Abstract: In some embodiments, a construction management method includes providing, at a central computer, a plurality of interactive 2-D construction drawings, each drawing including a respective affordance of a digital construction entity, where the respective affordances include different 2-D perspectives of the digital construction entity.

Abstract: Particular aspects provide line-walking recursive partitioning (LWRP) methods for evaluating molecular interactions (e.g., enzyme-substrate binding/interaction, protein-protein interaction/docking, protein-small molecule and protein-nucleotide interactions, molecule-molecule and surface-molecule interactions, protein activity inhibition or activation based on a molecular interaction/binding event, or modulation or inhibition of P450 drug metabolism). A training set serves as a collection of molecular points in m-dimensional space, each dimension corresponding to a chemical descriptor, each point having a molecule-descriptor value. In this geometric setting, dissection of the space into regions is decided according to LWRP-generated hyperplanes; a novel ‘line-walking algorithm’ is used to generate optimal hyperplanes for recursive partitioning. Preferably, such line-walking embodiments additionally comprise use of a small or reduced number of descriptors relative to prior art methods.