Abstract: Provided herein are method of using GLP1-GDF15 fusion proteins for reducing food intake, preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others, the fusion protein comprising a GLP1 or GLP1 variant peptide, a first linker peptide, a serum albumin protein, a second linker peptide, and a GDF15 protein.

Abstract: A wood-style golf club head includes a strike face and a body that cooperate to define a hollow internal club head volume. The strike face formed from a strike plate having an outer perimeter and a frame surrounding the strike plate. The strike plate is affixed to the frame across the entire outer perimeter. The strike plate and frame define a continuous ball striking surface that has a surface texture characteristic of milling that extends continuously across both the strike plate and the frame.

Abstract: Control logic in a memory device executes a programming operation to program the set of memory blocks of the set of memory planes to a set of a programming levels. The control logic identify a subset of memory blocks of one or more memory planes that pass a program count operation associated with a last programming level of the set of programming levels. The control logic further terminates execution of the programming operation on the one or more memory planes associated with the subset of memory blocks.

Abstract: An optical chip may include a vertical-cavity surface-emitting laser (VCSEL) structure. The optical chip may include a capacitor over at least a portion of an active layer of the VCSEL structure that is outside of an active region of the VCSEL structure. The capacitor may include a first metal layer over the portion of the active layer, a dielectric layer on the first metal layer, and a second metal layer on the dielectric layer. The optical chip may include an isolation region between a substrate of the VCSEL and a portion of the capacitor outside of the VCSEL.

Abstract: Provided herein are piperidine dione compounds having the following structure: (I) wherein R1, R2, R3, R4, RN, L, V, X, Y, A, A?, a, n and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided is a system for drug delivery utilizing hydrogel to deliver biologically active agents to stimulate mature intratumoral tertiary lymphoid structure formation and augment immune check point blockade. Provided herein is an injectable hydrogel that can stimulate the formation of immune structures within tumors, improving cancer prognosis and treatment response. Provided is a method of treating cancer. Also provided is a method of making the drug delivery system.

Abstract: Stability to long term charge and discharge cycles is the most formidable challenge for Lithium-Sulfur batteries. Therefore, a more holistic design of a durable cathode with minimal polysulfide escape to mitigate the corrosion of the lithium anode is required. A saccharide-based binder system—the monosaccharide (glucose) component, on account of being a strong reducing agent has a unique capacity for the regulation of polysulfide thereby dramatically enhancing the functionality of a polysaccharide (carboxymethyl cellulose) binder system. The two-component binder system promotes the formation of viscoelastic filaments during casting which endows sulfur cathode a desired web-like microstructure. The combination of these effects leads to 97% sulfur utilisation with an ultra-long cycle life of 1000 cycles (9 months) and a high capacity retention (around 700 mAhg?1 after 1000 cycles). A pouch cell prototype with a capacity of 1200 mAhg?1 demonstrates a promising transition from laboratory to manufacturing options.

Abstract: Aspects of the disclosure are directed to a transactional agent for user interactions. The agent can seamlessly respond to user requests in a conversational manner while maintaining the conversational state. The agent can include a multi-stage modular model architecture, including a semantic understander and a semantic matcher. The semantic understander can be configured to understand common conversation conventions and/or patterns to produce a structure representation of a user request. The semantic matcher can be configured to map items and modifiers to product entries for a particular domain.

Abstract: Provided herein are a fusion protein comprising an interleukin-22 domain and an albumin binding domain, and a pharmaceutical composition thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an inflammatory disease.

Abstract: A method of authenticating a passcode entered by a user on an unstable electronic computing device. The method includes receiving an indication that an input is unstable, impacting the ability of a user to provide the input; generating a dynamic keyboard including at least one alphanumeric key, the dynamic keyboard being configured to address the unstable input; presenting the dynamic keyboard to the user; receiving the input from the user, the input comprising a selection of at least one alphanumeric character of a passcode on the dynamic keyboard; and authenticating the input received from the user by comparing the at least one alphanumeric character and a stored passcode.

Abstract: Systems and techniques for payment processor supported Web 3.0 (“web3”) wallets are provided. The described systems and techniques allow for the use of non-fungible tokens (NFTs) to represent a payment token for making a payment inside a web3 and metaverse environment. Indeed, the described systems and techniques provide a financial NFT enabled representation of a payment card account as a token in a blockchain network, which can then be used to facilitate web3 payments with real-time fiat to crypto exchanges.

Abstract: Systems and methods for automated historical risk assessment for risk mitigation in online access control are provided. An entity assessment server can receive a request to assess a risk indicator change from a first risk indicator to a second risk indicator. For each attribute used to generate the first risk indicator and second risk indicator, a first impact can be determined for changing from the first risk indicator to a third risk indicator between the first risk indicator and the second risk indicator. A second impact similarly can be determined for changing from the third risk indicator to the second risk indicator. Aggregating the first impact and the second impact can determine a total impact of each attribute. Assessment results can be generated to include a list of attributes ordered according to the respective total impact and transmitted to a remote computing device for use in improving the risk indicator.

Abstract: Provided are novel Substituted Thiophene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R7 are as defined herein, as well as compositions comprising at least one Substituted Thiophene Derivative, and methods of using the Substituted Thiophene Derivatives for treating or preventing cancer in a patient.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: In one aspect, a method of confirming identity of an entity is disclosed. The method comprises receiving a plurality of items for delivery to an address, obtaining, from the items, information regarding an entity associated with the items and the address, and delivering the items to the address. The method may also comprise identifying an expected identity of the entity, receiving a request to confirm an identity of the entity using third-party identity verification via a user interface, and determining, based on the information regarding the entity, a confidence score for the expected identity. The method may further comprise determining whether the confidence score is greater than or equal to the threshold value and generating a response to the request. The method may additionally comprises displaying the response via the user interface.

Abstract: The present application provides fusion proteins that comprise a cytokine fused to an albumin binding moiety. The fusion proteins may further comprise an antigen binding moiety such as a therapeutic antibody. The present application also provides methods of making and using the fusion proteins. The present application also provides methods of treatment comprises administering a fusion protein comprising a cytokine fused to a half-life extending domain and a second agent.

Abstract: An iron-type golf club head with a cavity formed via a multi-stage forging process. The forged iron-type golf club head is formed from a single billet of material. An intermediate step of the multi-stage forging process creates a cavity in the iron-type golf club head which can receive an insert. The resultant iron-type golf club head has a substantially lower center of gravity and higher moment of inertia when compared to a traditionally forged iron-type golf club head lacking a cavity. Additionally, the resultant iron-type golf club head has a more solid feel than a traditionally cast iron-type golf club head as a result of the tighter grain structure the forging process yields.

Abstract: Control logic in a memory device executes a programming operation to program the set of memory blocks of the set of memory planes to a set of a programming levels. In response to determining at least a portion of a first memory block passed a program verify operation associated with a last programming level of the set of programming levels, the control logic executes a first program sub-operation to terminate the programming operation with respect to a first subset of one or more memory planes of the set of memory planes that passed the program verify operation associated with the last programming level and identify a second subset of one or more memory planes that failed the program verify operation associated with the last programming level. The control logic executes a second program sub-operation to apply a trim set to the second subset of one or more memory planes that failed the program verify operation of the last programming level.

Abstract: Embodiments perform automatic document handling by retrieving icons from local document handlers or from an application volumes manager, without installing the application locally. Embodiments further perform on-demand application mounting by intercepting and suspending requests to launch applications until the appropriate virtual disk, corresponding to the application, is mounted to the disk subsystem by the application volumes manager. The application launch is then resumed.

Abstract: A computing system implements a simulation environment for a graphic design system which creates a plurality of prototype screens that are individually renderable to simulate an application user interface. The computing system displays an initial prototype screen of the plurality of prototype screens, the initial prototype screen including a first set of interactive elements to navigate to a first set of prototype screens, and the computing system loads content associated with each prototype screen of the first set of prototype screens.