Abstract: Provided herein are compounds for inhibiting monoacylglycerol lipase (MAGL), and related methods of making and using the compounds.

Abstract: Provided herein are 1H-pyrazol-5-yl)-2-azaspiro[3.3]heptan-2-yl methanone compounds substituted with aryl and pyrazolyl moieties, further substituted, for inhibiting monoacylglycerol lipase (MAGL), utilized in the treatment of a MAGL-mediated disease or disorder i.e., neurodegenerative diseases, pain, and inflammatory diseases or conditions, as well as cancer, and related methods of making and using the compounds.

Abstract: Provided herein are compounds for inhibiting monoacylglycerol lipase (MAGL), and related methods of making and using the compounds.

Abstract: A cost estimator system receives a plan, a configuration or proposed changes for a cloud-based infrastructure, and which include data representing one or more computing resources needed for a cloud-based application. A new configuration is generated for the cloud-based infrastructure incorporating the plan, configuration or proposed changes. A price resolver resolves a price of the resources that are part of the new configuration, and requests, from one or more cloud providers associated with the new configuration, price data for the resolved resources. The cost estimator system then generates, based on the price data received by the price resolver, a cost estimate for the new configuration of the cloud-based infrastructure.

Abstract: A cost estimator system receives a plan, a configuration or proposed changes for a cloud-based infrastructure, and which include data representing one or more computing resources needed for a cloud-based application. A new configuration is generated for the cloud-based infrastructure incorporating the plan, configuration or proposed changes. A price resolver resolves a price of the resources that are part of the new configuration, and requests, from one or more cloud providers associated with the new configuration, price data for the resolved resources. The cost estimator system then generates, based on the price data received by the price resolver, a cost estimate for the new configuration of the cloud-based infrastructure.

Abstract: A cost estimator system receives a plan, a configuration or proposed changes for a cloud-based infrastructure, and which include data representing one or more computing resources needed for a cloud-based application. A new configuration is generated for the cloud-based infrastructure incorporating the plan, configuration or proposed changes. A price resolver resolves a price of the resources that are part of the new configuration, and requests, from one or more cloud providers associated with the new configuration, price data for the resolved resources. The cost estimator system then generates, based on the price data received by the price resolver, a cost estimate for the new configuration of the cloud-based infrastructure.

Abstract: Provided herein are compounds that inhibit HDAC6, a protein whose activity is associated with a variety of diseases (e.g., cancer, neurological disorders). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HDAC6-related diseases and disorders (e.g., Alzheimer's disease, cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Abstract: A cost estimator system receives a plan, a configuration or proposed changes for a cloud-based infrastructure, and which include data representing one or more computing resources needed for a cloud-based application. A new configuration is generated for the cloud-based infrastructure incorporating the plan, configuration or proposed changes. A price resolver resolves a price of the resources that are part of the new configuration, and requests, from one or more cloud providers associated with the new configuration, price data for the resolved resources. The cost estimator system then generates, based on the price data received by the price resolver, a cost estimate for the new configuration of the cloud-based infrastructure.

Abstract: A cost estimator system receives a plan, a configuration or proposed changes for a cloud-based infrastructure, and which include data representing one or more computing resources needed for a cloud-based application. A new configuration is generated for the cloud-based infrastructure incorporating the plan, configuration or proposed changes. A price resolver resolves a price of the resources that are part of the new configuration, and requests, from one or more cloud providers associated with the new configuration, price data for the resolved resources. The cost estimator system then generates, based on the price data received by the price resolver, a cost estimate for the new configuration of the cloud-based infrastructure.

Abstract: Isotopically labeled formaldehyde (*C§H2O) is prepared from labeled methyl iodide (*C§H3I) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *C§H2O with little or no *C isotopic dilution. The simple, efficient production of 11CH2O is described. The use of the 11CH2O for the formation of positron emission tomography tracer compounds is described. The reaction can be incorporated into automated equipment available to radiochemistry laboratories. The isotopically labeled formaldehyde can be used in a variety of reactions to provide radiotracer compounds for imaging studies as well as for scintillation counting and autoradiography.

Abstract: Isotopically labeled formaldehyde (*C§H2O) is prepared from labeled methyl iodide (*C§H3I) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *C§H2O with little or no *C isotopic dilution. The simple, efficient production of 11CH2O is described. The use of the 11CH2O for the formation of positron emission tomography tracer compounds is described. The reaction can be incorporated into automated equipment available to radiochemistry laboratories. The isotopically labeled formaldehyde can be used in a variety of reactions to provide radiotracer compounds for imaging studies as well as for scintillation counting and autoradiography.

Abstract: Methods are provided of producing a heater cable. An electrical conductor is coated with a preceramic resin. At least a portion of the coated electrical conductor is deployed into a operational location. The preceramic resin is pyrolyzed while the portion of the coated electrical conductor is in the operational location to convert the preceramic resin into a ceramic insulator disposed to electrically insulate the electrical conductor from the sheath.