Abstract: The invention relates to vascular remodelling, and to the treatment of conditions that are characterised or caused by inappropriate vascular remodelling. The invention also extends to pharmaceutical compositions for use in treating such conditions, and to methods of treatment.

Abstract: An aluminum ingot casting machine comprising a source of molten metal, a rotatable annular ring, carrying ingot casting moulds and a drive means for indexing the moulds. The machine includes a vacuum demoulder having a vacuum seal arrangement comprising a sealing element having a flexible core which can deform to form a vacuum seal against an ingot and a flexible abrasion resistant outer layer on said core, and retaining elements located on a lower face of the vacuum lifting head for releasably retaining the sealing element onto the lifting head. The vacuum seal comprises a flexible ring shaped body, being rounded in cross section, having a fibre cord core and an abrasion resistant flexible sheathing surrounding the core.

Abstract: A canister for use with a chemical oxygen generation cell. In some embodiments, the canister includes two main canister assemblies. One assembly houses the briquette, the ignition cone, and one or more filters. A second assembly houses a thimble and one or more filters. Once the components are placed within each assembly, the two assemblies can then be easily joined together to form the cell. In some embodiments, the sealed canister is constructed with at least one weakened area along at least one canister wall. Upon premature activation of the cell, pressure within the sealed canister causes at least one controlled rupture in the weakened area of the canister to vent gases and prevent an explosion.

Abstract: A device for assisting thought processes in decision making. The device is a book having a front cover bearing a title in characters and a rear cover bearing the title but wherein the characters comprising the title are inverted with respect to the front cover. Thus, the book may be opened sensibly from either the front or the back. A plurality of pages, each page bearing self-contained text, are disposed between the front and rear covers with the text inverted on alternate pages. A person contemplates a problem then opens the book either from the front or the rear to reveal a random page. The text that appears in non-inverted characters on the exposed page is read to provide guidance in solving the problem.