Patents by Inventor Matthew Hamilton

Matthew Hamilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of ATP-binding cassette transporters
    Patent number: 9216969
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: December 22, 2015
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D. J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou
  • Modulators of ATP-binding cassette transporters
    Patent number: 8993600
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: March 31, 2015
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D. J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20150065500
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: September 11, 2014
    Publication date: March 5, 2015
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida-Ruah, Matthew Hamilton, Mark Miller, Peter D.J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou, Frederick van Goor
  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20150025076
    Abstract: The present invention relates to modulator of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 22, 2015
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Reverse shoulder humeral adapter trays
    Patent number: 8888855
    Abstract: Disclosed herein are components of a reverse shoulder prosthesis. In an embodiment, a reverse shoulder prosthesis includes a humeral adapter tray configured to sit near a resected surface of a humerus, the humeral adapter tray comprising: a cavity; a central bore; and a distal face including a boss, the boss: (i) configured as an extension of the distal face, (ii) posteriorly offset from the central bore by at least 10 mm, and (iii) configured to engage a humeral stem; and a humeral liner comprising: a distal rim configured to sit within the cavity of the humeral adapter tray; and a concave articulating surface configured to mate with a convex articulating surface of a glenosphere. In an embodiment, the boss, in addition to being posteriorly offset, is superiorly offset from the central bore by at least 8 mm. In an embodiment, the reverse shoulder a humeral stem which engages the boss.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: November 18, 2014
    Assignee: Exactech, Inc.
    Inventors: Christopher Roche, Matthew Hamilton, Phong Diep
  • Modulators of ATP-binding cassette transporters
    Patent number: 8853415
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: October 7, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D. J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 8759335
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: June 24, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida Ruah, Peter Grootenhuis, Mark Miller, Matthew Hamilton
  • Modulators of ATP-binding cassette transporters
    Patent number: 8741933
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: June 3, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D. J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou
  • Modulators of ATP-binding cassette transporters
    Patent number: 8741939
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: June 3, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D. J. Grootenhuis
  • ELECTRONIC PUBLISHING MECHANISMS
    Publication number: 20140129959
    Abstract: A content publisher can use a publisher tool to tag various content elements, which enables a user viewing content from the publisher to view related advertising. In at least some embodiments, the tool is a toolbar that the publisher can use to tag content elements such as images and text, whereby the toolbar can recommend related items to be linked to those content elements. The items can be associated with an entity, such as an advertiser or electronic retailer, that will provide some level of compensation to the publisher in return for the linking. Such an approach enables the publisher to monetize the content in a way that is minimally intrusive for the end user.
    Type: Application
    Filed: April 18, 2013
    Publication date: May 8, 2014
    Applicant: Amazon Technologies, Inc.
    Inventors: Matthew Hamilton Battles, Pradeep Desai, Balaji Hariharan Chandra, Prasanth Radhakrishnan, Harshit Beri, Gaurav Gupta, Vignesh Annamalai Paramadhayalan
  • Modulators of ATP-binding cassette transporters
    Publication number: 20140080825
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: August 21, 2013
    Publication date: March 20, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Sabina Hadida-Ruah, Peter Diederik Jan Grootenhuis, Mark Thomas Miller, Matthew Hamilton
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20140072995
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: November 14, 2013
    Publication date: March 13, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 8642609
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: February 4, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Ashavini K. Singh, Mark T. Miller, Sarah S. Hadida Ruah, Peter D. J. Grootenhuis, Matthew Hamilton, Anna Ruth Hazlewood, Liming Huang
  • REVERSE SHOULDER HUMERAL ADAPTER TRAYS
    Publication number: 20130325131
    Abstract: Disclosed herein are components of a reverse shoulder prosthesis. In an embodiment, a reverse shoulder prosthesis includes a humeral adapter tray configured to sit near a resected surface of a humerus, the humeral adapter tray comprising: a cavity; a central bore; and a distal face including a boss, the boss: (i) configured as an extension of the distal face, (ii) posteriorly offset from the central bore by at least 10 mm, and (iii) configured to engage a humeral stem; and a humeral liner comprising: a distal rim configured to sit within the cavity of the humeral adapter tray; and a concave articulating surface configured to mate with a convex articulating surface of a glenosphere. In an embodiment, the boss, in addition to being posteriorly offset, is superiorly offset from the central bore by at least 8 mm. In an embodiment, the reverse shoulder a humeral stem which engages the boss.
    Type: Application
    Filed: May 30, 2013
    Publication date: December 5, 2013
    Applicant: Exactech, Inc.
    Inventors: Christopher Roche, Matthew Hamilton, Phong Diep
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20130252333
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 26, 2013
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Ashvani K. Singh, Thomas Cleveland, Lewis R. Makings, Matthew Hamilton, Peter D.J. Grootenhuis
  • Modulators of ATP-binding cassette transporters
    Patent number: 8541453
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: September 24, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Sabina Hadida-Ruah, Peter Diederik Jan Grootenhuis, Mark Thomas Miller, Matthew Hamilton
  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20130245010
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: April 26, 2013
    Publication date: September 19, 2013
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D.J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20130245011
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: May 6, 2013
    Publication date: September 19, 2013
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D.J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou
  • MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20130237569
    Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: April 26, 2013
    Publication date: September 12, 2013
    Inventors: Sara S. Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D.J. Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou
  • Novelty clip for attachment to shoelace
    Patent number: D737564
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: September 1, 2015
    Inventors: Matthew Hamilton, Derek Malpass