Abstract: Disclosed fluid reservoirs include a 3-D formed first sheet and a 3-D formed second sheet. The 3-D formed first sheet and the 3-D formed second sheet are sealed together at least partially around respective perimeter edges thereof to define an internal space for fluid storage, There is a first opening defined between the 3-D formed first sheet and the 3-D formed second sheet at a first end of the fluid reservoir. The first opening is configured for filling the fluid reservoir with fluid. There is a second opening defined between the 3-D formed first sheet and the 3-D formed second sheet at a second end of the fluid reservoir opposite the first end. The second opening has a fluid exit port configured for allowing fluid to exit the fluid reservoir. The reservoir can include an optional baffle that is coupled to the 3-D formed first and second sheets.

Abstract: Disclosed are flexible fluid reservoirs including a front sheet and a back sheet, each comprising a four-layer insulated wall. The four-layer insulated wall includes an interior layer and an exterior layer, and a metallic film layer and an insulation layer disposed between the interior layer and the exterior layer where the metallic film layer is oriented toward the exterior layer and the insulation layer is oriented toward the interior layer. One or more of the interior or exterior layers can be a metallocene modified polyethylene film. The metallic film layer can be aluminum coated polyethylene terephthalate resin. The insulation layer can be a foam layer comprising closed cell polyethylene resin. The four-layer insulated wall can resist or limit temperature changes of a fluid disposed within the reservoir for a period of time. The insulated fluid reservoirs can include closure mechanisms for sealing an upper opening of the reservoir.

Abstract: Disclosed fluid reservoirs include closure mechanisms for sealing an upper opening of the reservoir. The reservoir can have plates adjacent the upper opening. When the upper end of the reservoir is folded, the plates can be positioned on opposite sides, and a closure frame can be slid over the plates to pressure them together. The plates can have pins that engage with slots in the closure frame, and a separate closure lock can be slid over the end of the closure frame to prevent the pins from exiting the slots. The plates can also bias the opening open when the closure is not engaged. Also disclosed are flexible fluid reservoirs that include structural elements, such as baffles, that help retain a desired shape of the reservoir when filled or empty. Some baffles can be elastically deformable to allow flattening and expansion of the bladder while biasing toward a neutral position.

Abstract: Disclosed fluid reservoirs include closure mechanisms for sealing an upper opening of the reservoir. The reservoir can have plates adjacent the upper opening. When the upper end of the reservoir is folded, the plates can be positioned on opposite sides, and a closure frame can be slid over the plates to pressure them together. The plates can have pins that engage with slots in the closure frame, and a separate closure lock can be slid over the end of the closure frame to prevent the pins from exiting the slots. The plates can also bias the opening open when the closure is not engaged. Also disclosed are flexible fluid reservoirs that include structural elements, such as baffles, that help retain a desired shape of the reservoir when filled or empty. Some baffles can be elastically deformable to allow flattening and expansion of the bladder while biasing toward a neutral position.

Abstract: The present disclosure relates to methods of determining whether a subject has cancer. More particularly, the present disclosure relates to a method of determining whether a subject has cancer when a pathological assessment of cell morphology is negative for the cancer. More particularly, the present disclosure relates to a method of determining whether a morphologically normal cell is malignant. Identification of malignant cells, when a pathological assessment of cell morphology is negative for cancer, is based upon detecting the binding of an anti-telomerase antibody to clinically relevant cells.

Abstract: A bite valve retention system can comprise a base comprising a pivot portion and one or more side portions, wherein the one or more side portions are configured to receive a portion of a strap; and a retention element comprising a first portion and a second portion, wherein the first portion is pivotably coupled to the pivot portion of the base such that the retention element pivots around an axis perpendicular to the pivot portion, and the second portion comprises a first coupling mechanism and extends from the first portion along an outer surface of the base; wherein the first coupling mechanism is configured to allow the retention element to couple and decouple from a second coupling mechanism disposed on an outer surface of a bite valve.

Abstract: Disclosed fluid reservoirs include closure mechanisms for sealing an upper opening of the reservoir. The reservoir can have plates adjacent the upper opening. When the upper end of the reservoir is folded, the plates can be positioned on opposite sides, and a closure frame can be slid over the plates to pressure them together. The plates can have pins that engage with slots in the closure frame, and a separate closure lock can be slid over the end of the closure frame to prevent the pins from exiting the slots. The plates can also bias the opening open when the closure is not engaged. Also disclosed are flexible fluid reservoirs that include structural elements, such as baffles, that help retain a desired shape of the reservoir when filled or empty. Some baffles can be elastically deformable to allow flattening and expansion of the bladder while biasing toward a neutral position.

Abstract: A valve assembly includes a housing, a collar, a sheath fixedly coupled to the collar, and a stem assembly. The collar and the sheath can be axially moveable relative to the housing between a first position, a second position, and a third position. In the first position, a fluid inside a lumen of the housing can be blocked from flowing into a lumen of the collar. In the second position, the fluid inside the lumen of the housing can flow through the lumen of the collar and into a chamber of the sheath. The fluid can be retained therein or flow out of the sheath through an aperture when the sheath is selectively deformed. In the third position, the fluid inside the lumen of the housing can flow through the lumen of the collar and the chamber, and then flow out of the sheath unobstructed through the aperture.

Abstract: Disclosed herein are embodiments of hydration bladders that include flexible wall portions along with relatively more rigid structural portions that are shaped to help define the shape of the bladder and can also help a user grip and manipulate the bladder. The structural portions can also support or incorporate other bladder features, such as inlet ports, caps, outlet ports, valves, tubes, attachment points, graphic designs, and/or other features. Some embodiments include an outlet tube that is retractable and extendable through an upper port at the top of the bladder.

Abstract: A bite valve retention system can comprise a base comprising a pivot portion and one or more side portions, wherein the one or more side portions are configured to receive a portion of a strap; and a retention element comprising a first portion and a second portion, wherein the first portion is pivotably coupled to the pivot portion of the base such that the retention element pivots around an axis perpendicular to the pivot portion, and the second portion comprises a first coupling mechanism and extends from the first portion along an outer surface of the base; wherein the first coupling mechanism is configured to allow the retention element to couple and decouple from a second coupling mechanism disposed on an outer surface of a bite valve.

Abstract: A valve assembly includes a housing, a collar, a sheath fixedly coupled to the collar, and a stem assembly. The collar and the sheath can be axially moveable relative to the housing between a first position, a second position, and a third position. In the first position, a fluid inside a lumen of the housing can be blocked from flowing into a lumen of the collar. In the second position, the fluid inside the lumen of the housing can flow through the lumen of the collar and into a chamber of the sheath. The fluid can be retained therein or flow out of the sheath through an aperture when the sheath is selectively deformed. In the third position, the fluid inside the lumen of the housing can flow through the lumen of the collar and the chamber, and then flow out of the sheath unobstructed through the aperture.

Abstract: Disclosed herein are embodiments of hydration bladders that include flexible wall portions along with relatively more rigid structural portions that are shaped to help define the shape of the bladder and can also help a user grip and manipulate the bladder. The structural portions can also support or incorporate other bladder features, such as inlet ports, caps, outlet ports, valves, tubes, attachment points, graphic designs, and/or other features. Some embodiments include an outlet tube that is retractable and extendable through an upper port at the top of the bladder.

Abstract: A fluid container can comprise a flexible bladder having an internal region for storing a fluid, a bladder opening at an upper end portion of the bladder for allowing passage of fluid in or out of the internal region, a lower rigid member secured to an outer surface of the bladder at a lower end portion of the bladder, an upper closure secured to the bladder over the bladder opening for selectively closing and opening the bladder opening, and a rigid, removable handle, wherein the handle has an upper end portion that is detachably coupled to the upper closure and a lower end portion that is detachably coupled to the lower rigid member.

Abstract: A fluid container can comprise a flexible front sheet having an upper edge and lateral edges, and a flexible rear sheet having upper edges and lateral edges. The front sheet and the rear sheet can be joined at their lateral edges to form an internal region from storing fluid. An upwardly facing spout assembly can comprise an insert coupled to and positioned between the upper edge portions of the first and second sheets, wherein the insert comprises a sealable fluid port.

Abstract: A flexible container assembly that combines insulation, ease-of-carrying, and user-friendly drinking and is packaged to offer a wide range of style choices. The container assembly includes protection of mouth-contacting surfaces, easy cleaning, and spill protection among the other advantages. The invention comprises of a flexible container featuring a neck that seals upon folding itself into a downward position and works with a sealable mouthpiece at its top end to prevent the outflow of fluids. The container of the assembly uses a wide-mouth screw-port base to enable easier filling and cleaning. The assembly utilizes an integrated insulating flexible cover which features securable openings to access the bottle ports, as well as carrying handles, finger loops, attachment hooks, and pockets.

Abstract: The present invention relates to a compressive band and hemostatic dressing system and related methods of use to provide rapid, non-occlusive bleeding control, arterial injury treatment, and injury protection comfortably and reliably after vascular access procedures. The present invention may comprise some or all of the following elements: a positioner assembly, a compressive cushion component, a compression plate, a strap with a flexible hinge assembly, and a hemostatic dressing. In a preferred embodiment, the systems and methods are applied to treat and ameliorate vascular injury in a transradial percutaneous access procedure and protect against underlying vascular injury; however, the systems and methods described herein may be applied to any vascular access procedure including arm or leg vascular approaches such as the femoral, brachial, dorsalis pedis or tibial blood vessels in arterial or venous line or sheath removal or trocar removal, and in hemodialysis.

Abstract: The present disclosure relates to methods of determining whether a subject has cancer. More particularly, the present disclosure relates to a method of determining whether a subject has cancer when a pathological assessment of cell morphology is negative for the cancer. More particularly, the present disclosure relates to a method of determining whether a morphologically normal cell is malignant. Identification of malignant cells, when a pathological assessment of cell morphology is negative for cancer, is based upon detecting the binding of an anti-telomerase antibody to clinically relevant cells.

Abstract: The present invention relates to a compressive band and hemostatic dressing system and related methods of use to provide rapid, non-occlusive bleeding control, arterial injury treatment, and injury protection comfortably and reliably after vascular access procedures. The present invention may comprise some or all of the following elements: a positioner assembly, a compressive cushion component, a compression plate, a strap with a flexible hinge assembly, and a hemostatic dressing. In a preferred embodiment, the systems and methods are applied to treat and ameliorate vascular injury in a transradial percutaneous access procedure and protect against underlying vascular injury; however, the systems and methods described herein may be applied to any vascular access procedure including arm or leg vascular approaches such as the femoral, brachial, dorsalis pedis or tibial blood vessels in arterial or venous line or sheath removal or trocar removal, and in hemodialysis.

Abstract: Disclosed herein are fluid bladders that include a port and a port closure, a handle, and/or other components. Some disclosed closures can be configured to provide at least two different sized openings for accessing the reservoir, as well as providing a sealing and/or locking mechanism to close the port and seal the port. Exemplary closures comprising a base defining a fill port and mounted to a wall of the bladder, a first cap component that is attached to the base, and a second cap component (e.g., a lid) that is attachable and detachable (via threaded engagement, a pivoting snap fit, or otherwise) to the first cap component. The base can be fixed (e.g., welded) to the bladder to cover the bladder wall opening and provide a second, rigid opening, or port.