Abstract: Crosslinked hydrogel-based transdermal pharmaceutical formulations. The hydrogel transdermal formulations. Transdermal patches are useful for administering a variety of drugs to patients. The transdermal patches here employ crosslinked-hydrogels generated through irradiation, thus eliminating any residual effects associated with chemical- or UV-based crosslinking procedures. The transdermal patches may be formed from a variety of high-molecular weight polymeric compounds and include substantial levels of water to improve skin tolerance by the patient. The transdermal patches may also include transcutol as a solvent for the drug, which has been found to increase the effectiveness of drug delivery. The present disclosure also provides for methods of loading a drug into a transdermal formulation after the crosslinking of the hydrogel, thus improving stability and bioavailability through avoiding exposure of the drug to the radiation used in the crosslinking procedure.

Abstract: Crosslinked hydrogel-based transdermal pharmaceutical formulations. The hydrogel transdermal formulations. Transdermal patches are useful for administering a variety of drugs to patients. The transdermal patches here employ crosslinked-hydrogels generated through irradiation, thus eliminating any residual effects associated with chemical- or UV-based crosslinking procedures. The transdermal patches may be formed from a variety of high-molecular weight polymeric compounds and include substantial levels of water to improve skin tolerance by the patient. The transdermal patches may also include transcutol as a solvent for the drug, which has been found to increase the effectiveness of drug delivery. The present disclosure also provides for methods of loading a drug into a transdermal formulation after the crosslinking of the hydrogel, thus improving stability and bioavailability through avoiding exposure of the drug to the radiation used in the crosslinking procedure.

Abstract: An antimicrobial composite is provided, comprising a catalyst capable of promoting oxidation of organic molecules incorporated in a carrier, for example a hydrophilic or water-based material, the catalyst configured such that it will not discolor surrounding material under the influence of oxidative conditions

Abstract: A method of making a hydrogel having antimicrobial properties. The hydrogel includes a hydrogel-forming polymer and an anti-microbial agent. The method includes mixing a hydrogel-forming polymer, such as a hydrophilic polymer, with water and cross-linking the polymer and water using an energy source. The method does not require any chemical additive to affect the cross-linking. The anti-microbial agent may be mixed with the hydrogel-forming polymer and water prior to cross-linking. Alternatively, the anti-microbial agent may be applied to a substrate onto which the hydrogel is placed such that the anti-microbial agent or the properties of the agent, or both, migrate into the hydrogel. The substrate may be a liner onto which the hydrogel is placed, a scrim located on or in the hydrogel, or other appropriate device.