Abstract: A debris guard for installation on an eavestrough is disclosed. The debris guard includes a frame having a back side, a front side, a length, two ends, a top surface, a bottom surface opposite the top surface, and a water collection portion extending from the front side to the back side and along the length of the frame between the two ends. The water collection portion includes a plurality of holes to allow rainwater to pass through. The water collection portion also includes a plurality of drip legs coupled to the plurality of holes, the plurality of drip legs extending below the bottom surface to provide improved water flow through the eavestrough debris guard. Each of the plurality of holes includes at least one drip leg that provide improved flow through the debris guard.

Abstract: Disclosed herein are analogues of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors, formulations thereof, including lipsome formulations thereof. The compounds are expected to be useful in the treatment of cell proliferation disorders such as cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.

Abstract: A debris guard for installation on an eavestrough is disclosed. The debris guard including a frame with a back side, a front side, a length and two ends. The frame having a water collection portion between the front side and the back side that extends along the length of the frame, the water collection portion having a plurality of holes to allow rainwater to pass through. The frame having a connector engagement structure that extends outward from a surface of the water collection portion, the connector engagement structure being shaped and/or sized to attach with a connector for joining pieces or lengths of the frame together.