object being transported. The extendable sled device has an extendable sled controlled by an extension mechanism. The extendable sled is lowered by the extension mechanism when in use, and retracted when not in use. The extendable sled can also have one or more stopper mechanisms, which are used to arrest the luggage on a set of stairs if a user accidently releases the luggage midway up the flight. The stopper mechanisms prevent the luggage from falling back down the steps and potentially injuring people.

Abstract: An extendable sled device for transporting luggage or other bulky objects up sets of stairs with less effort. The extendable sled device is integrated with, or attached to, the object being transported. The extendable sled device has an extendable sled controlled by an extension mechanism. The extendable sled is lowered by the extension mechanism when in use, and retracted when not in use. The extendable sled can also have one or more stopper mechanisms, which are used to arrest the luggage on a set of stairs if a user accidently releases the luggage midway up the flight. The stopper mechanisms prevent the luggage from falling back down the steps and potentially injuring people.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: The present invention relates to a method of providing direct access to webpages of an internet website, of the storage of the links to webpages, and to the evaluation of webpages. The present invention also relates to a mobile device. Methods and apparatus both fall within the scope of the invention. In particular, the present invention relates to systems, methods, apparatus and a software solution for providing internet users with a more rapid access to web pages within an internet website by providing users with their own searchable Personal Internet Directory (PID). The directory is preferably tailored to the preferences of individual users or classes of user and is searchable by the user via cached entries local to the user.

Abstract: A contoured seat generally includes a seat surface for supporting the thighs and buttocks of a sitter and a back surface for supporting the lower back of a sitter. Defined by the seat surface are a pair of bilateral, spaced protrusions that are positioned to extend into piriformis musculature of the sitter. Preferably, the seat surface is inclined at a 5° to 15°, and more preferably a 7.5°, angle to induce forward pelvic tilt in conjunction with lower lumbar support of a forward angle of the back surface. The seat and back surfaces may define a sacral-coccyx pocket that has a depth that varies, along its proximal-distal path to allow for sacral stabilization. The sacral-coccyx pocket preferably is relatively narrow and deep proximally and flares as it extends in the distal direction. A reinforcing ridge may extend across a top edge of the sacral-coccyx pocket to provide additional support.

Abstract: A digital adaptive power supply interface has two feedback loops, each including a VCO, to automatically compensate for temperature and semiconductor process variations. A first loop compares the system input phase/frequency to a reference voltage that has been converted to a first digital frequency signal by a VCO in the first loop, and generates an analog difference signal. The second loop compares this analog difference with the power supply output voltage, and a VCO in this second loop converts result of this comparison to a second digital frequency signal. The digital frequency signals of the two loops are fed respectively to two registers and the content of the registers are subtracted, one from the other, to generate a digital error signal adjust the power supply output voltage to the input frequency.

Abstract: A digital adaptive power supply interface has two feedback loops, each including a VCO, to automatically compensate for temperature and semiconductor process variations. A first loop compares the system input phase/frequency to a reference voltage that has been converted to a first digital frequency signal by a VCO in the first loop, and generates an analog difference signal. The second loop compares this analog difference with the power supply output voltage, and a VCO in this second loop converts result of this comparison to a second digital frequency signal. The digital frequency signals of the two loops are fed respectively to two registers and the content of the registers are subtracted, one from the other, to generate a digital error signal adjust the power supply output voltage to the input frequency.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their,preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).