Abstract: Methods, systems and non-transitory computer readable storage media of electric field treatment planning of a target tissue. A method of electric field treatment planning of a target tissue site includes: (a) obtaining an image of the target tissue site, (b) determining volume and one or more electric properties of the target tissue site, (c) using the volume and the one or more electric properties to: (i) determine a number of electrodes to treat the target tissue site with electric fields, each electrode having one or more contacts, (ii) determine a placement of the number of electrodes within the target tissue site, and (iii) relative to one of the contacts in one of the number of electrodes at the placement determined in (ii), determine an electric field that results in a prescribed electric field coverage of the target tissue site.