Patents by Inventor Matthew Hassler

Matthew Hassler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250243492
    Abstract: The present disclosure provides single- or double-stranded interfering RNA molecules (e.g., siRNA) that target a PRNP gene. The interfering RNA molecules may contain specific patterns of nucleoside modifications and internucleoside linkage modifications, as pharmaceutical compositions including the same. The siRNA molecules may be branched siRNA molecules, such as di-branched, tri-branched, or tetra-branched siRNA molecules. The disclosed siRNA molecules may further feature a 5? phosphorus stabilizing moiety and/or a hydrophobic moiety. Additionally, the disclosure provides methods for delivering the siRNA molecule of the disclosure to the central nervous system of a subject, such as a subject identified as having a prion disease or a high-penetrance PRNP mutation.
    Type: Application
    Filed: October 4, 2022
    Publication date: July 31, 2025
    Inventors: Matthew HASSLER, Daniel CURTIS
  • Publication number: 20250109402
    Abstract: The present disclosure provides single- or double-stranded interfering RNA molecules (e.g., siRNA) that target a SCN9A gene. The interfering RNA molecules may contain specific patterns of nucleoside modifications and internucleoside linkage modifications, as pharmaceutical compositions including the same. The siRNA molecules may be branched siRNA molecules, such as di-branched, tri¬branched, ortetra-branched siRNA molecules. The disclosed siRNA molecules may further feature a 5? phosphorus stabilizing moiety and/or a hydrophobic moiety. Additionally, the disclosure provides methods for delivering the siRNA molecule of the disclosure to the central nervous system of a subject, such as a subject experiencing pain or identified as having a pain disorder.
    Type: Application
    Filed: December 1, 2022
    Publication date: April 3, 2025
    Inventors: Stefan I. MCDONOUGH, Corrie GALLANT-BEHM, Matthew HASSLER, Daniel CURTIS, Bruno Miguel Da Cruz GODINHO
  • Publication number: 20250059533
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: July 11, 2024
    Publication date: February 20, 2025
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin
  • Patent number: 12180477
    Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
    Type: Grant
    Filed: April 20, 2022
    Date of Patent: December 31, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, Matthew Hassler
  • Patent number: 12173286
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: December 24, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman, Matthew Hassler
  • Publication number: 20240293550
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Application
    Filed: December 26, 2023
    Publication date: September 5, 2024
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • Patent number: 12077755
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: September 3, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin
  • Publication number: 20240287526
    Abstract: The present disclosure provides single- or double-stranded therapeutic oligonucleotides (e.g., siRNAs, shRNAs, miRNAs, gRNAs, and ASOs) having a plurality of cationic binding sites that are partially or fully saturated by a plurality of divalent cations (e.g., Ba2+, Be2+, Ca2+, Cu2+, Mg2+, Mn2+, Ni2+, or Zn2+, or a combination thereof). The therapeutic oligonucleotides may contain specific patterns of nucleoside modifications and internucleoside linkage modifications, as pharmaceutical compositions including the same. The siRNA molecules may be branched siRNA molecules, such as di-branched, tri-branched, or tetra-branched siRNA molecules. The disclosed siRNA molecules may further feature a 5? phosphorus stabilizing moiety and/or a hydrophobic moiety. Additionally, the disclosure provides methods for delivering the siRNA molecule of the disclosure to the central nervous system of a subject, such as a subject identified as having a disease.
    Type: Application
    Filed: June 2, 2022
    Publication date: August 29, 2024
    Inventors: Matthew HASSLER, Garth A. KINBERGER, Bruno Miguel Da Cruz GODINHO
  • Patent number: 12049627
    Abstract: Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: July 30, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Matthew Hassler
  • Publication number: 20240182904
    Abstract: Provided herein are oligonucleotides (e.g., siRNA) targeting S6K1. Also provided are methods of treating a disease associated with S6K1 expression.
    Type: Application
    Filed: September 29, 2023
    Publication date: June 6, 2024
    Inventors: Claudio Punzo, Anastasia Khvorova, Dimas Echeverria Moreno, Annabelle Biscans, Julia F. Alterman, Matthew Hassler, Shun-Yun Cheng, Jillian Caiazzi
  • Publication number: 20240182892
    Abstract: The present disclosure provides single- or double-stranded short interfering RNA (siRNA) molecules having specific patterns of nucleoside modifications and internucleoside linkage modifications, as pharmaceutical compositions including the same. The siRNA molecules may be branched siRNA molecules, such as di-branched, tri-branched, ortetra-branched siRNA molecules. The disclosed siRNA molecules may further feature a 5? phosphorus stabilizing moiety and/or a hydrophobic moiety. Additionally, the disclosure provides methods for delivering the siRNA molecule of the disclosure to the central nervous system of a subject, such as a subject identified as having a disease.
    Type: Application
    Filed: March 24, 2022
    Publication date: June 6, 2024
    Inventors: Matthew HASSLER, Daniel CURTIS, Bruno Miguel DA CRUZ GODINHO
  • Publication number: 20240173420
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific eye distribution.
    Type: Application
    Filed: September 29, 2023
    Publication date: May 30, 2024
    Inventors: Claudio Punzo, Anastasia Khvorova, Dimas Echeverria Moreno, Annabelle Biscans, Julia F. Alterman, Matthew Hassler, Shun-Yun Cheng
  • Publication number: 20240084297
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Application
    Filed: February 16, 2023
    Publication date: March 14, 2024
    Inventors: Anastasia KHVOROVA, Mehran NIKAN, Matthew HASSLER, Maire OSBORN, Reka HARASZTI, Andrew COLES, Anton TURANOV, Neil ARONIN, Annabelle BISCANS
  • Patent number: 11896669
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman, Bruno Miguel da Cruz Godinho
  • Patent number: 11753638
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: September 12, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin, Annabelle Biscans
  • Publication number: 20230061751
    Abstract: Therapeutic oligonucleotides comprising universal pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more universal PK-modifying anchors are provided.
    Type: Application
    Filed: January 15, 2021
    Publication date: March 2, 2023
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, Matthew Hassler
  • Publication number: 20220372476
    Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
    Type: Application
    Filed: April 20, 2022
    Publication date: November 24, 2022
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, Matthew Hassler
  • Patent number: 11492619
    Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: November 8, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Bruno Miguel Da Cruz Godinho, Matthew Hassler
  • Publication number: 20210388348
    Abstract: Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5? and/or 3? conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: May 12, 2021
    Publication date: December 16, 2021
    Inventors: Erik Joseph Sontheimer, Anastasia Khvorova, Jonathan Kenneth Watts, Nadia Amrani, Zexiang Chen, Matthew Hassler, Dimas Echeverria Moreno, Julia Frances Alterman, Scot Wolfe, Ken Yamada, Gitali Devi, Han Zhang
  • Publication number: 20210300954
    Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II): processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
    Type: Application
    Filed: May 21, 2021
    Publication date: September 30, 2021
    Inventors: Masad J. Damha, Matthew Hassler, Tak-Hang Chan, Mallikarjuna Reddy Nandyala, Robert Alexander Donga